No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients

Masashi Ikeda; Nakao Iwata; Tatsuyo Suzuki; Tsuyoshi Kitajima; Yoshio Yamanouchi; Yoko Kinoshita; Toshiya Inada; Norio Ozaki

doi:10.1016/j.schres.2005.05.002

No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients

Masashi Ikeda, Nakao Iwata, Tatsuyo Suzuki, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Toshiya Inada, Norio Ozaki

Psychiatry

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases = 405, controls = 401) and second-set analysis (cases = 503, controls = 440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis.

Original language	English
Pages (from-to)	127-130
Number of pages	4
Journal	Schizophrenia Research
Volume	78
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2005.05.002
Publication status	Published - 15-10-2005

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2005.05.002

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title = "No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients",

abstract = "Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases = 405, controls = 401) and second-set analysis (cases = 503, controls = 440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis.",

author = "Masashi Ikeda and Nakao Iwata and Tatsuyo Suzuki and Tsuyoshi Kitajima and Yoshio Yamanouchi and Yoko Kinoshita and Toshiya Inada and Norio Ozaki",

note = "Funding Information: This work was supported in part by research grants from the Ministry of Education, Culture, Sports, Science and Technology, and the Ministry of Health, Labor and Welfare, and The Japan Health Sciences Foundation (Research on Health Sciences focusing on Drug Innovation).",

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doi = "10.1016/j.schres.2005.05.002",

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T1 - No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients

AU - Ikeda, Masashi

AU - Iwata, Nakao

AU - Suzuki, Tatsuyo

AU - Kitajima, Tsuyoshi

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Inada, Toshiya

AU - Ozaki, Norio

N1 - Funding Information: This work was supported in part by research grants from the Ministry of Education, Culture, Sports, Science and Technology, and the Ministry of Health, Labor and Welfare, and The Japan Health Sciences Foundation (Research on Health Sciences focusing on Drug Innovation).

PY - 2005/10/15

Y1 - 2005/10/15

N2 - Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases = 405, controls = 401) and second-set analysis (cases = 503, controls = 440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis.

AB - Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases = 405, controls = 401) and second-set analysis (cases = 503, controls = 440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis.

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No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients

Abstract

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UN SDGs

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