No association between the PCM1 gene and schizophrenia: A multi-center case-control study and a meta-analysis

Ryota Hashimoto, Kazutaka Ohi, Yuka Yasuda, Motoyuki Fukumoto, Hidenaga Yamamori, Kouzin Kamino, Takashi Morihara, Masao Iwase, Hiroaki Kazui, Shusuke Numata, Masashi Ikeda, Shu ichi Ueno, Tetsuro Ohmori, Nakao Iwata, Norio Ozaki, Masatoshi Takeda

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11 Citations (Scopus)

Abstract

Alterations in centrosomal function have been suggested in the pathology of schizophrenia. The molecule pericentriolar material 1 (PCM1) is involved in maintaining centrosome integrity and in the regulation of the microtubule cytoskeleton. PCM1 forms a complex at the centrosome with the disrupted-in-schizophrenia 1 (DISC1) protein, which is a major susceptibility factor for schizophrenia. The association between genetic variants in the PCM1 gene and schizophrenia has been reported by several case-control studies, linkage studies and a meta-analysis. The aims of this study are to replicate the association between four single-nucleotide polymorphisms (SNPs) in the PCM1 gene and schizophrenia in a Japanese population (1496 cases and 1845 controls) and to perform a meta-analysis of the combined sample groups (3289 cases and 3567 controls). We failed to find a significant association between SNPs or haplotypes of the PCM1 gene and schizophrenia in the Japanese population (P>. 0.28). The meta-analysis did not reveal an association between the four examined SNPs and schizophrenia. Our data did not support genetic variants in the PCM1 gene as a susceptibility locus for schizophrenia.

Original languageEnglish
Pages (from-to)80-84
Number of pages5
JournalSchizophrenia Research
Volume129
Issue number1
DOIs
Publication statusPublished - 06-2011

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Hashimoto, R., Ohi, K., Yasuda, Y., Fukumoto, M., Yamamori, H., Kamino, K., Morihara, T., Iwase, M., Kazui, H., Numata, S., Ikeda, M., Ueno, S. I., Ohmori, T., Iwata, N., Ozaki, N., & Takeda, M. (2011). No association between the PCM1 gene and schizophrenia: A multi-center case-control study and a meta-analysis. Schizophrenia Research, 129(1), 80-84. https://doi.org/10.1016/j.schres.2011.03.024