Novel 3-amino-acid-length endothelins cause constriction of vascular smooth muscle

Fumiko Kishi, Kazushi Minami, Naoko Okishima, Meiko Murakami, Sachie Mori, Mihiro Yano, Yasuharu Niwa, Yutaka Nakaya, Hiroshi Kido

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64 Citations (Scopus)


We have reported that human chymase specifically cleaves big endothelins (ETs) at the Try31-Gly32 bond, and produces novel trachea-constricting 31-amino-acid-length ETs, ETs(1-31). In this study, we investigated the effect of synthetic ETs(1-31) on the contractile activity toward porcine coronary arteries and rat aortae. Although ETs(1-31) exhibited less potent vasoconstrictile activity in these tissues than 21-amino-acid-length ETs(1-21), or a similar extent, ET-1(1-31) caused significantly slower-developing and longer-lasting contraction than ETs(1-21). The ET(A) receptor antagonist, BQ485, completely inhibited the activity of ET-1(1-31). The ET(B) receptor antagonist, BQ788, also inhibited the activity of ET-1(1-31) toward rat aortae more efficiently than that ET-1(1-21). Therefore, trachea-constricting peptides ETs(1-31) play roles as vasoconstrictors in a different manner from ETs(1-21).

Original languageEnglish
Pages (from-to)387-390
Number of pages4
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - 20-07-1998

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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