Abstract
Alterations in centrosomal function have been suggested in the pathology of schizophrenia. The molecule pericentriolar material 1 (PCM1) is involved in maintaining centrosome integrity and in the regulation of the microtubule cytoskeleton. PCM1 forms a complex at the centrosome with the disrupted-in-schizophrenia 1 (DISC1) protein, which is a major susceptibility factor for schizophrenia. The association between genetic variants in the PCM1 gene and schizophrenia has been reported by several case-control studies, linkage studies and a meta-analysis. The aims of this study are to replicate the association between four single-nucleotide polymorphisms (SNPs) in the PCM1 gene and schizophrenia in a Japanese population (1496 cases and 1845 controls) and to perform a meta-analysis of the combined sample groups (3289 cases and 3567 controls). We failed to find a significant association between SNPs or haplotypes of the PCM1 gene and schizophrenia in the Japanese population (P>. 0.28). The meta-analysis did not reveal an association between the four examined SNPs and schizophrenia. Our data did not support genetic variants in the PCM1 gene as a susceptibility locus for schizophrenia.
| Original language | English |
|---|---|
| Pages (from-to) | 80-84 |
| Number of pages | 5 |
| Journal | Schizophrenia Research |
| Volume | 129 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 01-06-2011 |
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All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
- Biological Psychiatry
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No association between the PCM1 gene and schizophrenia : A multi-center case-control study and a meta-analysis. / Hashimoto, Ryota; Ohi, Kazutaka; Yasuda, Yuka; Fukumoto, Motoyuki; Yamamori, Hidenaga; Kamino, Kouzin; Morihara, Takashi; Iwase, Masao; Kazui, Hiroaki; Numata, Shusuke; Ikeda, Masashi; Ueno, Shu ichi; Ohmori, Tetsuro; Iwata, Nakao; Ozaki, Norio; Takeda, Masatoshi.
In: Schizophrenia Research, Vol. 129, No. 1, 01.06.2011, p. 80-84.Research output: Contribution to journal › Article
TY - JOUR
T1 - No association between the PCM1 gene and schizophrenia
T2 - A multi-center case-control study and a meta-analysis
AU - Hashimoto, Ryota
AU - Ohi, Kazutaka
AU - Yasuda, Yuka
AU - Fukumoto, Motoyuki
AU - Yamamori, Hidenaga
AU - Kamino, Kouzin
AU - Morihara, Takashi
AU - Iwase, Masao
AU - Kazui, Hiroaki
AU - Numata, Shusuke
AU - Ikeda, Masashi
AU - Ueno, Shu ichi
AU - Ohmori, Tetsuro
AU - Iwata, Nakao
AU - Ozaki, Norio
AU - Takeda, Masatoshi
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Alterations in centrosomal function have been suggested in the pathology of schizophrenia. The molecule pericentriolar material 1 (PCM1) is involved in maintaining centrosome integrity and in the regulation of the microtubule cytoskeleton. PCM1 forms a complex at the centrosome with the disrupted-in-schizophrenia 1 (DISC1) protein, which is a major susceptibility factor for schizophrenia. The association between genetic variants in the PCM1 gene and schizophrenia has been reported by several case-control studies, linkage studies and a meta-analysis. The aims of this study are to replicate the association between four single-nucleotide polymorphisms (SNPs) in the PCM1 gene and schizophrenia in a Japanese population (1496 cases and 1845 controls) and to perform a meta-analysis of the combined sample groups (3289 cases and 3567 controls). We failed to find a significant association between SNPs or haplotypes of the PCM1 gene and schizophrenia in the Japanese population (P>. 0.28). The meta-analysis did not reveal an association between the four examined SNPs and schizophrenia. Our data did not support genetic variants in the PCM1 gene as a susceptibility locus for schizophrenia.
AB - Alterations in centrosomal function have been suggested in the pathology of schizophrenia. The molecule pericentriolar material 1 (PCM1) is involved in maintaining centrosome integrity and in the regulation of the microtubule cytoskeleton. PCM1 forms a complex at the centrosome with the disrupted-in-schizophrenia 1 (DISC1) protein, which is a major susceptibility factor for schizophrenia. The association between genetic variants in the PCM1 gene and schizophrenia has been reported by several case-control studies, linkage studies and a meta-analysis. The aims of this study are to replicate the association between four single-nucleotide polymorphisms (SNPs) in the PCM1 gene and schizophrenia in a Japanese population (1496 cases and 1845 controls) and to perform a meta-analysis of the combined sample groups (3289 cases and 3567 controls). We failed to find a significant association between SNPs or haplotypes of the PCM1 gene and schizophrenia in the Japanese population (P>. 0.28). The meta-analysis did not reveal an association between the four examined SNPs and schizophrenia. Our data did not support genetic variants in the PCM1 gene as a susceptibility locus for schizophrenia.
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U2 - 10.1016/j.schres.2011.03.024
DO - 10.1016/j.schres.2011.03.024
M3 - Article
VL - 129
SP - 80
EP - 84
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1
ER -