TY - JOUR
T1 - No association between the PCM1 gene and schizophrenia
T2 - A multi-center case-control study and a meta-analysis
AU - Hashimoto, Ryota
AU - Ohi, Kazutaka
AU - Yasuda, Yuka
AU - Fukumoto, Motoyuki
AU - Yamamori, Hidenaga
AU - Kamino, Kouzin
AU - Morihara, Takashi
AU - Iwase, Masao
AU - Kazui, Hiroaki
AU - Numata, Shusuke
AU - Ikeda, Masashi
AU - Ueno, Shu ichi
AU - Ohmori, Tetsuro
AU - Iwata, Nakao
AU - Ozaki, Norio
AU - Takeda, Masatoshi
N1 - Funding Information:
This work was funded in part by Grants-in-aid from the Japanese Ministry of Health, Labor and Welfare (H18-kokoro-005, H19-kokoro-002, Comprehensive Research on Disability Health and Welfare, and the Research Committee of System Development for Clinical Trials in Psychiatry and Neurology), the Japanese Ministry of Education, Culture, Sports, Science and Technology (18689030), CREST of JST, Grant-in-aid for Scientific Research on Priority Areas—Research on the Pathomechanisms of Brain Disorders—from the MEXT (18023045) and the Japan Foundation for Neuroscience and Mental Health.
PY - 2011/6
Y1 - 2011/6
N2 - Alterations in centrosomal function have been suggested in the pathology of schizophrenia. The molecule pericentriolar material 1 (PCM1) is involved in maintaining centrosome integrity and in the regulation of the microtubule cytoskeleton. PCM1 forms a complex at the centrosome with the disrupted-in-schizophrenia 1 (DISC1) protein, which is a major susceptibility factor for schizophrenia. The association between genetic variants in the PCM1 gene and schizophrenia has been reported by several case-control studies, linkage studies and a meta-analysis. The aims of this study are to replicate the association between four single-nucleotide polymorphisms (SNPs) in the PCM1 gene and schizophrenia in a Japanese population (1496 cases and 1845 controls) and to perform a meta-analysis of the combined sample groups (3289 cases and 3567 controls). We failed to find a significant association between SNPs or haplotypes of the PCM1 gene and schizophrenia in the Japanese population (P>. 0.28). The meta-analysis did not reveal an association between the four examined SNPs and schizophrenia. Our data did not support genetic variants in the PCM1 gene as a susceptibility locus for schizophrenia.
AB - Alterations in centrosomal function have been suggested in the pathology of schizophrenia. The molecule pericentriolar material 1 (PCM1) is involved in maintaining centrosome integrity and in the regulation of the microtubule cytoskeleton. PCM1 forms a complex at the centrosome with the disrupted-in-schizophrenia 1 (DISC1) protein, which is a major susceptibility factor for schizophrenia. The association between genetic variants in the PCM1 gene and schizophrenia has been reported by several case-control studies, linkage studies and a meta-analysis. The aims of this study are to replicate the association between four single-nucleotide polymorphisms (SNPs) in the PCM1 gene and schizophrenia in a Japanese population (1496 cases and 1845 controls) and to perform a meta-analysis of the combined sample groups (3289 cases and 3567 controls). We failed to find a significant association between SNPs or haplotypes of the PCM1 gene and schizophrenia in the Japanese population (P>. 0.28). The meta-analysis did not reveal an association between the four examined SNPs and schizophrenia. Our data did not support genetic variants in the PCM1 gene as a susceptibility locus for schizophrenia.
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U2 - 10.1016/j.schres.2011.03.024
DO - 10.1016/j.schres.2011.03.024
M3 - Article
C2 - 21481569
AN - SCOPUS:79956157001
VL - 129
SP - 80
EP - 84
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1
ER -