Abstract
Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases = 405, controls = 401) and second-set analysis (cases = 503, controls = 440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis.
| Original language | English |
|---|---|
| Pages (from-to) | 127-130 |
| Number of pages | 4 |
| Journal | Schizophrenia Research |
| Volume | 78 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 15-10-2005 |
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All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
- Biological Psychiatry
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No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients. / Ikeda, Masashi; Iwata, Nakao; Suzuki, Tatsuyo; Kitajima, Tsuyoshi; Yamanouchi, Yoshio; Kinoshita, Yoko; Inada, Toshiya; Ozaki, Norio.
In: Schizophrenia Research, Vol. 78, No. 2-3, 15.10.2005, p. 127-130.Research output: Contribution to journal › Article
TY - JOUR
T1 - No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients
AU - Ikeda, Masashi
AU - Iwata, Nakao
AU - Suzuki, Tatsuyo
AU - Kitajima, Tsuyoshi
AU - Yamanouchi, Yoshio
AU - Kinoshita, Yoko
AU - Inada, Toshiya
AU - Ozaki, Norio
PY - 2005/10/15
Y1 - 2005/10/15
N2 - Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases = 405, controls = 401) and second-set analysis (cases = 503, controls = 440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis.
AB - Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases = 405, controls = 401) and second-set analysis (cases = 503, controls = 440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis.
UR - http://www.scopus.com/inward/record.url?scp=24344445875&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=24344445875&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2005.05.002
DO - 10.1016/j.schres.2005.05.002
M3 - Article
C2 - 15970431
AN - SCOPUS:24344445875
VL - 78
SP - 127
EP - 130
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 2-3
ER -