Abstract
Background: Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported, necessitating further investigation. Methods: We organized a multicenter study of a relatively large sample of 519 patients with bipolar disorder (according to DSM-IV criteria) and 588 control subjects matched for gender, age, and ethnicity (Japanese). Genotyping was done by polymerase chain reaction-based restriction fragment length polymorphism or direct sequencing. Results: The genotype distributions and allele frequencies were similar among the patients and control subjects. Even if the possible relationships of the polymorphism with several clinical variables (i.e., bipolar I or II, presence of psychotic features, family history, and age of onset) were examined, no variable was related to the polymorphism. Conclusions: The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.
| Original language | English |
|---|---|
| Pages (from-to) | 376-378 |
| Number of pages | 3 |
| Journal | Biological Psychiatry |
| Volume | 56 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 01-09-2004 |
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All Science Journal Classification (ASJC) codes
- Biological Psychiatry
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No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population : A multicenter study. / Kunugi, Hiroshi; Iijima, Yoshimi; Tatsumi, Masahiko; Yoshida, Mariko; Hashimoto, Ryota; Kato, Tadafumi; Sakamoto, Kaoru; Fukunaga, Takako; Inada, Toshiya; Suzuki, Tatsuyo; Iwata, Nakao; Ozaki, Norio; Yamada, Kazuo; Yoshikawa, Takeo.
In: Biological Psychiatry, Vol. 56, No. 5, 01.09.2004, p. 376-378.Research output: Contribution to journal › Article
TY - JOUR
T1 - No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population
T2 - A multicenter study
AU - Kunugi, Hiroshi
AU - Iijima, Yoshimi
AU - Tatsumi, Masahiko
AU - Yoshida, Mariko
AU - Hashimoto, Ryota
AU - Kato, Tadafumi
AU - Sakamoto, Kaoru
AU - Fukunaga, Takako
AU - Inada, Toshiya
AU - Suzuki, Tatsuyo
AU - Iwata, Nakao
AU - Ozaki, Norio
AU - Yamada, Kazuo
AU - Yoshikawa, Takeo
PY - 2004/9/1
Y1 - 2004/9/1
N2 - Background: Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported, necessitating further investigation. Methods: We organized a multicenter study of a relatively large sample of 519 patients with bipolar disorder (according to DSM-IV criteria) and 588 control subjects matched for gender, age, and ethnicity (Japanese). Genotyping was done by polymerase chain reaction-based restriction fragment length polymorphism or direct sequencing. Results: The genotype distributions and allele frequencies were similar among the patients and control subjects. Even if the possible relationships of the polymorphism with several clinical variables (i.e., bipolar I or II, presence of psychotic features, family history, and age of onset) were examined, no variable was related to the polymorphism. Conclusions: The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.
AB - Background: Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported, necessitating further investigation. Methods: We organized a multicenter study of a relatively large sample of 519 patients with bipolar disorder (according to DSM-IV criteria) and 588 control subjects matched for gender, age, and ethnicity (Japanese). Genotyping was done by polymerase chain reaction-based restriction fragment length polymorphism or direct sequencing. Results: The genotype distributions and allele frequencies were similar among the patients and control subjects. Even if the possible relationships of the polymorphism with several clinical variables (i.e., bipolar I or II, presence of psychotic features, family history, and age of onset) were examined, no variable was related to the polymorphism. Conclusions: The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.
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U2 - 10.1016/j.biopsych.2004.06.017
DO - 10.1016/j.biopsych.2004.06.017
M3 - Article
VL - 56
SP - 376
EP - 378
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 5
ER -