TY - JOUR
T1 - Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos
AU - Noguchi, Taka aki K.
AU - Ishimine, Hisako
AU - Nakajima, Yoshiro
AU - Watanabe-Susaki, Kanako
AU - Shigeta, Naoki
AU - Yamakawa, Norio
AU - Wang, Pi Chao
AU - Asashima, Makoto
AU - Kurisaki, Akira
N1 - Publisher Copyright:
© 2012 Elsevier B.V.
PY - 2012/4/1
Y1 - 2012/4/1
N2 - The mechanisms of gastrointestinal morphogenesis in mammals are not well understood. This is partly due to the lack of appropriate markers that are expressed with spatiotemporal specificity in the gastrointestinal tract during development. Using mouse embryos, we surveyed markers of the prospective stomach region during gastrointestinal morphogenesis. The initiation of organ bud formation occurs at E10.5 in mice. These primordia for the digestive organs protrude from a tube-like structured endoderm and have their own distinct morphogenesis. We identified 3 cell surface genes – Adra2a, Fzd5, and Trpv6 – that are expressed in the developing stomach region during gastrointestinal morphogenesis using a microarray-based screening. These novel genes will be useful in expanding our understanding of the mechanisms of gastrointestinal development.
AB - The mechanisms of gastrointestinal morphogenesis in mammals are not well understood. This is partly due to the lack of appropriate markers that are expressed with spatiotemporal specificity in the gastrointestinal tract during development. Using mouse embryos, we surveyed markers of the prospective stomach region during gastrointestinal morphogenesis. The initiation of organ bud formation occurs at E10.5 in mice. These primordia for the digestive organs protrude from a tube-like structured endoderm and have their own distinct morphogenesis. We identified 3 cell surface genes – Adra2a, Fzd5, and Trpv6 – that are expressed in the developing stomach region during gastrointestinal morphogenesis using a microarray-based screening. These novel genes will be useful in expanding our understanding of the mechanisms of gastrointestinal development.
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U2 - 10.1016/j.gep.2012.01.001
DO - 10.1016/j.gep.2012.01.001
M3 - Article
C2 - 22266179
AN - SCOPUS:84856784139
SN - 1567-133X
VL - 12
SP - 154
EP - 163
JO - Gene Expression Patterns
JF - Gene Expression Patterns
IS - 3-4
ER -