No changes in cerebrospinal fluid levels of nitrite, nitrate and cyclic GMP with aging

K. Yamada; K. Nishiwaki; K. Hattori; K. Senzaki; M. Nagata; T. Komatsu; Y. Shimada; T. Nabeshima

doi:10.1007/BF01285551

No changes in cerebrospinal fluid levels of nitrite, nitrate and cyclic GMP with aging

K. Yamada, K. Nishiwaki, K. Hattori, K. Senzaki, M. Nagata, T. Komatsu, Y. Shimada, T. Nabeshima

Research Division of Advanced Diagnostic System

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Nitric oxide (NO) is a free radical gas that plays a role in various signal transduction processes. NO has been proposed to have a function in the mechanism of synaptic plasticity, including long-term potentiation and memory formation in vivo. Because a failure in synaptic plasticity is considered to be involved in aging-associated brain dysfunction, NO production in the brain may be altered by aging. In the present study, we measured the levels of NO metabolites, nitrite and nitrate, and cyclic GMP in the cerebrospinal fluid (CSF) of human subjects without neurological or psychiatric disorders. There were no age-related changes in the CSF levels of either nitrite, nitrate or cyclic GMP. These results suggest that NO production in the brain may be maintained during the aging process.

Original language	English
Pages (from-to)	825-831
Number of pages	7
Journal	Journal of Neural Transmission
Volume	104
Issue number	8-9
DOIs	https://doi.org/10.1007/BF01285551
Publication status	Published - 1997

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

Access to Document

10.1007/BF01285551

Fingerprint Dive into the research topics of 'No changes in cerebrospinal fluid levels of nitrite, nitrate and cyclic GMP with aging'. Together they form a unique fingerprint.

Cite this

@article{988bc43e7fdb449091c23fa09ed3ab4d,

title = "No changes in cerebrospinal fluid levels of nitrite, nitrate and cyclic GMP with aging",

abstract = "Nitric oxide (NO) is a free radical gas that plays a role in various signal transduction processes. NO has been proposed to have a function in the mechanism of synaptic plasticity, including long-term potentiation and memory formation in vivo. Because a failure in synaptic plasticity is considered to be involved in aging-associated brain dysfunction, NO production in the brain may be altered by aging. In the present study, we measured the levels of NO metabolites, nitrite and nitrate, and cyclic GMP in the cerebrospinal fluid (CSF) of human subjects without neurological or psychiatric disorders. There were no age-related changes in the CSF levels of either nitrite, nitrate or cyclic GMP. These results suggest that NO production in the brain may be maintained during the aging process.",

author = "K. Yamada and K. Nishiwaki and K. Hattori and K. Senzaki and M. Nagata and T. Komatsu and Y. Shimada and T. Nabeshima",

year = "1997",

doi = "10.1007/BF01285551",

language = "English",

volume = "104",

pages = "825--831",

journal = "Acta Neurovegetativa",

issn = "0375-9245",

publisher = "Springer Verlag",

number = "8-9",

}

TY - JOUR

T1 - No changes in cerebrospinal fluid levels of nitrite, nitrate and cyclic GMP with aging

AU - Yamada, K.

AU - Nishiwaki, K.

AU - Hattori, K.

AU - Senzaki, K.

AU - Nagata, M.

AU - Komatsu, T.

AU - Shimada, Y.

AU - Nabeshima, T.

PY - 1997

Y1 - 1997

N2 - Nitric oxide (NO) is a free radical gas that plays a role in various signal transduction processes. NO has been proposed to have a function in the mechanism of synaptic plasticity, including long-term potentiation and memory formation in vivo. Because a failure in synaptic plasticity is considered to be involved in aging-associated brain dysfunction, NO production in the brain may be altered by aging. In the present study, we measured the levels of NO metabolites, nitrite and nitrate, and cyclic GMP in the cerebrospinal fluid (CSF) of human subjects without neurological or psychiatric disorders. There were no age-related changes in the CSF levels of either nitrite, nitrate or cyclic GMP. These results suggest that NO production in the brain may be maintained during the aging process.

AB - Nitric oxide (NO) is a free radical gas that plays a role in various signal transduction processes. NO has been proposed to have a function in the mechanism of synaptic plasticity, including long-term potentiation and memory formation in vivo. Because a failure in synaptic plasticity is considered to be involved in aging-associated brain dysfunction, NO production in the brain may be altered by aging. In the present study, we measured the levels of NO metabolites, nitrite and nitrate, and cyclic GMP in the cerebrospinal fluid (CSF) of human subjects without neurological or psychiatric disorders. There were no age-related changes in the CSF levels of either nitrite, nitrate or cyclic GMP. These results suggest that NO production in the brain may be maintained during the aging process.

UR - http://www.scopus.com/inward/record.url?scp=0030723891&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030723891&partnerID=8YFLogxK

U2 - 10.1007/BF01285551

DO - 10.1007/BF01285551

M3 - Article

C2 - 9451715

AN - SCOPUS:0030723891

VL - 104

SP - 825

EP - 831

JO - Acta Neurovegetativa

JF - Acta Neurovegetativa

SN - 0375-9245

IS - 8-9

ER -