Nonadhesive liquid embolic agent: Role of its components in histologic changes in embolized arteries

A. Sadato, Y. Numaguchi, W. Taki, H. Iwata, K. Yamashita

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Rationale and Objectives. The authors evaluated the safety and efficacy of a nonadhesive liquid embolic material and the role of its component in histologic changes in embolized arteries. Materials and Methods. A Eudragit- E mixture (Rohm Chemische Fabrik, Darmstadt, Germany) was made of a cationic copolymer (Eudragit-E) dissolved in an equal volume of absolute ethanol and iopamidol. The Eudragit-E mixture, an ethanol-iopamidol mixture, and an iopamidol-saline mixture were injected into 12 rabbit renal arteries each. Three rabbits from each group were followed up for 1 day, 1 week, 1 month, and 3 months, at which time they were sacrificed. Kidneys were removed for histologic examination. Results. The Eudragit-E mixture occluded all renal arteries without difficulty; the arteries did not recanalize. Histologically, acute vasculitis was caused by both the Eudragit-E and ethanol-iopamidol mixtures, but not by the iopamidol-saline mixture. Small infarctions were elicited with the ethanol-iopamidol mixture but not with the iopamidol- saline mixture. Conclusion. The Eudragit-E mixture is effective and easy to handle. Fifty percent ethanol may play a role in vessel occlusion with Eudragit-E mixture and in acute vasculitis.

Original languageEnglish
Pages (from-to)198-206
Number of pages9
JournalAcademic Radiology
Issue number3
Publication statusPublished - 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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