Nucleotide sequences that distinguish Oka vaccine from parental Oka and other Varicella-Zoster virus isolates

Takele Argaw, Jeffrey I. Cohen, Michael Klutch, Kristen Lekstrom, Tetsushi Yoshikawa, Yoshizo Asano, Philip R. Krause

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

The sequences of ~34 kb from the 3' end of the varicella-zoster virus (VZV) Oka vaccine strain and the previously sequenced Dumas strain were compared. Sequence differences were noted in the coding sequences of several VZV open reading frames (ORFs), including ORFs 48, 51, 52, 55, 56, 58, 59, 60, 62, 64, and 68. Tests based on differences in the ORF62 gene and in the ORF64 poly-A region successfully distinguished the Oka vaccine strain from its wild-type parent and from other Japanese and US clinical isolates. These changes remained stable after passage of the virus in humans.

Original languageEnglish
Pages (from-to)1153-1157
Number of pages5
JournalJournal of Infectious Diseases
Volume181
Issue number3
DOIs
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

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