Non-thermal atmospheric pressure plasma activates lactate in Ringer's solution for anti-tumor effects

Hiromasa Tanaka, Kae Nakamura, Masaaki Mizuno, Kenji Ishikawa, Keigo Takeda, Hiroaki Kajiyama, Fumi Utsumi, Fumitaka Kikkawa, Masaru Hori

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176 Citations (Scopus)


Non-thermal atmospheric pressure plasma is a novel approach for wound healing, blood coagulation, and cancer therapy. A recent discovery in the field of plasma medicine is that non-thermal atmospheric pressure plasma not only directly but also indirectly affects cells via plasma-treated liquids. This discovery has led to the use of non-thermal atmospheric pressure plasma as a novel chemotherapy. We refer to these plasma-treated liquids as plasma-activated liquids. We chose Ringer's solutions to produce plasma-activated liquids for clinical applications. In vitro and in vivo experiments demonstrated that plasma-activated Ringer's lactate solution has anti-tumor effects, but of the four components in Ringer's lactate solution, only lactate exhibited anti-tumor effects through activation by non-thermal plasma. Nuclear magnetic resonance analyses indicate that plasma irradiation generates acetyl and pyruvic acid-like groups in Ringer's lactate solution. Overall, these results suggest that plasma-activated Ringer's lactate solution is promising for chemotherapy.

Original languageEnglish
Article number36282
JournalScientific reports
Publication statusPublished - 08-11-2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General


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