No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population

A multicenter study

Hiroshi Kunugi, Yoshimi Iijima, Masahiko Tatsumi, Mariko Yoshida, Ryota Hashimoto, Tadafumi Kato, Kaoru Sakamoto, Takako Fukunaga, Toshiya Inada, Tatsuyo Suzuki, Nakao Iwata, Norio Ozaki, Kazuo Yamada, Takeo Yoshikawa

Research output: Contribution to journalArticle

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Abstract

Background: Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported, necessitating further investigation. Methods: We organized a multicenter study of a relatively large sample of 519 patients with bipolar disorder (according to DSM-IV criteria) and 588 control subjects matched for gender, age, and ethnicity (Japanese). Genotyping was done by polymerase chain reaction-based restriction fragment length polymorphism or direct sequencing. Results: The genotype distributions and allele frequencies were similar among the patients and control subjects. Even if the possible relationships of the polymorphism with several clinical variables (i.e., bipolar I or II, presence of psychotic features, family history, and age of onset) were examined, no variable was related to the polymorphism. Conclusions: The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.

Original languageEnglish
Pages (from-to)376-378
Number of pages3
JournalBiological Psychiatry
Volume56
Issue number5
DOIs
Publication statusPublished - 01-09-2004

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Brain-Derived Neurotrophic Factor
Bipolar Disorder
Multicenter Studies
Population
Genes
Age of Onset
Gene Frequency
Diagnostic and Statistical Manual of Mental Disorders
Restriction Fragment Length Polymorphisms
Genotype
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Biological Psychiatry

Cite this

Kunugi, Hiroshi ; Iijima, Yoshimi ; Tatsumi, Masahiko ; Yoshida, Mariko ; Hashimoto, Ryota ; Kato, Tadafumi ; Sakamoto, Kaoru ; Fukunaga, Takako ; Inada, Toshiya ; Suzuki, Tatsuyo ; Iwata, Nakao ; Ozaki, Norio ; Yamada, Kazuo ; Yoshikawa, Takeo. / No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population : A multicenter study. In: Biological Psychiatry. 2004 ; Vol. 56, No. 5. pp. 376-378.
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abstract = "Background: Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported, necessitating further investigation. Methods: We organized a multicenter study of a relatively large sample of 519 patients with bipolar disorder (according to DSM-IV criteria) and 588 control subjects matched for gender, age, and ethnicity (Japanese). Genotyping was done by polymerase chain reaction-based restriction fragment length polymorphism or direct sequencing. Results: The genotype distributions and allele frequencies were similar among the patients and control subjects. Even if the possible relationships of the polymorphism with several clinical variables (i.e., bipolar I or II, presence of psychotic features, family history, and age of onset) were examined, no variable was related to the polymorphism. Conclusions: The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.",
author = "Hiroshi Kunugi and Yoshimi Iijima and Masahiko Tatsumi and Mariko Yoshida and Ryota Hashimoto and Tadafumi Kato and Kaoru Sakamoto and Takako Fukunaga and Toshiya Inada and Tatsuyo Suzuki and Nakao Iwata and Norio Ozaki and Kazuo Yamada and Takeo Yoshikawa",
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Kunugi, H, Iijima, Y, Tatsumi, M, Yoshida, M, Hashimoto, R, Kato, T, Sakamoto, K, Fukunaga, T, Inada, T, Suzuki, T, Iwata, N, Ozaki, N, Yamada, K & Yoshikawa, T 2004, 'No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: A multicenter study', Biological Psychiatry, vol. 56, no. 5, pp. 376-378. https://doi.org/10.1016/j.biopsych.2004.06.017

No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population : A multicenter study. / Kunugi, Hiroshi; Iijima, Yoshimi; Tatsumi, Masahiko; Yoshida, Mariko; Hashimoto, Ryota; Kato, Tadafumi; Sakamoto, Kaoru; Fukunaga, Takako; Inada, Toshiya; Suzuki, Tatsuyo; Iwata, Nakao; Ozaki, Norio; Yamada, Kazuo; Yoshikawa, Takeo.

In: Biological Psychiatry, Vol. 56, No. 5, 01.09.2004, p. 376-378.

Research output: Contribution to journalArticle

TY - JOUR

T1 - No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population

T2 - A multicenter study

AU - Kunugi, Hiroshi

AU - Iijima, Yoshimi

AU - Tatsumi, Masahiko

AU - Yoshida, Mariko

AU - Hashimoto, Ryota

AU - Kato, Tadafumi

AU - Sakamoto, Kaoru

AU - Fukunaga, Takako

AU - Inada, Toshiya

AU - Suzuki, Tatsuyo

AU - Iwata, Nakao

AU - Ozaki, Norio

AU - Yamada, Kazuo

AU - Yoshikawa, Takeo

PY - 2004/9/1

Y1 - 2004/9/1

N2 - Background: Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported, necessitating further investigation. Methods: We organized a multicenter study of a relatively large sample of 519 patients with bipolar disorder (according to DSM-IV criteria) and 588 control subjects matched for gender, age, and ethnicity (Japanese). Genotyping was done by polymerase chain reaction-based restriction fragment length polymorphism or direct sequencing. Results: The genotype distributions and allele frequencies were similar among the patients and control subjects. Even if the possible relationships of the polymorphism with several clinical variables (i.e., bipolar I or II, presence of psychotic features, family history, and age of onset) were examined, no variable was related to the polymorphism. Conclusions: The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.

AB - Background: Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported, necessitating further investigation. Methods: We organized a multicenter study of a relatively large sample of 519 patients with bipolar disorder (according to DSM-IV criteria) and 588 control subjects matched for gender, age, and ethnicity (Japanese). Genotyping was done by polymerase chain reaction-based restriction fragment length polymorphism or direct sequencing. Results: The genotype distributions and allele frequencies were similar among the patients and control subjects. Even if the possible relationships of the polymorphism with several clinical variables (i.e., bipolar I or II, presence of psychotic features, family history, and age of onset) were examined, no variable was related to the polymorphism. Conclusions: The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.

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