TY - JOUR
T1 - No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients
AU - Ikeda, Masashi
AU - Iwata, Nakao
AU - Suzuki, Tatsuyo
AU - Kitajima, Tsuyoshi
AU - Yamanouchi, Yoshio
AU - Kinoshita, Yoko
AU - Inada, Toshiya
AU - Ozaki, Norio
PY - 2005/10/15
Y1 - 2005/10/15
N2 - Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases = 405, controls = 401) and second-set analysis (cases = 503, controls = 440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis.
AB - Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases = 405, controls = 401) and second-set analysis (cases = 503, controls = 440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis.
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U2 - 10.1016/j.schres.2005.05.002
DO - 10.1016/j.schres.2005.05.002
M3 - Article
C2 - 15970431
AN - SCOPUS:24344445875
VL - 78
SP - 127
EP - 130
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 2-3
ER -