TY - JOUR
T1 - No significant association between SIRT1 gene and methamphetamine-induced psychosis in the Japanese population
AU - Kishi, Taro
AU - Fukuo, Yasuhisa
AU - Okochi, Tomo
AU - Kitajima, Tsuyoshi
AU - Ujike, Hiroshi
AU - Inada, Toshiya
AU - Yamada, Mitsuhiko
AU - Uchimura, Naohisa
AU - Sora, Ichiro
AU - Iyo, Masaomi
AU - Ozaki, Norio
AU - Correll, Christoph U.
AU - Iwata, Nakao
PY - 2011/10
Y1 - 2011/10
N2 - Objectives: We previously showed that the sirtuin 1 gene (SIRT1 gene), one of the clock genes, was associated with schizophrenia in a Japanese patient population. Because the symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia and because not every METH user develops psychosis, it is conceivable that METH-induced psychosis and schizophrenia have common susceptibility genes. Therefore, we conducted an analysis of the association of SIRT1 gene with METH-induced psychosis, hypothesizing a significant relationship. Methods: This paper presents a case-control study of the SIRT1 gene in 515 Japanese individuals (197 with METH-induced psychosis and 318 age-matched and sex-matched controls) with four tagging single nucleotide polymorphisms (rs12778366, rs2273773, rs4746720, and rs10997875), selected a priori using the HapMap database. Results: rs10997875 (located in the 3′ flanking region) was associated with METH-induced psychosis (unadjusted pgenotype=0.0203). However, these results became non-significant after Bonferroni correction (corrected p genotype=0.0812). In the all-marker haplotype analysis, the SIRT1 gene was not associated with METH-induced psychosis (p=0.146). Conclusion: Our findings suggest that SIRT1 gene does not contribute to the development of METH-induced psychosis in the Japanese population. However, a replication study using larger samples should be conducted to obtain conclusive results.
AB - Objectives: We previously showed that the sirtuin 1 gene (SIRT1 gene), one of the clock genes, was associated with schizophrenia in a Japanese patient population. Because the symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia and because not every METH user develops psychosis, it is conceivable that METH-induced psychosis and schizophrenia have common susceptibility genes. Therefore, we conducted an analysis of the association of SIRT1 gene with METH-induced psychosis, hypothesizing a significant relationship. Methods: This paper presents a case-control study of the SIRT1 gene in 515 Japanese individuals (197 with METH-induced psychosis and 318 age-matched and sex-matched controls) with four tagging single nucleotide polymorphisms (rs12778366, rs2273773, rs4746720, and rs10997875), selected a priori using the HapMap database. Results: rs10997875 (located in the 3′ flanking region) was associated with METH-induced psychosis (unadjusted pgenotype=0.0203). However, these results became non-significant after Bonferroni correction (corrected p genotype=0.0812). In the all-marker haplotype analysis, the SIRT1 gene was not associated with METH-induced psychosis (p=0.146). Conclusion: Our findings suggest that SIRT1 gene does not contribute to the development of METH-induced psychosis in the Japanese population. However, a replication study using larger samples should be conducted to obtain conclusive results.
UR - https://www.scopus.com/pages/publications/80755189063
UR - https://www.scopus.com/pages/publications/80755189063#tab=citedBy
U2 - 10.1002/hup.1223
DO - 10.1002/hup.1223
M3 - Article
C2 - 21882241
AN - SCOPUS:80755189063
SN - 0885-6222
VL - 26
SP - 445
EP - 450
JO - Human Psychopharmacology
JF - Human Psychopharmacology
IS - 7
ER -
