No significant association between SIRT1 gene and methamphetamine-induced psychosis in the Japanese population

Taro Kishi, Yasuhisa Fukuo, Tomo Okochi, Tsuyoshi Kitajima, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Christoph U. Correll, Nakao Iwata

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives: We previously showed that the sirtuin 1 gene (SIRT1 gene), one of the clock genes, was associated with schizophrenia in a Japanese patient population. Because the symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia and because not every METH user develops psychosis, it is conceivable that METH-induced psychosis and schizophrenia have common susceptibility genes. Therefore, we conducted an analysis of the association of SIRT1 gene with METH-induced psychosis, hypothesizing a significant relationship. Methods: This paper presents a case-control study of the SIRT1 gene in 515 Japanese individuals (197 with METH-induced psychosis and 318 age-matched and sex-matched controls) with four tagging single nucleotide polymorphisms (rs12778366, rs2273773, rs4746720, and rs10997875), selected a priori using the HapMap database. Results: rs10997875 (located in the 3′ flanking region) was associated with METH-induced psychosis (unadjusted pgenotype=0.0203). However, these results became non-significant after Bonferroni correction (corrected p genotype=0.0812). In the all-marker haplotype analysis, the SIRT1 gene was not associated with METH-induced psychosis (p=0.146). Conclusion: Our findings suggest that SIRT1 gene does not contribute to the development of METH-induced psychosis in the Japanese population. However, a replication study using larger samples should be conducted to obtain conclusive results.

Original languageEnglish
Pages (from-to)445-450
Number of pages6
JournalHuman Psychopharmacology
Volume26
Issue number7
DOIs
Publication statusPublished - 01-10-2011

Fingerprint

Sirtuin 1
Methamphetamine
Psychotic Disorders
Population
Genes
Schizophrenia
HapMap Project
3' Flanking Region
Paranoid Schizophrenia
Haplotypes
Single Nucleotide Polymorphism
Case-Control Studies
Genotype
Databases

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Kishi, Taro ; Fukuo, Yasuhisa ; Okochi, Tomo ; Kitajima, Tsuyoshi ; Ujike, Hiroshi ; Inada, Toshiya ; Yamada, Mitsuhiko ; Uchimura, Naohisa ; Sora, Ichiro ; Iyo, Masaomi ; Ozaki, Norio ; Correll, Christoph U. ; Iwata, Nakao. / No significant association between SIRT1 gene and methamphetamine-induced psychosis in the Japanese population. In: Human Psychopharmacology. 2011 ; Vol. 26, No. 7. pp. 445-450.
@article{24cfeddf07c749f8b3643d10be5a8b4f,
title = "No significant association between SIRT1 gene and methamphetamine-induced psychosis in the Japanese population",
abstract = "Objectives: We previously showed that the sirtuin 1 gene (SIRT1 gene), one of the clock genes, was associated with schizophrenia in a Japanese patient population. Because the symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia and because not every METH user develops psychosis, it is conceivable that METH-induced psychosis and schizophrenia have common susceptibility genes. Therefore, we conducted an analysis of the association of SIRT1 gene with METH-induced psychosis, hypothesizing a significant relationship. Methods: This paper presents a case-control study of the SIRT1 gene in 515 Japanese individuals (197 with METH-induced psychosis and 318 age-matched and sex-matched controls) with four tagging single nucleotide polymorphisms (rs12778366, rs2273773, rs4746720, and rs10997875), selected a priori using the HapMap database. Results: rs10997875 (located in the 3′ flanking region) was associated with METH-induced psychosis (unadjusted pgenotype=0.0203). However, these results became non-significant after Bonferroni correction (corrected p genotype=0.0812). In the all-marker haplotype analysis, the SIRT1 gene was not associated with METH-induced psychosis (p=0.146). Conclusion: Our findings suggest that SIRT1 gene does not contribute to the development of METH-induced psychosis in the Japanese population. However, a replication study using larger samples should be conducted to obtain conclusive results.",
author = "Taro Kishi and Yasuhisa Fukuo and Tomo Okochi and Tsuyoshi Kitajima and Hiroshi Ujike and Toshiya Inada and Mitsuhiko Yamada and Naohisa Uchimura and Ichiro Sora and Masaomi Iyo and Norio Ozaki and Correll, {Christoph U.} and Nakao Iwata",
year = "2011",
month = "10",
day = "1",
doi = "10.1002/hup.1223",
language = "English",
volume = "26",
pages = "445--450",
journal = "Human Psychopharmacology",
issn = "0885-6222",
publisher = "John Wiley and Sons Ltd",
number = "7",

