No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population

Taro Kishi, Masashi Ikeda, Tatsuyo Suzuki, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Norio Ozaki, Nakao Iwata

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9 Citations (Scopus)

Abstract

Several investigations suggest that complexin may be a schizophrenia- susceptibility factor. We conducted a genetic association analysis between complexin genes (CPLX1 and CPLX2) and schizophrenia in Japanese patients (377 cases and 341 controls). Ten and eleven haplotype-tagging (ht)SNPs in CPLX1 and CPLX2, respectively, were selected. Only one htSNP (rs930047 in CPLX2) in allele-wise analysis showed significance, and even this disappeared with an increased sample size (563 cases and 519 controls: P = .757). Haplotype-wise analysis showed a weak association with a combination of htSNPs in CPLX2 (P = .0424), but this may be a result of type I error due to multiple testing. Our results suggest that complexin genes do not play a major role in schizophrenia in Japanese patients.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalSchizophrenia Research
Volume82
Issue number2-3
DOIs
Publication statusPublished - 28-02-2006

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All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

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