Nosocomial infection with rotavirus vaccine strain in paediatric patients with immunodeficiency

H. Miura, K. Taniguchi, K. Narita, Y. Kawamura, K. Kozawa, H. Muramatsu, Y. Takahashi, M. Ihira, T. Yoshikawa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


In infants with immunodeficiency, rotavirus (RV) vaccines can be continuously excreted in stool. We analysed nosocomial infection with RV vaccine strain in immunodeficient paediatric patients. RV1 RNAs were detected in stool and serum samples from case A, who was vaccinated with RV1, and case B, who was not. PAGE analysis of serial stool samples of case A revealed several rearrangements of the RV genome. In case B, the only band pattern detected was the same as a rearrangement detected in case A at the same time. In summary, RV vaccination of infants with immunodeficiency poses a risk of nosocomial infections.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalJournal of Hospital Infection
Publication statusPublished - 03-2022

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases


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