No association is found between the candidate genes of t-PA/plasminogen system and Japanese methamphetamine-related disorder: A collaborative study by the Japanese genetics initiative for drug abuse

N. Iwata, T. Inada, M. Harano, T. Komiyama, M. Yamada, Y. Sekine, M. Iyo, I. Sora, H. Ujike, N. Ozaki

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In the central nervous system, tissue-plasminogen activator (t-PA)/ plasmin system is involved in long-term synaptic plasticity and remodeling, and participates in rewarding effects of methamphetamine (MAP), by acutely regulating MAP-induced dopamine release in the nucleus accumbens. The aim of this study was to examine the relationships between the patients with MAP abusers/psychosis and the t-PA/plasminogen system genes. Subjects comprised 185 MAP abusers and 288 healthy controls. Four polymorphisms in the t-PA, plasminogen activator inhibitor, and plasminogen genes were examined in the present study. No significant differences were observed in each polymorphism between healthy controls and MAP abusers/psychosis. This study suggests that t-PA/plasminogen system is unlikely to be a major contributor to the substance abuse liability and/or the development of MAP psychosis.

Original languageEnglish
Pages (from-to)34-38
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume1025
DOIs
Publication statusPublished - 2004

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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