}

Kishi, T, Fukuo, Y, Okochi, T, Kitajima, T, Ujike, H, Inada, T, Yamada, M, Uchimura, N, Sora, I, Iyo, M, Ozaki, N, Correll, CU & Iwata, N 2011, 'No significant association between SIRT1 gene and methamphetamine-induced psychosis in the Japanese population', Human Psychopharmacology, vol. 26, no. 7, pp. 445-450. https://doi.org/10.1002/hup.1223

No significant association between SIRT1 gene and methamphetamine-induced psychosis in the Japanese population. / Kishi, Taro; Fukuo, Yasuhisa; Okochi, Tomo; Kitajima, Tsuyoshi; Ujike, Hiroshi; Inada, Toshiya; Yamada, Mitsuhiko; Uchimura, Naohisa; Sora, Ichiro; Iyo, Masaomi; Ozaki, Norio; Correll, Christoph U.; Iwata, Nakao.

In: Human Psychopharmacology, Vol. 26, No. 7, 01.10.2011, p. 445-450.

Research output: Contribution to journalArticle

TY - JOUR

T1 - No significant association between SIRT1 gene and methamphetamine-induced psychosis in the Japanese population

AU - Kishi, Taro

AU - Fukuo, Yasuhisa

AU - Okochi, Tomo

AU - Kitajima, Tsuyoshi

AU - Ujike, Hiroshi

AU - Inada, Toshiya

AU - Yamada, Mitsuhiko

AU - Uchimura, Naohisa

AU - Sora, Ichiro

AU - Iyo, Masaomi

AU - Ozaki, Norio

AU - Correll, Christoph U.

AU - Iwata, Nakao

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Objectives: We previously showed that the sirtuin 1 gene (SIRT1 gene), one of the clock genes, was associated with schizophrenia in a Japanese patient population. Because the symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia and because not every METH user develops psychosis, it is conceivable that METH-induced psychosis and schizophrenia have common susceptibility genes. Therefore, we conducted an analysis of the association of SIRT1 gene with METH-induced psychosis, hypothesizing a significant relationship. Methods: This paper presents a case-control study of the SIRT1 gene in 515 Japanese individuals (197 with METH-induced psychosis and 318 age-matched and sex-matched controls) with four tagging single nucleotide polymorphisms (rs12778366, rs2273773, rs4746720, and rs10997875), selected a priori using the HapMap database. Results: rs10997875 (located in the 3′ flanking region) was associated with METH-induced psychosis (unadjusted pgenotype=0.0203). However, these results became non-significant after Bonferroni correction (corrected p genotype=0.0812). In the all-marker haplotype analysis, the SIRT1 gene was not associated with METH-induced psychosis (p=0.146). Conclusion: Our findings suggest that SIRT1 gene does not contribute to the development of METH-induced psychosis in the Japanese population. However, a replication study using larger samples should be conducted to obtain conclusive results.

AB - Objectives: We previously showed that the sirtuin 1 gene (SIRT1 gene), one of the clock genes, was associated with schizophrenia in a Japanese patient population. Because the symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia and because not every METH user develops psychosis, it is conceivable that METH-induced psychosis and schizophrenia have common susceptibility genes. Therefore, we conducted an analysis of the association of SIRT1 gene with METH-induced psychosis, hypothesizing a significant relationship. Methods: This paper presents a case-control study of the SIRT1 gene in 515 Japanese individuals (197 with METH-induced psychosis and 318 age-matched and sex-matched controls) with four tagging single nucleotide polymorphisms (rs12778366, rs2273773, rs4746720, and rs10997875), selected a priori using the HapMap database. Results: rs10997875 (located in the 3′ flanking region) was associated with METH-induced psychosis (unadjusted pgenotype=0.0203). However, these results became non-significant after Bonferroni correction (corrected p genotype=0.0812). In the all-marker haplotype analysis, the SIRT1 gene was not associated with METH-induced psychosis (p=0.146). Conclusion: Our findings suggest that SIRT1 gene does not contribute to the development of METH-induced psychosis in the Japanese population. However, a replication study using larger samples should be conducted to obtain conclusive results.

UR - http://www.scopus.com/inward/record.url?scp=80755189063&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80755189063&partnerID=8YFLogxK

U2 - 10.1002/hup.1223

DO - 10.1002/hup.1223

M3 - Article

C2 - 21882241

AN - SCOPUS:80755189063

VL - 26

SP - 445

EP - 450

JO - Human Psychopharmacology

JF - Human Psychopharmacology

SN - 0885-6222

IS - 7

ER -