TY - JOUR
T1 - No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients
AU - Ikeda, Masashi
AU - Iwata, Nakao
AU - Suzuki, Tatsuyo
AU - Kitajima, Tsuyoshi
AU - Yamanouchi, Yoshio
AU - Kinoshita, Yoko
AU - Inada, Toshiya
AU - Ozaki, Norio
N1 - Funding Information:
This work was supported in part by research grants from the Ministry of Education, Culture, Sports, Science and Technology, and the Ministry of Health, Labor and Welfare, and The Japan Health Sciences Foundation (Research on Health Sciences focusing on Drug Innovation).
PY - 2005/10/15
Y1 - 2005/10/15
N2 - Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases = 405, controls = 401) and second-set analysis (cases = 503, controls = 440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis.
AB - Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases = 405, controls = 401) and second-set analysis (cases = 503, controls = 440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis.
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U2 - 10.1016/j.schres.2005.05.002
DO - 10.1016/j.schres.2005.05.002
M3 - Article
C2 - 15970431
AN - SCOPUS:24344445875
VL - 78
SP - 127
EP - 130
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 2-3
ER -