No association between the PCM1 gene and schizophrenia

A multi-center case-control study and a meta-analysis

Ryota Hashimoto, Kazutaka Ohi, Yuka Yasuda, Motoyuki Fukumoto, Hidenaga Yamamori, Kouzin Kamino, Takashi Morihara, Masao Iwase, Hiroaki Kazui, Shusuke Numata, Masashi Ikeda, Shu ichi Ueno, Tetsuro Ohmori, Nakao Iwata, Norio Ozaki, Masatoshi Takeda

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Alterations in centrosomal function have been suggested in the pathology of schizophrenia. The molecule pericentriolar material 1 (PCM1) is involved in maintaining centrosome integrity and in the regulation of the microtubule cytoskeleton. PCM1 forms a complex at the centrosome with the disrupted-in-schizophrenia 1 (DISC1) protein, which is a major susceptibility factor for schizophrenia. The association between genetic variants in the PCM1 gene and schizophrenia has been reported by several case-control studies, linkage studies and a meta-analysis. The aims of this study are to replicate the association between four single-nucleotide polymorphisms (SNPs) in the PCM1 gene and schizophrenia in a Japanese population (1496 cases and 1845 controls) and to perform a meta-analysis of the combined sample groups (3289 cases and 3567 controls). We failed to find a significant association between SNPs or haplotypes of the PCM1 gene and schizophrenia in the Japanese population (P>. 0.28). The meta-analysis did not reveal an association between the four examined SNPs and schizophrenia. Our data did not support genetic variants in the PCM1 gene as a susceptibility locus for schizophrenia.

Original languageEnglish
Pages (from-to)80-84
Number of pages5
JournalSchizophrenia Research
Volume129
Issue number1
DOIs
Publication statusPublished - 01-06-2011

Fingerprint

Meta-Analysis
Case-Control Studies
Schizophrenia
Genes
Single Nucleotide Polymorphism
Centrosome
Cytoskeleton
Microtubules
Haplotypes
Population
Pathology
Proteins

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Hashimoto, R., Ohi, K., Yasuda, Y., Fukumoto, M., Yamamori, H., Kamino, K., ... Takeda, M. (2011). No association between the PCM1 gene and schizophrenia: A multi-center case-control study and a meta-analysis. Schizophrenia Research, 129(1), 80-84. https://doi.org/10.1016/j.schres.2011.03.024
Hashimoto, Ryota ; Ohi, Kazutaka ; Yasuda, Yuka ; Fukumoto, Motoyuki ; Yamamori, Hidenaga ; Kamino, Kouzin ; Morihara, Takashi ; Iwase, Masao ; Kazui, Hiroaki ; Numata, Shusuke ; Ikeda, Masashi ; Ueno, Shu ichi ; Ohmori, Tetsuro ; Iwata, Nakao ; Ozaki, Norio ; Takeda, Masatoshi. / No association between the PCM1 gene and schizophrenia : A multi-center case-control study and a meta-analysis. In: Schizophrenia Research. 2011 ; Vol. 129, No. 1. pp. 80-84.
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abstract = "Alterations in centrosomal function have been suggested in the pathology of schizophrenia. The molecule pericentriolar material 1 (PCM1) is involved in maintaining centrosome integrity and in the regulation of the microtubule cytoskeleton. PCM1 forms a complex at the centrosome with the disrupted-in-schizophrenia 1 (DISC1) protein, which is a major susceptibility factor for schizophrenia. The association between genetic variants in the PCM1 gene and schizophrenia has been reported by several case-control studies, linkage studies and a meta-analysis. The aims of this study are to replicate the association between four single-nucleotide polymorphisms (SNPs) in the PCM1 gene and schizophrenia in a Japanese population (1496 cases and 1845 controls) and to perform a meta-analysis of the combined sample groups (3289 cases and 3567 controls). We failed to find a significant association between SNPs or haplotypes of the PCM1 gene and schizophrenia in the Japanese population (P>. 0.28). The meta-analysis did not reveal an association between the four examined SNPs and schizophrenia. Our data did not support genetic variants in the PCM1 gene as a susceptibility locus for schizophrenia.",
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Hashimoto, R, Ohi, K, Yasuda, Y, Fukumoto, M, Yamamori, H, Kamino, K, Morihara, T, Iwase, M, Kazui, H, Numata, S, Ikeda, M, Ueno, SI, Ohmori, T, Iwata, N, Ozaki, N & Takeda, M 2011, 'No association between the PCM1 gene and schizophrenia: A multi-center case-control study and a meta-analysis', Schizophrenia Research, vol. 129, no. 1, pp. 80-84. https://doi.org/10.1016/j.schres.2011.03.024

No association between the PCM1 gene and schizophrenia : A multi-center case-control study and a meta-analysis. / Hashimoto, Ryota; Ohi, Kazutaka; Yasuda, Yuka; Fukumoto, Motoyuki; Yamamori, Hidenaga; Kamino, Kouzin; Morihara, Takashi; Iwase, Masao; Kazui, Hiroaki; Numata, Shusuke; Ikeda, Masashi; Ueno, Shu ichi; Ohmori, Tetsuro; Iwata, Nakao; Ozaki, Norio; Takeda, Masatoshi.

In: Schizophrenia Research, Vol. 129, No. 1, 01.06.2011, p. 80-84.

Research output: Contribution to journalArticle

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AU - Ohi, Kazutaka

AU - Yasuda, Yuka

AU - Fukumoto, Motoyuki

AU - Yamamori, Hidenaga

AU - Kamino, Kouzin

AU - Morihara, Takashi

AU - Iwase, Masao

AU - Kazui, Hiroaki

AU - Numata, Shusuke

AU - Ikeda, Masashi

AU - Ueno, Shu ichi

AU - Ohmori, Tetsuro

AU - Iwata, Nakao

AU - Ozaki, Norio

AU - Takeda, Masatoshi

PY - 2011/6/1

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N2 - Alterations in centrosomal function have been suggested in the pathology of schizophrenia. The molecule pericentriolar material 1 (PCM1) is involved in maintaining centrosome integrity and in the regulation of the microtubule cytoskeleton. PCM1 forms a complex at the centrosome with the disrupted-in-schizophrenia 1 (DISC1) protein, which is a major susceptibility factor for schizophrenia. The association between genetic variants in the PCM1 gene and schizophrenia has been reported by several case-control studies, linkage studies and a meta-analysis. The aims of this study are to replicate the association between four single-nucleotide polymorphisms (SNPs) in the PCM1 gene and schizophrenia in a Japanese population (1496 cases and 1845 controls) and to perform a meta-analysis of the combined sample groups (3289 cases and 3567 controls). We failed to find a significant association between SNPs or haplotypes of the PCM1 gene and schizophrenia in the Japanese population (P>. 0.28). The meta-analysis did not reveal an association between the four examined SNPs and schizophrenia. Our data did not support genetic variants in the PCM1 gene as a susceptibility locus for schizophrenia.

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