Nucleotide sequences that distinguish Oka vaccine from parental Oka and other Varicella-Zoster virus isolates

Takele Argaw; Jeffrey I. Cohen; Michael Klutch; Kristen Lekstrom; Tetsushi Yoshikawa; Yoshizo Asano; Philip R. Krause

doi:10.1086/315335

Nucleotide sequences that distinguish Oka vaccine from parental Oka and other Varicella-Zoster virus isolates

Takele Argaw, Jeffrey I. Cohen, Michael Klutch, Kristen Lekstrom, Tetsushi Yoshikawa, Yoshizo Asano, Philip R. Krause

Pediatrics

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

The sequences of ~34 kb from the 3' end of the varicella-zoster virus (VZV) Oka vaccine strain and the previously sequenced Dumas strain were compared. Sequence differences were noted in the coding sequences of several VZV open reading frames (ORFs), including ORFs 48, 51, 52, 55, 56, 58, 59, 60, 62, 64, and 68. Tests based on differences in the ORF62 gene and in the ORF64 poly-A region successfully distinguished the Oka vaccine strain from its wild-type parent and from other Japanese and US clinical isolates. These changes remained stable after passage of the virus in humans.

Original language	English
Pages (from-to)	1153-1157
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	181
Issue number	3
DOIs	https://doi.org/10.1086/315335
Publication status	Published - 2000

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1086/315335

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title = "Nucleotide sequences that distinguish Oka vaccine from parental Oka and other Varicella-Zoster virus isolates",

abstract = "The sequences of ~34 kb from the 3' end of the varicella-zoster virus (VZV) Oka vaccine strain and the previously sequenced Dumas strain were compared. Sequence differences were noted in the coding sequences of several VZV open reading frames (ORFs), including ORFs 48, 51, 52, 55, 56, 58, 59, 60, 62, 64, and 68. Tests based on differences in the ORF62 gene and in the ORF64 poly-A region successfully distinguished the Oka vaccine strain from its wild-type parent and from other Japanese and US clinical isolates. These changes remained stable after passage of the virus in humans.",

author = "Takele Argaw and Cohen, {Jeffrey I.} and Michael Klutch and Kristen Lekstrom and Tetsushi Yoshikawa and Yoshizo Asano and Krause, {Philip R.}",

note = "Funding Information: Grant support: National Vaccine Program via an appointment to the postgraduate research participation program at the Center for Biologics Evaluation and Research that was administered by the Oak Ridge Institute for Science and Education through the interagency agreement between the US Department of Energy and the Food and Drug Administration (FDA).",

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language = "English",

volume = "181",

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T1 - Nucleotide sequences that distinguish Oka vaccine from parental Oka and other Varicella-Zoster virus isolates

AU - Argaw, Takele

AU - Cohen, Jeffrey I.

AU - Klutch, Michael

AU - Lekstrom, Kristen

AU - Yoshikawa, Tetsushi

AU - Asano, Yoshizo

AU - Krause, Philip R.

N1 - Funding Information: Grant support: National Vaccine Program via an appointment to the postgraduate research participation program at the Center for Biologics Evaluation and Research that was administered by the Oak Ridge Institute for Science and Education through the interagency agreement between the US Department of Energy and the Food and Drug Administration (FDA).

PY - 2000

Y1 - 2000

N2 - The sequences of ~34 kb from the 3' end of the varicella-zoster virus (VZV) Oka vaccine strain and the previously sequenced Dumas strain were compared. Sequence differences were noted in the coding sequences of several VZV open reading frames (ORFs), including ORFs 48, 51, 52, 55, 56, 58, 59, 60, 62, 64, and 68. Tests based on differences in the ORF62 gene and in the ORF64 poly-A region successfully distinguished the Oka vaccine strain from its wild-type parent and from other Japanese and US clinical isolates. These changes remained stable after passage of the virus in humans.

AB - The sequences of ~34 kb from the 3' end of the varicella-zoster virus (VZV) Oka vaccine strain and the previously sequenced Dumas strain were compared. Sequence differences were noted in the coding sequences of several VZV open reading frames (ORFs), including ORFs 48, 51, 52, 55, 56, 58, 59, 60, 62, 64, and 68. Tests based on differences in the ORF62 gene and in the ORF64 poly-A region successfully distinguished the Oka vaccine strain from its wild-type parent and from other Japanese and US clinical isolates. These changes remained stable after passage of the virus in humans.

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Nucleotide sequences that distinguish Oka vaccine from parental Oka and other Varicella-Zoster virus isolates

Abstract

All Science Journal Classification (ASJC) codes

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