TY - JOUR
T1 - No association with the calcineurin a gamma subunit gene (PPP3CC) haplotype to Japanese schizophrenia
AU - Kinoshita, Y.
AU - Suzuki, T.
AU - Ikeda, M.
AU - Kitajima, T.
AU - Yamanouchi, Y.
AU - Inada, T.
AU - Yoneda, H.
AU - Iwata, N.
AU - Ozaki, N.
PY - 2005/9
Y1 - 2005/9
N2 - Calcineurin, one of the serine/threonine protein phosphatase, comprises more than 1% of the total protein content in brain. This evidence points towards important roles of calcineurin in neural function. Miyakawa et al. reported that forebrain-specific calcineurin knockout mice showed the behavioral abnormalities that are often observed in schizophrenia patients. Based on this evidence, they suggested that calcineurin dysfunction could be involved in schizophrenia pathogenesis. Thereafter this report, Gerber et al. performed transmission disequilibrium test (TDT) studies and showed an evidence for a nominally significant over-transmission of a common haplotype of the human calcineurin A γ subunit gene (PPP3CC). We performed association analysis of PPP3CC in Japanese sample of 457 schizophrenia cases and 429 controls. To our regret, we could not confirm the association with Japanese schizophrenia to PPP3CC including core at-risk haplotype. Our result suggests that PPP3CC may not play a major role in Japanese schizophrenia.
AB - Calcineurin, one of the serine/threonine protein phosphatase, comprises more than 1% of the total protein content in brain. This evidence points towards important roles of calcineurin in neural function. Miyakawa et al. reported that forebrain-specific calcineurin knockout mice showed the behavioral abnormalities that are often observed in schizophrenia patients. Based on this evidence, they suggested that calcineurin dysfunction could be involved in schizophrenia pathogenesis. Thereafter this report, Gerber et al. performed transmission disequilibrium test (TDT) studies and showed an evidence for a nominally significant over-transmission of a common haplotype of the human calcineurin A γ subunit gene (PPP3CC). We performed association analysis of PPP3CC in Japanese sample of 457 schizophrenia cases and 429 controls. To our regret, we could not confirm the association with Japanese schizophrenia to PPP3CC including core at-risk haplotype. Our result suggests that PPP3CC may not play a major role in Japanese schizophrenia.
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U2 - 10.1007/s00702-004-0261-5
DO - 10.1007/s00702-004-0261-5
M3 - Article
C2 - 15843870
AN - SCOPUS:24044504081
SN - 0300-9564
VL - 112
SP - 1255
EP - 1262
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
IS - 9
ER -
