Novel 16S rRNA methyltransferase RmtH produced by Klebsiella pneumoniae associated with war-related trauma

Jessica A. O'Hara; Patrick McGann; Erik C. Snesrud; Robert J. Clifford; Paige E. Waterman; Emil P. Lesho; Yohei Doi

doi:10.1128/AAC.00266-13

Novel 16S rRNA methyltransferase RmtH produced by Klebsiella pneumoniae associated with war-related trauma

Jessica A. O'Hara
, Patrick McGann
, Erik C. Snesrud
, Robert J. Clifford
, Paige E. Waterman
, Emil P. Lesho
, Yohei Doi

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

Klebsiella pneumoniae strain MRSN2404 was isolated from the chronic wound of a soldier who had been wounded in Iraq in 2006. The strain displayed very high MICs of all aminoglycosides, including arbekacin. A gene encoding a novel 16S rRNA methyltransferase, now designated RmtH, was identified. RmtH had 64% identity with RmtB1 and RmtB2. rmtH was bracketed by two copies of ISCR2, which may have played a role in its mobilization.

Original language	English
Pages (from-to)	2413-2416
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	57
Issue number	5
DOIs	https://doi.org/10.1128/AAC.00266-13
Publication status	Published - 05-2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.00266-13

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title = "Novel 16S rRNA methyltransferase RmtH produced by Klebsiella pneumoniae associated with war-related trauma",

abstract = "Klebsiella pneumoniae strain MRSN2404 was isolated from the chronic wound of a soldier who had been wounded in Iraq in 2006. The strain displayed very high MICs of all aminoglycosides, including arbekacin. A gene encoding a novel 16S rRNA methyltransferase, now designated RmtH, was identified. RmtH had 64\% identity with RmtB1 and RmtB2. rmtH was bracketed by two copies of ISCR2, which may have played a role in its mobilization.",

author = "O'Hara, \{Jessica A.\} and Patrick McGann and Snesrud, \{Erik C.\} and Clifford, \{Robert J.\} and Waterman, \{Paige E.\} and Lesho, \{Emil P.\} and Yohei Doi",

year = "2013",

month = may,

doi = "10.1128/AAC.00266-13",

language = "English",

volume = "57",

pages = "2413--2416",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Novel 16S rRNA methyltransferase RmtH produced by Klebsiella pneumoniae associated with war-related trauma

AU - O'Hara, Jessica A.

AU - McGann, Patrick

AU - Snesrud, Erik C.

AU - Clifford, Robert J.

AU - Waterman, Paige E.

AU - Lesho, Emil P.

AU - Doi, Yohei

PY - 2013/5

Y1 - 2013/5

N2 - Klebsiella pneumoniae strain MRSN2404 was isolated from the chronic wound of a soldier who had been wounded in Iraq in 2006. The strain displayed very high MICs of all aminoglycosides, including arbekacin. A gene encoding a novel 16S rRNA methyltransferase, now designated RmtH, was identified. RmtH had 64% identity with RmtB1 and RmtB2. rmtH was bracketed by two copies of ISCR2, which may have played a role in its mobilization.

AB - Klebsiella pneumoniae strain MRSN2404 was isolated from the chronic wound of a soldier who had been wounded in Iraq in 2006. The strain displayed very high MICs of all aminoglycosides, including arbekacin. A gene encoding a novel 16S rRNA methyltransferase, now designated RmtH, was identified. RmtH had 64% identity with RmtB1 and RmtB2. rmtH was bracketed by two copies of ISCR2, which may have played a role in its mobilization.

UR - https://www.scopus.com/pages/publications/84876237735

UR - https://www.scopus.com/pages/publications/84876237735#tab=citedBy

U2 - 10.1128/AAC.00266-13

DO - 10.1128/AAC.00266-13

M3 - Article

C2 - 23478957

AN - SCOPUS:84876237735

SN - 0066-4804

VL - 57

SP - 2413

EP - 2416

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 5

ER -

Novel 16S rRNA methyltransferase RmtH produced by Klebsiella pneumoniae associated with war-related trauma

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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