TY - JOUR
T1 - No association was found between a functional SNP in ZDHHC8 and schizophrenia in a Japanese case-control population
AU - Saito, Shinichi
AU - Ikeda, Masashi
AU - Iwata, Nakao
AU - Suzuki, Tatsuyo
AU - Kitajima, Tsuyoshi
AU - Yamanouchi, Yoshio
AU - Kinoshita, Yoko
AU - Takahashi, Nagahide
AU - Inada, Toshiya
AU - Ozaki, Norio
N1 - Funding Information:
We thank the patients and healthy volunteers who took part in our investigation. We also thank Ms. M. Miyata, Ms. Y. Zusho, Ms. S. Nakaguchi and Ms. R. Ishihara for their technical support. This work was supported in part by research grants from the Ministry of Education, Culture, Sports, Science and Technology and that of Health, Labor and Welfare.
PY - 2005/2/1
Y1 - 2005/2/1
N2 - ZDHHC8 is a new and attractive candidate for a schizophrenia-susceptibility factor. First, several lines of linkage studies showed that 22q11, on which ZDHHC8 is located, is a "hot" region. Second, fine linkage disequilibrium mapping revealed a significant association around ZDHHC8. Moreover, a very recent study reported that one single nucleotide polymorphism (SNP: rs175174) in ZDHHC8 might affect the splicing process, the ZDHHC8 knock-out mice showed the gender-specific phenotype, and the transmission disequilibrium test (TDT) using this SNP also showed significant association with human female schizophrenia. Thus, we attempted a replication study of this SNP using relatively large Japanese case-control samples (561 schizophrenics and 529 controls). No association was found between schizophrenia and controls even after dividing samples by gender. Because our sample size provided quite high power, ZDHHC8 may not play a major role in Japanese schizophrenia. And our results did not support the gender-specific effect of this SNP.
AB - ZDHHC8 is a new and attractive candidate for a schizophrenia-susceptibility factor. First, several lines of linkage studies showed that 22q11, on which ZDHHC8 is located, is a "hot" region. Second, fine linkage disequilibrium mapping revealed a significant association around ZDHHC8. Moreover, a very recent study reported that one single nucleotide polymorphism (SNP: rs175174) in ZDHHC8 might affect the splicing process, the ZDHHC8 knock-out mice showed the gender-specific phenotype, and the transmission disequilibrium test (TDT) using this SNP also showed significant association with human female schizophrenia. Thus, we attempted a replication study of this SNP using relatively large Japanese case-control samples (561 schizophrenics and 529 controls). No association was found between schizophrenia and controls even after dividing samples by gender. Because our sample size provided quite high power, ZDHHC8 may not play a major role in Japanese schizophrenia. And our results did not support the gender-specific effect of this SNP.
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U2 - 10.1016/j.neulet.2004.10.015
DO - 10.1016/j.neulet.2004.10.015
M3 - Article
C2 - 15631889
AN - SCOPUS:20044376098
SN - 0304-3940
VL - 374
SP - 21
EP - 24
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -