No association with the neuregulin 1 haplotype to Japanese schizophrenia

N. Iwata; T. Suzuki; Masashi Ikeda; T. Kitajima; Y. Yamanouchi; T. Inada; N. Ozaki

doi:10.1038/sj.mp.4001456

No association with the neuregulin 1 haplotype to Japanese schizophrenia

N. Iwata
, T. Suzuki
, Masashi Ikeda
, T. Kitajima
, Y. Yamanouchi
, T. Inada
, N. Ozaki

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

Previous studies show that genetic haplotype within the neuregulin 1 gene (NRG1) increase the risk of developing schizophrenia. The authors described a negative replication that a haplotype of NRG1 did not associate with schizophrenia. Of 607 Japanese schizophrenic patients and 515 controls, the estimated frequency of the core at-risk haplotype had no difference between patients (4.5%) and controls (4.3%). The data suggests that NRG1 haplotype is unlikely to be associated with increased risk of schrizophrenia.

Original language	English
Pages (from-to)	126-127+118
Journal	Molecular Psychiatry
Volume	9
Issue number	2
DOIs	https://doi.org/10.1038/sj.mp.4001456
Publication status	Published - 2004

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Molecular Biology
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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10.1038/sj.mp.4001456

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AU - Inada, T.

AU - Ozaki, N.

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AB - Previous studies show that genetic haplotype within the neuregulin 1 gene (NRG1) increase the risk of developing schizophrenia. The authors described a negative replication that a haplotype of NRG1 did not associate with schizophrenia. Of 607 Japanese schizophrenic patients and 515 controls, the estimated frequency of the core at-risk haplotype had no difference between patients (4.5%) and controls (4.3%). The data suggests that NRG1 haplotype is unlikely to be associated with increased risk of schrizophrenia.

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No association with the neuregulin 1 haplotype to Japanese schizophrenia

Abstract

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All Science Journal Classification (ASJC) codes

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