No changes in cerebrospinal fluid levels of nitrite, nitrate and cyclic GMP with aging

K. Yamada, K. Nishiwaki, K. Hattori, K. Senzaki, M. Nagata, T. Komatsu, Y. Shimada, T. Nabeshima

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Abstract

Nitric oxide (NO) is a free radical gas that plays a role in various signal transduction processes. NO has been proposed to have a function in the mechanism of synaptic plasticity, including long-term potentiation and memory formation in vivo. Because a failure in synaptic plasticity is considered to be involved in aging-associated brain dysfunction, NO production in the brain may be altered by aging. In the present study, we measured the levels of NO metabolites, nitrite and nitrate, and cyclic GMP in the cerebrospinal fluid (CSF) of human subjects without neurological or psychiatric disorders. There were no age-related changes in the CSF levels of either nitrite, nitrate or cyclic GMP. These results suggest that NO production in the brain may be maintained during the aging process.

Original languageEnglish
Pages (from-to)825-831
Number of pages7
JournalJournal of Neural Transmission
Volume104
Issue number8-9
DOIs
Publication statusPublished - 01-01-1997

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Yamada, K., Nishiwaki, K., Hattori, K., Senzaki, K., Nagata, M., Komatsu, T., Shimada, Y., & Nabeshima, T. (1997). No changes in cerebrospinal fluid levels of nitrite, nitrate and cyclic GMP with aging. Journal of Neural Transmission, 104(8-9), 825-831. https://doi.org/10.1007/BF01285551