Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos

Taka aki K. Noguchi; Hisako Ishimine; Yoshiro Nakajima; Kanako Watanabe-Susaki; Naoki Shigeta; Norio Yamakawa; Pi Chao Wang; Makoto Asashima; Akira Kurisaki

doi:10.1016/j.gep.2012.01.001

Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos

Taka aki K. Noguchi
, Hisako Ishimine
, Yoshiro Nakajima
, Kanako Watanabe-Susaki
, Naoki Shigeta
, Norio Yamakawa
, Pi Chao Wang
, Makoto Asashima
, Akira Kurisaki

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The mechanisms of gastrointestinal morphogenesis in mammals are not well understood. This is partly due to the lack of appropriate markers that are expressed with spatiotemporal specificity in the gastrointestinal tract during development. Using mouse embryos, we surveyed markers of the prospective stomach region during gastrointestinal morphogenesis. The initiation of organ bud formation occurs at E10.5 in mice. These primordia for the digestive organs protrude from a tube-like structured endoderm and have their own distinct morphogenesis. We identified 3 cell surface genes – Adra2a, Fzd5, and Trpv6 – that are expressed in the developing stomach region during gastrointestinal morphogenesis using a microarray-based screening. These novel genes will be useful in expanding our understanding of the mechanisms of gastrointestinal development.

Original language	English
Pages (from-to)	154-163
Number of pages	10
Journal	Gene Expression Patterns
Volume	12
Issue number	3-4
DOIs	https://doi.org/10.1016/j.gep.2012.01.001
Publication status	Published - 01-04-2012
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics
Developmental Biology

Access to Document

10.1016/j.gep.2012.01.001

Cite this

@article{ebddd3aee9084b9c8f306c7fe0b71f04,

title = "Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos",

abstract = "The mechanisms of gastrointestinal morphogenesis in mammals are not well understood. This is partly due to the lack of appropriate markers that are expressed with spatiotemporal specificity in the gastrointestinal tract during development. Using mouse embryos, we surveyed markers of the prospective stomach region during gastrointestinal morphogenesis. The initiation of organ bud formation occurs at E10.5 in mice. These primordia for the digestive organs protrude from a tube-like structured endoderm and have their own distinct morphogenesis. We identified 3 cell surface genes – Adra2a, Fzd5, and Trpv6 – that are expressed in the developing stomach region during gastrointestinal morphogenesis using a microarray-based screening. These novel genes will be useful in expanding our understanding of the mechanisms of gastrointestinal development.",

author = "Noguchi, \{Taka aki K.\} and Hisako Ishimine and Yoshiro Nakajima and Kanako Watanabe-Susaki and Naoki Shigeta and Norio Yamakawa and Wang, \{Pi Chao\} and Makoto Asashima and Akira Kurisaki",

note = "Publisher Copyright: {\textcopyright} 2012 Elsevier B.V.",

year = "2012",

month = apr,

day = "1",

doi = "10.1016/j.gep.2012.01.001",

language = "English",

volume = "12",

pages = "154--163",

journal = "Gene Expression Patterns",

issn = "1567-133X",

publisher = "Elsevier B.V.",

number = "3-4",

}

TY - JOUR

T1 - Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos

AU - Noguchi, Taka aki K.

AU - Ishimine, Hisako

AU - Nakajima, Yoshiro

AU - Watanabe-Susaki, Kanako

AU - Shigeta, Naoki

AU - Yamakawa, Norio

AU - Wang, Pi Chao

AU - Asashima, Makoto

AU - Kurisaki, Akira

PY - 2012/4/1

Y1 - 2012/4/1

N2 - The mechanisms of gastrointestinal morphogenesis in mammals are not well understood. This is partly due to the lack of appropriate markers that are expressed with spatiotemporal specificity in the gastrointestinal tract during development. Using mouse embryos, we surveyed markers of the prospective stomach region during gastrointestinal morphogenesis. The initiation of organ bud formation occurs at E10.5 in mice. These primordia for the digestive organs protrude from a tube-like structured endoderm and have their own distinct morphogenesis. We identified 3 cell surface genes – Adra2a, Fzd5, and Trpv6 – that are expressed in the developing stomach region during gastrointestinal morphogenesis using a microarray-based screening. These novel genes will be useful in expanding our understanding of the mechanisms of gastrointestinal development.

AB - The mechanisms of gastrointestinal morphogenesis in mammals are not well understood. This is partly due to the lack of appropriate markers that are expressed with spatiotemporal specificity in the gastrointestinal tract during development. Using mouse embryos, we surveyed markers of the prospective stomach region during gastrointestinal morphogenesis. The initiation of organ bud formation occurs at E10.5 in mice. These primordia for the digestive organs protrude from a tube-like structured endoderm and have their own distinct morphogenesis. We identified 3 cell surface genes – Adra2a, Fzd5, and Trpv6 – that are expressed in the developing stomach region during gastrointestinal morphogenesis using a microarray-based screening. These novel genes will be useful in expanding our understanding of the mechanisms of gastrointestinal development.

UR - https://www.scopus.com/pages/publications/84856784139

UR - https://www.scopus.com/pages/publications/84856784139#tab=citedBy

U2 - 10.1016/j.gep.2012.01.001

DO - 10.1016/j.gep.2012.01.001

M3 - Article

C2 - 22266179

AN - SCOPUS:84856784139

SN - 1567-133X

VL - 12

SP - 154

EP - 163

JO - Gene Expression Patterns

JF - Gene Expression Patterns

IS - 3-4

ER -

Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this