Nucleotide sequence of the core region of hepatitis C virus in Pakistan and Bangladesh and the geographic characterisation of hepatitis C virus in South Asia

Tomoyoshi Ohno, Masashi Mizokami, Christopher J. Tibbs, Kayhan T. Nouri‐Aria, Rong‐Rong ‐R Wu, Ken‐Ichi ‐I Ohba, Etsuro Orito, Kaoru Suzuki, Naoto Mizoguchi, Tatsunori Nakano, Mobin Khan, Michitani Yano, Kendo Kiyosawa, Roger Williams

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A large number of complete and partial hepatitis C virus (HCV) sequences have been reported and classified into several genotypes, although none have been reported from South Asia. We have determined and evaluated partial sequences in the core region of HCV obtained from patients with chronic hepatitis in Pakistan and Bangladesh. Nucleotide sequences from these viruses show significant homology with the Japanese HCV‐TR isolate (91.7%–97.9%) and low homology with other Japanese, American, and UK isolates including HCV‐1, HC‐J4, HC‐J6, HC‐J8, and E‐b1 (79.3%–86.2%). The homologies of their deduced amino acids sequence with HCV‐1, HC‐J4, HC‐J6, HC‐J8, E‐b1, and HCV‐TR were 84.3%–89.8%, 85.0–87.9%, 84.1%–86.9%, 84.3%–87.0%, 90.2%–93.1%, and 89.8%–93.5%, respectively. These results suggest that our clones might be classified into the same genotype as HCV‐TR. Further analysis using molecular evolutionary methods strongly supported the classification of these sequences with the HCV‐TR genotype. Moreover, we could not detect any isolates which were closely related to our clones or HCV‐TR in countries outside the South Asian area. These data further support the association of HCV genotypes with distinct geographic regions. © 1994 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)362-368
Number of pages7
JournalJournal of Medical Virology
Volume44
Issue number4
DOIs
Publication statusPublished - 12-1994

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Nucleotide sequence of the core region of hepatitis C virus in Pakistan and Bangladesh and the geographic characterisation of hepatitis C virus in South Asia'. Together they form a unique fingerprint.

  • Cite this

    Ohno, T., Mizokami, M., Tibbs, C. J., Nouri‐Aria, K. T., Wu, RR. R., Ohba, KI. I., Orito, E., Suzuki, K., Mizoguchi, N., Nakano, T., Khan, M., Yano, M., Kiyosawa, K., & Williams, R. (1994). Nucleotide sequence of the core region of hepatitis C virus in Pakistan and Bangladesh and the geographic characterisation of hepatitis C virus in South Asia. Journal of Medical Virology, 44(4), 362-368. https://doi.org/10.1002/jmv.1890440409