Nrf2 gene promoter polymorphism and gastric carcinogenesis

Tomiyasu Arisawa, Tomomitsu Tahara, Tomoyuki Shibata, Mitsuo Nagasaka, Masakatsu Nakamura, Yoshio Kamiya, Hiroshi Fujita, Daisuke Yoshioka, Masaaki Okubo, Ichiro Hirata, Hiroshi Nakano

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background/Aims: Three gene polymorphisms of Nrf2, which regulate the expression of detoxifying and antioxidant genes, have been identified. We attempted to clarify the relationship of these polymorphisms with the carcinogenesis in the stomach. Methodology: The study was performed in 209 patients with gastric cancer and 198 patients with no evidence of gastric malignancies on upper gastroduodenal endoscopy. We employed PCR-SSCP method to detect gene polymorphisms. Results: Overall, both polymorphisms at position of -686/-684 and -650 were not significant risk factors of carcinogenesis in the stomach. However, the -686/-684 A/G allele carrier had a significantly reduced risk for gastric carcinogenesis (p=0.022), especially of diffuse type (p=0.020), in H. pylori-negative cases. The activity and inflammation scores in Nrf2 -686/-684 A/G carriers were significantly lower than those in the non-A/G carriers (p=0.038 and p=0.019, respectively). Conclusions: The -686/-684 haplotype of Nrf2 gene may be associated with the development of gastric inflammation and with gastric carcinogenesis without the influence of H. pylori infection, although overall association with gastric carcinogenesis seems to be none.

Original languageEnglish
Pages (from-to)750-754
Number of pages5
JournalHepato-gastroenterology
Volume55
Issue number82-83
Publication statusPublished - 01-03-2008

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Stomach
Carcinogenesis
Genes
Pylorus
Inflammation
Single-Stranded Conformational Polymorphism
Haplotypes
Endoscopy
Stomach Neoplasms
Antioxidants
Alleles
Polymerase Chain Reaction
Infection
Neoplasms

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y., ... Nakano, H. (2008). Nrf2 gene promoter polymorphism and gastric carcinogenesis. Hepato-gastroenterology, 55(82-83), 750-754.
Arisawa, Tomiyasu ; Tahara, Tomomitsu ; Shibata, Tomoyuki ; Nagasaka, Mitsuo ; Nakamura, Masakatsu ; Kamiya, Yoshio ; Fujita, Hiroshi ; Yoshioka, Daisuke ; Okubo, Masaaki ; Hirata, Ichiro ; Nakano, Hiroshi. / Nrf2 gene promoter polymorphism and gastric carcinogenesis. In: Hepato-gastroenterology. 2008 ; Vol. 55, No. 82-83. pp. 750-754.
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Arisawa, T, Tahara, T, Shibata, T, Nagasaka, M, Nakamura, M, Kamiya, Y, Fujita, H, Yoshioka, D, Okubo, M, Hirata, I & Nakano, H 2008, 'Nrf2 gene promoter polymorphism and gastric carcinogenesis', Hepato-gastroenterology, vol. 55, no. 82-83, pp. 750-754.

Nrf2 gene promoter polymorphism and gastric carcinogenesis. / Arisawa, Tomiyasu; Tahara, Tomomitsu; Shibata, Tomoyuki; Nagasaka, Mitsuo; Nakamura, Masakatsu; Kamiya, Yoshio; Fujita, Hiroshi; Yoshioka, Daisuke; Okubo, Masaaki; Hirata, Ichiro; Nakano, Hiroshi.

In: Hepato-gastroenterology, Vol. 55, No. 82-83, 01.03.2008, p. 750-754.

Research output: Contribution to journalArticle

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T1 - Nrf2 gene promoter polymorphism and gastric carcinogenesis

AU - Arisawa, Tomiyasu

AU - Tahara, Tomomitsu

AU - Shibata, Tomoyuki

AU - Nagasaka, Mitsuo

AU - Nakamura, Masakatsu

AU - Kamiya, Yoshio

AU - Fujita, Hiroshi

AU - Yoshioka, Daisuke

AU - Okubo, Masaaki

AU - Hirata, Ichiro

AU - Nakano, Hiroshi

PY - 2008/3/1

Y1 - 2008/3/1

N2 - Background/Aims: Three gene polymorphisms of Nrf2, which regulate the expression of detoxifying and antioxidant genes, have been identified. We attempted to clarify the relationship of these polymorphisms with the carcinogenesis in the stomach. Methodology: The study was performed in 209 patients with gastric cancer and 198 patients with no evidence of gastric malignancies on upper gastroduodenal endoscopy. We employed PCR-SSCP method to detect gene polymorphisms. Results: Overall, both polymorphisms at position of -686/-684 and -650 were not significant risk factors of carcinogenesis in the stomach. However, the -686/-684 A/G allele carrier had a significantly reduced risk for gastric carcinogenesis (p=0.022), especially of diffuse type (p=0.020), in H. pylori-negative cases. The activity and inflammation scores in Nrf2 -686/-684 A/G carriers were significantly lower than those in the non-A/G carriers (p=0.038 and p=0.019, respectively). Conclusions: The -686/-684 haplotype of Nrf2 gene may be associated with the development of gastric inflammation and with gastric carcinogenesis without the influence of H. pylori infection, although overall association with gastric carcinogenesis seems to be none.

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Arisawa T, Tahara T, Shibata T, Nagasaka M, Nakamura M, Kamiya Y et al. Nrf2 gene promoter polymorphism and gastric carcinogenesis. Hepato-gastroenterology. 2008 Mar 1;55(82-83):750-754.