Non-adhesive cyanoacrylate as an embolic material for endovascular neurosurgery

Hisayuki Oowaki, Shojiro Matsuda, Nobuyuki Sakai, Takayuki Ohta, Hiroo Iwata, Akiyo Sadato, Waro Taki, Nobuo Hashimoto, Ikada Yoshito Ikada

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

Endovascular neurosurgery is now becoming available as one of strategies for the treatment of cerebro-spinal arterio-venous malformations and aneurysms. For this treatment, a microcatheter is advanced into or close to a lesion and then an embolic material is administered through it to obliterate the lesion. N-butyl-2-cyanoacrylate (NBCA) has preferentially been used as an embolic material in Europe and America. However, its exceptionally strong adhesive force sometimes causes adhesion between the tip of the microcatheter and the artery. In this study, a new non-adhesive cyanoacrylate, isostearyl-2-cyanoacrylate (ISCA), was developed. It carries a long hydrophobic side isostearyl group with lower reactivity and adhesion than other cyanoacrylates. Its polymerization rate is, however, too low to obliterate a vascular lesion with a rapid blood flow. To increase the polymerization rate, ISCA was mixed with NBCA. As a result, the adhesive force of the mixture became extremely low, compared with that of NBCA. The viscosity of the mixture was low enough to allow its' use as an embolic material. Tissue reactions against the mixture was milder than those against NBCA. Radio-angiography became possible by mixing further with Lipiodol. The evaluation of this new embolic material with a rabbit renal artery showed that the obliteration effect of the mixture of ISCA and NBCA was excellent to use as an embolic material for clinical applications. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)1039-1046
Number of pages8
JournalBiomaterials
Volume21
Issue number10
DOIs
Publication statusPublished - 01-05-2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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