No association of GSK3β gene (GSK3B) with Japanese schizophrenia

Masashi Ikeda, Nakao Iwata, Tatsuyo Suzuki, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Norio Ozaki

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Several lines of evidence indicate that glycogen synthase kinase-3β (GSK3β) is one of the candidates for schizophrenia-susceptibility factor. However, it has not been reported the association analysis between GSK3β gene (GSK3B) and Japanese schizophrenia based on linkage disequilibrium (LD). We provide an association analysis using relatively large samples (381 schizophrenia, and 352 controls) after determination of "tag single nucleotide polymorphisms (SNPs)." In this LD mapping, we selected and genotyped for eight polymorphisms (seven SNPs and one diallelic (CAA) n repeat), which covered the entire region of GSK3B, and determined two "tag SNPs." In the following association analysis using these two "tag SNPs," we could not find association with Japanese schizophrenia. Furthermore, we also include subgroup analysis considering age-at-onset and subtypes, neither could we find associations. Because our samples provided quite high power, these results indicate that GSK3B may not play a major role in Japanese schizophrenia.

Original languageEnglish
Pages (from-to)90-92
Number of pages3
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume134 B
Issue number1
DOIs
Publication statusPublished - 05-04-2005

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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