No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: A multicenter study

Hiroshi Kunugi, Yoshimi Iijima, Masahiko Tatsumi, Mariko Yoshida, Ryota Hashimoto, Tadafumi Kato, Kaoru Sakamoto, Takako Fukunaga, Toshiya Inada, Tatsuyo Suzuki, Nakao Iwata, Norio Ozaki, Kazuo Yamada, Takeo Yoshikawa

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Abstract

Background: Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported, necessitating further investigation. Methods: We organized a multicenter study of a relatively large sample of 519 patients with bipolar disorder (according to DSM-IV criteria) and 588 control subjects matched for gender, age, and ethnicity (Japanese). Genotyping was done by polymerase chain reaction-based restriction fragment length polymorphism or direct sequencing. Results: The genotype distributions and allele frequencies were similar among the patients and control subjects. Even if the possible relationships of the polymorphism with several clinical variables (i.e., bipolar I or II, presence of psychotic features, family history, and age of onset) were examined, no variable was related to the polymorphism. Conclusions: The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.

Original languageEnglish
Pages (from-to)376-378
Number of pages3
JournalBiological Psychiatry
Volume56
Issue number5
DOIs
Publication statusPublished - 01-09-2004

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All Science Journal Classification (ASJC) codes

  • Biological Psychiatry

Cite this

Kunugi, H., Iijima, Y., Tatsumi, M., Yoshida, M., Hashimoto, R., Kato, T., Sakamoto, K., Fukunaga, T., Inada, T., Suzuki, T., Iwata, N., Ozaki, N., Yamada, K., & Yoshikawa, T. (2004). No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: A multicenter study. Biological Psychiatry, 56(5), 376-378. https://doi.org/10.1016/j.biopsych.2004.06.017