No effect of the Trp64Arg variant of the β3-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adults

Shinichi Kuriyama, Taichi Shimazu, Atsushi Hozawa, Shigeo Kure, Naoyuki Kurokawa, Masako Kakizaki, Toshimasa Sone, Kaori Matsuda-Ohmori, Naoki Nakaya, Hiroshi Satoh, Ichiro Tsuji

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Controversy remains as to whether the presence of the tryptophan-to-arginine (Trp64Arg) variant of the β3-adrenergic receptor gene impedes the magnitude of body weight loss by diet and exercise intervention. The objectives of the present study were to compare the changes in body weight between carriers and noncarriers of the Trp64Arg variant before and after 6 months of diet and exercise interventions for weight loss. A total of 37 middle-aged Japanese individuals (12 carriers and 25 noncarriers of the Trp64Arg variant) participated in the study. There were no significant differences in body weight between the 2 groups at the baseline. There were significant reductions in body weight both in carriers and noncarriers, but no significant differences between the 2 groups with respect to changes in these variables. The weight changes were -2.52 kg (95% confidence interval [CI], -3.56 to -1.48) among carriers and -1.89 kg (95% CI, -2.65 to -1.13) among noncarriers, and the change in the variant carrier group minus the change in the variant noncarrier group was -0.47 (95% CI, -1.97 to 1.02). These results suggest that the presence of the Trp64Arg variant of the β3-adrenergic receptor gene may not play a major role as a hindrance to weight reduction.

Original languageEnglish
Pages (from-to)1570-1575
Number of pages6
JournalMetabolism: Clinical and Experimental
Volume57
Issue number11
DOIs
Publication statusPublished - 01-11-2008

Fingerprint

Reducing Diet
Adrenergic Receptors
Body Weight
Confidence Intervals
Exercise
Weight Loss
Genes
Body Weight Changes
Tryptophan
Arginine
Diet
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Kuriyama, Shinichi ; Shimazu, Taichi ; Hozawa, Atsushi ; Kure, Shigeo ; Kurokawa, Naoyuki ; Kakizaki, Masako ; Sone, Toshimasa ; Matsuda-Ohmori, Kaori ; Nakaya, Naoki ; Satoh, Hiroshi ; Tsuji, Ichiro. / No effect of the Trp64Arg variant of the β3-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adults. In: Metabolism: Clinical and Experimental. 2008 ; Vol. 57, No. 11. pp. 1570-1575.
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abstract = "Controversy remains as to whether the presence of the tryptophan-to-arginine (Trp64Arg) variant of the β3-adrenergic receptor gene impedes the magnitude of body weight loss by diet and exercise intervention. The objectives of the present study were to compare the changes in body weight between carriers and noncarriers of the Trp64Arg variant before and after 6 months of diet and exercise interventions for weight loss. A total of 37 middle-aged Japanese individuals (12 carriers and 25 noncarriers of the Trp64Arg variant) participated in the study. There were no significant differences in body weight between the 2 groups at the baseline. There were significant reductions in body weight both in carriers and noncarriers, but no significant differences between the 2 groups with respect to changes in these variables. The weight changes were -2.52 kg (95{\%} confidence interval [CI], -3.56 to -1.48) among carriers and -1.89 kg (95{\%} CI, -2.65 to -1.13) among noncarriers, and the change in the variant carrier group minus the change in the variant noncarrier group was -0.47 (95{\%} CI, -1.97 to 1.02). These results suggest that the presence of the Trp64Arg variant of the β3-adrenergic receptor gene may not play a major role as a hindrance to weight reduction.",
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Kuriyama, S, Shimazu, T, Hozawa, A, Kure, S, Kurokawa, N, Kakizaki, M, Sone, T, Matsuda-Ohmori, K, Nakaya, N, Satoh, H & Tsuji, I 2008, 'No effect of the Trp64Arg variant of the β3-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adults', Metabolism: Clinical and Experimental, vol. 57, no. 11, pp. 1570-1575. https://doi.org/10.1016/j.metabol.2008.06.013

No effect of the Trp64Arg variant of the β3-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adults. / Kuriyama, Shinichi; Shimazu, Taichi; Hozawa, Atsushi; Kure, Shigeo; Kurokawa, Naoyuki; Kakizaki, Masako; Sone, Toshimasa; Matsuda-Ohmori, Kaori; Nakaya, Naoki; Satoh, Hiroshi; Tsuji, Ichiro.

In: Metabolism: Clinical and Experimental, Vol. 57, No. 11, 01.11.2008, p. 1570-1575.

Research output: Contribution to journalArticle

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T1 - No effect of the Trp64Arg variant of the β3-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adults

AU - Kuriyama, Shinichi

AU - Shimazu, Taichi

AU - Hozawa, Atsushi

AU - Kure, Shigeo

AU - Kurokawa, Naoyuki

AU - Kakizaki, Masako

AU - Sone, Toshimasa

AU - Matsuda-Ohmori, Kaori

AU - Nakaya, Naoki

AU - Satoh, Hiroshi

AU - Tsuji, Ichiro

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N2 - Controversy remains as to whether the presence of the tryptophan-to-arginine (Trp64Arg) variant of the β3-adrenergic receptor gene impedes the magnitude of body weight loss by diet and exercise intervention. The objectives of the present study were to compare the changes in body weight between carriers and noncarriers of the Trp64Arg variant before and after 6 months of diet and exercise interventions for weight loss. A total of 37 middle-aged Japanese individuals (12 carriers and 25 noncarriers of the Trp64Arg variant) participated in the study. There were no significant differences in body weight between the 2 groups at the baseline. There were significant reductions in body weight both in carriers and noncarriers, but no significant differences between the 2 groups with respect to changes in these variables. The weight changes were -2.52 kg (95% confidence interval [CI], -3.56 to -1.48) among carriers and -1.89 kg (95% CI, -2.65 to -1.13) among noncarriers, and the change in the variant carrier group minus the change in the variant noncarrier group was -0.47 (95% CI, -1.97 to 1.02). These results suggest that the presence of the Trp64Arg variant of the β3-adrenergic receptor gene may not play a major role as a hindrance to weight reduction.

AB - Controversy remains as to whether the presence of the tryptophan-to-arginine (Trp64Arg) variant of the β3-adrenergic receptor gene impedes the magnitude of body weight loss by diet and exercise intervention. The objectives of the present study were to compare the changes in body weight between carriers and noncarriers of the Trp64Arg variant before and after 6 months of diet and exercise interventions for weight loss. A total of 37 middle-aged Japanese individuals (12 carriers and 25 noncarriers of the Trp64Arg variant) participated in the study. There were no significant differences in body weight between the 2 groups at the baseline. There were significant reductions in body weight both in carriers and noncarriers, but no significant differences between the 2 groups with respect to changes in these variables. The weight changes were -2.52 kg (95% confidence interval [CI], -3.56 to -1.48) among carriers and -1.89 kg (95% CI, -2.65 to -1.13) among noncarriers, and the change in the variant carrier group minus the change in the variant noncarrier group was -0.47 (95% CI, -1.97 to 1.02). These results suggest that the presence of the Trp64Arg variant of the β3-adrenergic receptor gene may not play a major role as a hindrance to weight reduction.

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