TY - JOUR
T1 - No increase in cerebrospinal fluid tau protein levels in patients with vascular dementia
AU - Arai, Hiroyuki
AU - Satoh-Nakagawa, Takuma
AU - Higuchi, Makoto
AU - Morikawa, Yu Ichi
AU - Miura, Masakazu
AU - Kawakami, Hisako
AU - Seki, Hisatomo
AU - Takase, Sadao
AU - Sasaki, Hidetada
PY - 1998/11/13
Y1 - 1998/11/13
N2 - Tau protein levels in cerebrospinal fluid (CSF-tau) were determined in 29 patients with old cerebrovascular disease (CVD, 21 demented and eight non- demented), 69 patients with Alzheimer's disease (AD) and 17 age-matched normal controls. The CSF-tau level in the vascular dementia (VD) group (24.0 ± 17.0 pg/ml) was significantly lower (P < 0.0001) than that in the AD group (90.0 ± 45.3 pg/ml), but not significantly different from that in the non- demented patients with CVD (18.1 ± 10.2 pg/ml) or controls (20.3 ± 13.0 pg/ml). Among the VD patients, 1/21 exceeded a cut-off value (mean ± 2 SD of controls). Whereas 8/69 of the AD patients had CSF-tau levels below this value. These findings suggest that VD constitutes a group of dementias that can be separated from AD by normal CSF-tau levels. CSF-tau determinations in combination with other clinical findings may provide another diagnostic aid in the differential diagnosis between VD and AD.
AB - Tau protein levels in cerebrospinal fluid (CSF-tau) were determined in 29 patients with old cerebrovascular disease (CVD, 21 demented and eight non- demented), 69 patients with Alzheimer's disease (AD) and 17 age-matched normal controls. The CSF-tau level in the vascular dementia (VD) group (24.0 ± 17.0 pg/ml) was significantly lower (P < 0.0001) than that in the AD group (90.0 ± 45.3 pg/ml), but not significantly different from that in the non- demented patients with CVD (18.1 ± 10.2 pg/ml) or controls (20.3 ± 13.0 pg/ml). Among the VD patients, 1/21 exceeded a cut-off value (mean ± 2 SD of controls). Whereas 8/69 of the AD patients had CSF-tau levels below this value. These findings suggest that VD constitutes a group of dementias that can be separated from AD by normal CSF-tau levels. CSF-tau determinations in combination with other clinical findings may provide another diagnostic aid in the differential diagnosis between VD and AD.
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U2 - 10.1016/S0304-3940(98)00781-2
DO - 10.1016/S0304-3940(98)00781-2
M3 - Article
C2 - 9855368
AN - SCOPUS:0032514935
SN - 0304-3940
VL - 256
SP - 174
EP - 176
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -