Abstract
Nitric oxide (NO) is a free radical gas that plays a role in various signal transduction processes. NO has been proposed to have a function in the mechanism of synaptic plasticity, including long-term potentiation and memory formation in vivo. Because a failure in synaptic plasticity is considered to be involved in aging-associated brain dysfunction, NO production in the brain may be altered by aging. In the present study, we measured the levels of NO metabolites, nitrite and nitrate, and cyclic GMP in the cerebrospinal fluid (CSF) of human subjects without neurological or psychiatric disorders. There were no age-related changes in the CSF levels of either nitrite, nitrate or cyclic GMP. These results suggest that NO production in the brain may be maintained during the aging process.
| Original language | English |
|---|---|
| Pages (from-to) | 825-831 |
| Number of pages | 7 |
| Journal | Journal of Neural Transmission |
| Volume | 104 |
| Issue number | 8-9 |
| DOIs | |
| Publication status | Published - 01-01-1997 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
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No changes in cerebrospinal fluid levels of nitrite, nitrate and cyclic GMP with aging. / Yamada, K.; Nishiwaki, K.; Hattori, K.; Senzaki, K.; Nagata, M.; Komatsu, T.; Shimada, Y.; Nabeshima, Toshitaka.
In: Journal of Neural Transmission, Vol. 104, No. 8-9, 01.01.1997, p. 825-831.Research output: Contribution to journal › Article
TY - JOUR
T1 - No changes in cerebrospinal fluid levels of nitrite, nitrate and cyclic GMP with aging
AU - Yamada, K.
AU - Nishiwaki, K.
AU - Hattori, K.
AU - Senzaki, K.
AU - Nagata, M.
AU - Komatsu, T.
AU - Shimada, Y.
AU - Nabeshima, Toshitaka
PY - 1997/1/1
Y1 - 1997/1/1
N2 - Nitric oxide (NO) is a free radical gas that plays a role in various signal transduction processes. NO has been proposed to have a function in the mechanism of synaptic plasticity, including long-term potentiation and memory formation in vivo. Because a failure in synaptic plasticity is considered to be involved in aging-associated brain dysfunction, NO production in the brain may be altered by aging. In the present study, we measured the levels of NO metabolites, nitrite and nitrate, and cyclic GMP in the cerebrospinal fluid (CSF) of human subjects without neurological or psychiatric disorders. There were no age-related changes in the CSF levels of either nitrite, nitrate or cyclic GMP. These results suggest that NO production in the brain may be maintained during the aging process.
AB - Nitric oxide (NO) is a free radical gas that plays a role in various signal transduction processes. NO has been proposed to have a function in the mechanism of synaptic plasticity, including long-term potentiation and memory formation in vivo. Because a failure in synaptic plasticity is considered to be involved in aging-associated brain dysfunction, NO production in the brain may be altered by aging. In the present study, we measured the levels of NO metabolites, nitrite and nitrate, and cyclic GMP in the cerebrospinal fluid (CSF) of human subjects without neurological or psychiatric disorders. There were no age-related changes in the CSF levels of either nitrite, nitrate or cyclic GMP. These results suggest that NO production in the brain may be maintained during the aging process.
UR - http://www.scopus.com/inward/record.url?scp=0030723891&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030723891&partnerID=8YFLogxK
U2 - 10.1007/BF01285551
DO - 10.1007/BF01285551
M3 - Article
C2 - 9451715
AN - SCOPUS:0030723891
VL - 104
SP - 825
EP - 831
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
SN - 0300-9564
IS - 8-9
ER -