Nodular lymphocyte predominant Hodgkin lymphoma: Clincopathological study of 25 cases from Japan with a reappraisal of tissue associated macrophages

Ahmed E. Eladl, Akira Satou, Ahmed Ali Elsayed, Yuka Suzuki, Kei Shimizu-Kohno, Seiichi Kato, Akihiro Tomita, Tomohiro Kinoshita, Shigeo Nakamura, Naoko Asano

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Abstract

Clinicopathological features of 25 nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) patients in Japan were analysed. To investigate the clinicopathological significance of tissue associated macrophages (TAM) in NLPHL, CD68 and CD163 expression were investigated. The median age at onset was 56 years (range: 6-82 years) with male predominance (64%). All patients presented with lymph node enlargement with predilection for cervical LNs. Seven cases (28%) had mediastinal lesion and four (16%) had extranodal involvement. Most cases (76%) presented with early clinical stages. After median follow up of 44 months, both of overall and progression free survival rates were 95%. The presence of >5% CD68+ TAM in NLPHL was significantly associated with older age at diagnosis (median, 71 vs 52.5 years; P=0.048), lower hemoglobin level (33.3% vs 0%; P=0.037) and lower CR rate after initial treatment (42.9% vs 91.7%; P=0.038). The presence of >5% CD163+ TAM was significantly correlated with presence of B symptoms (40% vs 0%; P=0.036). In conclusion, NLPHL is rare among Japanese and appears to present at an older age than among Western patients. In our series, the presence of >5% CD68+ TAM in NLPHL was associated with lower CR rate, but with no impact on patients' survival.

Original languageEnglish
Pages (from-to)652-660
Number of pages9
JournalPathology International
Volume65
Issue number12
DOIs
Publication statusPublished - 01-12-2015
Externally publishedYes

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Hodgkin Disease
Japan
Macrophages
Age of Onset
Disease-Free Survival
Hemoglobins
Survival Rate
Lymph Nodes
Survival
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Eladl, Ahmed E. ; Satou, Akira ; Elsayed, Ahmed Ali ; Suzuki, Yuka ; Shimizu-Kohno, Kei ; Kato, Seiichi ; Tomita, Akihiro ; Kinoshita, Tomohiro ; Nakamura, Shigeo ; Asano, Naoko. / Nodular lymphocyte predominant Hodgkin lymphoma : Clincopathological study of 25 cases from Japan with a reappraisal of tissue associated macrophages. In: Pathology International. 2015 ; Vol. 65, No. 12. pp. 652-660.
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abstract = "Clinicopathological features of 25 nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) patients in Japan were analysed. To investigate the clinicopathological significance of tissue associated macrophages (TAM) in NLPHL, CD68 and CD163 expression were investigated. The median age at onset was 56 years (range: 6-82 years) with male predominance (64{\%}). All patients presented with lymph node enlargement with predilection for cervical LNs. Seven cases (28{\%}) had mediastinal lesion and four (16{\%}) had extranodal involvement. Most cases (76{\%}) presented with early clinical stages. After median follow up of 44 months, both of overall and progression free survival rates were 95{\%}. The presence of >5{\%} CD68+ TAM in NLPHL was significantly associated with older age at diagnosis (median, 71 vs 52.5 years; P=0.048), lower hemoglobin level (33.3{\%} vs 0{\%}; P=0.037) and lower CR rate after initial treatment (42.9{\%} vs 91.7{\%}; P=0.038). The presence of >5{\%} CD163+ TAM was significantly correlated with presence of B symptoms (40{\%} vs 0{\%}; P=0.036). In conclusion, NLPHL is rare among Japanese and appears to present at an older age than among Western patients. In our series, the presence of >5{\%} CD68+ TAM in NLPHL was associated with lower CR rate, but with no impact on patients' survival.",
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Eladl, AE, Satou, A, Elsayed, AA, Suzuki, Y, Shimizu-Kohno, K, Kato, S, Tomita, A, Kinoshita, T, Nakamura, S & Asano, N 2015, 'Nodular lymphocyte predominant Hodgkin lymphoma: Clincopathological study of 25 cases from Japan with a reappraisal of tissue associated macrophages', Pathology International, vol. 65, no. 12, pp. 652-660. https://doi.org/10.1111/pin.12357

Nodular lymphocyte predominant Hodgkin lymphoma : Clincopathological study of 25 cases from Japan with a reappraisal of tissue associated macrophages. / Eladl, Ahmed E.; Satou, Akira; Elsayed, Ahmed Ali; Suzuki, Yuka; Shimizu-Kohno, Kei; Kato, Seiichi; Tomita, Akihiro; Kinoshita, Tomohiro; Nakamura, Shigeo; Asano, Naoko.

In: Pathology International, Vol. 65, No. 12, 01.12.2015, p. 652-660.

Research output: Contribution to journalArticle

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T2 - Clincopathological study of 25 cases from Japan with a reappraisal of tissue associated macrophages

AU - Eladl, Ahmed E.

AU - Satou, Akira

AU - Elsayed, Ahmed Ali

AU - Suzuki, Yuka

AU - Shimizu-Kohno, Kei

AU - Kato, Seiichi

AU - Tomita, Akihiro

AU - Kinoshita, Tomohiro

AU - Nakamura, Shigeo

AU - Asano, Naoko

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Y1 - 2015/12/1

N2 - Clinicopathological features of 25 nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) patients in Japan were analysed. To investigate the clinicopathological significance of tissue associated macrophages (TAM) in NLPHL, CD68 and CD163 expression were investigated. The median age at onset was 56 years (range: 6-82 years) with male predominance (64%). All patients presented with lymph node enlargement with predilection for cervical LNs. Seven cases (28%) had mediastinal lesion and four (16%) had extranodal involvement. Most cases (76%) presented with early clinical stages. After median follow up of 44 months, both of overall and progression free survival rates were 95%. The presence of >5% CD68+ TAM in NLPHL was significantly associated with older age at diagnosis (median, 71 vs 52.5 years; P=0.048), lower hemoglobin level (33.3% vs 0%; P=0.037) and lower CR rate after initial treatment (42.9% vs 91.7%; P=0.038). The presence of >5% CD163+ TAM was significantly correlated with presence of B symptoms (40% vs 0%; P=0.036). In conclusion, NLPHL is rare among Japanese and appears to present at an older age than among Western patients. In our series, the presence of >5% CD68+ TAM in NLPHL was associated with lower CR rate, but with no impact on patients' survival.

AB - Clinicopathological features of 25 nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) patients in Japan were analysed. To investigate the clinicopathological significance of tissue associated macrophages (TAM) in NLPHL, CD68 and CD163 expression were investigated. The median age at onset was 56 years (range: 6-82 years) with male predominance (64%). All patients presented with lymph node enlargement with predilection for cervical LNs. Seven cases (28%) had mediastinal lesion and four (16%) had extranodal involvement. Most cases (76%) presented with early clinical stages. After median follow up of 44 months, both of overall and progression free survival rates were 95%. The presence of >5% CD68+ TAM in NLPHL was significantly associated with older age at diagnosis (median, 71 vs 52.5 years; P=0.048), lower hemoglobin level (33.3% vs 0%; P=0.037) and lower CR rate after initial treatment (42.9% vs 91.7%; P=0.038). The presence of >5% CD163+ TAM was significantly correlated with presence of B symptoms (40% vs 0%; P=0.036). In conclusion, NLPHL is rare among Japanese and appears to present at an older age than among Western patients. In our series, the presence of >5% CD68+ TAM in NLPHL was associated with lower CR rate, but with no impact on patients' survival.

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