TY - JOUR
T1 - Nosocomial infection with rotavirus vaccine strain in paediatric patients with immunodeficiency
AU - Miura, H.
AU - Taniguchi, K.
AU - Narita, K.
AU - Kawamura, Y.
AU - Kozawa, K.
AU - Muramatsu, H.
AU - Takahashi, Y.
AU - Ihira, M.
AU - Yoshikawa, T.
N1 - Funding Information:
This study was supported by the Japan Agency for Medical Research and Development (AMED), Japan (grant No.: 20fk0108066h1503 ).
Publisher Copyright:
© 2021 The Healthcare Infection Society
PY - 2022/3
Y1 - 2022/3
N2 - In infants with immunodeficiency, rotavirus (RV) vaccines can be continuously excreted in stool. We analysed nosocomial infection with RV vaccine strain in immunodeficient paediatric patients. RV1 RNAs were detected in stool and serum samples from case A, who was vaccinated with RV1, and case B, who was not. PAGE analysis of serial stool samples of case A revealed several rearrangements of the RV genome. In case B, the only band pattern detected was the same as a rearrangement detected in case A at the same time. In summary, RV vaccination of infants with immunodeficiency poses a risk of nosocomial infections.
AB - In infants with immunodeficiency, rotavirus (RV) vaccines can be continuously excreted in stool. We analysed nosocomial infection with RV vaccine strain in immunodeficient paediatric patients. RV1 RNAs were detected in stool and serum samples from case A, who was vaccinated with RV1, and case B, who was not. PAGE analysis of serial stool samples of case A revealed several rearrangements of the RV genome. In case B, the only band pattern detected was the same as a rearrangement detected in case A at the same time. In summary, RV vaccination of infants with immunodeficiency poses a risk of nosocomial infections.
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U2 - 10.1016/j.jhin.2021.12.009
DO - 10.1016/j.jhin.2021.12.009
M3 - Article
C2 - 34915052
AN - SCOPUS:85123173375
SN - 0195-6701
VL - 121
SP - 9
EP - 13
JO - Journal of Hospital Infection
JF - Journal of Hospital Infection
ER -