No association is found between the candidate genes of t-PA/plasminogen system and Japanese methamphetamine-related disorder: A collaborative study by the Japanese genetics initiative for drug abuse

Nakao Iwata, T. Inada, M. Harano, T. Komiyama, M. Yamada, Y. Sekine, M. Iyo, I. Sora, H. Ujike, N. Ozaki

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In the central nervous system, tissue-plasminogen activator (t-PA)/ plasmin system is involved in long-term synaptic plasticity and remodeling, and participates in rewarding effects of methamphetamine (MAP), by acutely regulating MAP-induced dopamine release in the nucleus accumbens. The aim of this study was to examine the relationships between the patients with MAP abusers/psychosis and the t-PA/plasminogen system genes. Subjects comprised 185 MAP abusers and 288 healthy controls. Four polymorphisms in the t-PA, plasminogen activator inhibitor, and plasminogen genes were examined in the present study. No significant differences were observed in each polymorphism between healthy controls and MAP abusers/psychosis. This study suggests that t-PA/plasminogen system is unlikely to be a major contributor to the substance abuse liability and/or the development of MAP psychosis.

Original languageEnglish
Pages (from-to)34-38
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume1025
DOIs
Publication statusPublished - 01-01-2004

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Methamphetamine
Plasminogen
Tissue Plasminogen Activator
Substance-Related Disorders
Genes
Pharmaceutical Preparations
Psychotic Disorders
Polymorphism
Plasminogen Inactivators
Neuronal Plasticity
Fibrinolysin
Nucleus Accumbens
Neurology
Plasticity
Genetics
Gene
Abuse
Psychosis
Drugs
Dopamine

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

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abstract = "In the central nervous system, tissue-plasminogen activator (t-PA)/ plasmin system is involved in long-term synaptic plasticity and remodeling, and participates in rewarding effects of methamphetamine (MAP), by acutely regulating MAP-induced dopamine release in the nucleus accumbens. The aim of this study was to examine the relationships between the patients with MAP abusers/psychosis and the t-PA/plasminogen system genes. Subjects comprised 185 MAP abusers and 288 healthy controls. Four polymorphisms in the t-PA, plasminogen activator inhibitor, and plasminogen genes were examined in the present study. No significant differences were observed in each polymorphism between healthy controls and MAP abusers/psychosis. This study suggests that t-PA/plasminogen system is unlikely to be a major contributor to the substance abuse liability and/or the development of MAP psychosis.",
author = "Nakao Iwata and T. Inada and M. Harano and T. Komiyama and M. Yamada and Y. Sekine and M. Iyo and I. Sora and H. Ujike and N. Ozaki",
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No association is found between the candidate genes of t-PA/plasminogen system and Japanese methamphetamine-related disorder : A collaborative study by the Japanese genetics initiative for drug abuse. / Iwata, Nakao; Inada, T.; Harano, M.; Komiyama, T.; Yamada, M.; Sekine, Y.; Iyo, M.; Sora, I.; Ujike, H.; Ozaki, N.

In: Annals of the New York Academy of Sciences, Vol. 1025, 01.01.2004, p. 34-38.

Research output: Contribution to journalArticle

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AU - Iwata, Nakao

AU - Inada, T.

AU - Harano, M.

AU - Komiyama, T.

AU - Yamada, M.

AU - Sekine, Y.

AU - Iyo, M.

AU - Sora, I.

AU - Ujike, H.

AU - Ozaki, N.

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