No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients

Masashi Ikeda; Nakao Iwata; Tatsuyo Suzuki; Tsuyoshi Kitajima; Yoshio Yamanouchi; Yoko Kinoshita; Toshiya Inada; Norio Ozaki

doi:10.1016/j.schres.2005.05.002

No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients

Masashi Ikeda, Nakao Iwata, Tatsuyo Suzuki, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Toshiya Inada, Norio Ozaki

Psychiatry

Research output: Contribution to journal › Article

28 Citations (Scopus)

Abstract

Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases = 405, controls = 401) and second-set analysis (cases = 503, controls = 440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis.

Original language	English
Pages (from-to)	127-130
Number of pages	4
Journal	Schizophrenia Research
Volume	78
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2005.05.002
Publication status	Published - 15-10-2005

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
Biological Psychiatry

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Ikeda, M., Iwata, N., Suzuki, T., Kitajima, T., Yamanouchi, Y., Kinoshita, Y., Inada, T., & Ozaki, N. (2005). No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients. Schizophrenia Research, 78(2-3), 127-130. https://doi.org/10.1016/j.schres.2005.05.002

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abstract = "Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases = 405, controls = 401) and second-set analysis (cases = 503, controls = 440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis.",

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AU - Ikeda, Masashi

AU - Iwata, Nakao

AU - Suzuki, Tatsuyo

AU - Kitajima, Tsuyoshi

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Inada, Toshiya

AU - Ozaki, Norio

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