Novel 16S rRNA methyltransferase RmtH produced by Klebsiella pneumoniae associated with war-related trauma

Jessica A. O'Hara, Patrick McGann, Erik C. Snesrud, Robert J. Clifford, Paige E. Waterman, Emil P. Lesho, Yohei Doi

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Klebsiella pneumoniae strain MRSN2404 was isolated from the chronic wound of a soldier who had been wounded in Iraq in 2006. The strain displayed very high MICs of all aminoglycosides, including arbekacin. A gene encoding a novel 16S rRNA methyltransferase, now designated RmtH, was identified. RmtH had 64% identity with RmtB1 and RmtB2. rmtH was bracketed by two copies of ISCR2, which may have played a role in its mobilization.

Original languageEnglish
Pages (from-to)2413-2416
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume57
Issue number5
DOIs
Publication statusPublished - 01-05-2013
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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