Obesity/weight gain and breast cancer risk: Findings from the Japan collaborative cohort study for the evaluation of cancer risk

Sadao Suzuki, Masayo Kojima, Shinkan Tokudome, Mitsuru Mori, Fumio Sakauchi, Kenji Wakai, Yoshihisa Fujino, Yingsong Lin, Shogo Kikuchi, Koji Tamakoshi, Akiko Tamakoshi, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Michiko Kurosawa, Yoshiharu Hoshiyama, Naohito Tanabe, Shuji HashimotoYasuhiko Wada, Takashi Kawamura, Yoshiyuki Watanabe, Kotaro Ozasa, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Yoichi Kurozawa, Akira Shibata, Naoyuki Okamoto, Hideo Shio

Research output: Contribution to journalArticle

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Abstract

Background: We analyzed data from the Japan Collaborative Cohort Study (36 164 women aged 40-79 years at baseline in 1988-1990 with no previous diagnosis of breast cancer and available information on weight and height) to examine the association between baseline body mass index (BMI)/weight gain from age 20 years and breast cancer risk in a non-Western population. Methods: The participants were followed prospectively from enrollment until 1999-2003 (median follow-up: 12.3 years). During follow-up, breast cancer incidence was mainly confirmed through record linkage to population-based cancer registries. A Cox proportional hazards model was used to calculate hazard ratios (HRs) and 95% CIs for the association between breast cancer risk and body size. Results: In 397 644.1 person-years of follow-up, we identified 234 breast cancer cases. Among postmenopausal women, the adjusted HR increased with BMI, with a significant linear trend (P < 0.0001). Risk was significantly increased among women with a BMI of 24 or higher (HR: 1.50, 95% CI: 1.09-2.08 for BMI of 24-28.9, and 2.13, 1.09-4.16 for BMI ≥ 29) as compared with women with a BMI of 20 to 23.9. Weight gain after age 20 years and consequent overweight/obesity were combined risk factors for postmenopausal breast cancer risk. This combined effect was stronger among women aged 60 years or older. However, the HRs were not significant in premenopausal women. Conclusions: Our findings support the hypothesis that weight gain and consequent overweight/obesity are combined risk factors for breast cancer among postmenopausal women, particularly those aged 60 years or older

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalJournal of epidemiology
Volume23
Issue number2
DOIs
Publication statusPublished - 01-01-2013

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Weight Gain
Japan
Cohort Studies
Obesity
Breast Neoplasms
Body Mass Index
Neoplasms
Body Size
Proportional Hazards Models
Population
Registries
Weights and Measures
Incidence

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Suzuki, Sadao ; Kojima, Masayo ; Tokudome, Shinkan ; Mori, Mitsuru ; Sakauchi, Fumio ; Wakai, Kenji ; Fujino, Yoshihisa ; Lin, Yingsong ; Kikuchi, Shogo ; Tamakoshi, Koji ; Tamakoshi, Akiko ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Kurosawa, Michiko ; Hoshiyama, Yoshiharu ; Tanabe, Naohito ; Hashimoto, Shuji ; Wada, Yasuhiko ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Ozasa, Kotaro ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Kurozawa, Yoichi ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo. / Obesity/weight gain and breast cancer risk : Findings from the Japan collaborative cohort study for the evaluation of cancer risk. In: Journal of epidemiology. 2013 ; Vol. 23, No. 2. pp. 139-145.
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title = "Obesity/weight gain and breast cancer risk: Findings from the Japan collaborative cohort study for the evaluation of cancer risk",
abstract = "Background: We analyzed data from the Japan Collaborative Cohort Study (36 164 women aged 40-79 years at baseline in 1988-1990 with no previous diagnosis of breast cancer and available information on weight and height) to examine the association between baseline body mass index (BMI)/weight gain from age 20 years and breast cancer risk in a non-Western population. Methods: The participants were followed prospectively from enrollment until 1999-2003 (median follow-up: 12.3 years). During follow-up, breast cancer incidence was mainly confirmed through record linkage to population-based cancer registries. A Cox proportional hazards model was used to calculate hazard ratios (HRs) and 95{\%} CIs for the association between breast cancer risk and body size. Results: In 397 644.1 person-years of follow-up, we identified 234 breast cancer cases. Among postmenopausal women, the adjusted HR increased with BMI, with a significant linear trend (P < 0.0001). Risk was significantly increased among women with a BMI of 24 or higher (HR: 1.50, 95{\%} CI: 1.09-2.08 for BMI of 24-28.9, and 2.13, 1.09-4.16 for BMI ≥ 29) as compared with women with a BMI of 20 to 23.9. Weight gain after age 20 years and consequent overweight/obesity were combined risk factors for postmenopausal breast cancer risk. This combined effect was stronger among women aged 60 years or older. However, the HRs were not significant in premenopausal women. Conclusions: Our findings support the hypothesis that weight gain and consequent overweight/obesity are combined risk factors for breast cancer among postmenopausal women, particularly those aged 60 years or older",
author = "Sadao Suzuki and Masayo Kojima and Shinkan Tokudome and Mitsuru Mori and Fumio Sakauchi and Kenji Wakai and Yoshihisa Fujino and Yingsong Lin and Shogo Kikuchi and Koji Tamakoshi and Akiko Tamakoshi and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Michiko Kurosawa and Yoshiharu Hoshiyama and Naohito Tanabe and Shuji Hashimoto and Yasuhiko Wada and Takashi Kawamura and Yoshiyuki Watanabe and Kotaro Ozasa and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Yoichi Kurozawa and Akira Shibata and Naoyuki Okamoto and Hideo Shio",
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Suzuki, S, Kojima, M, Tokudome, S, Mori, M, Sakauchi, F, Wakai, K, Fujino, Y, Lin, Y, Kikuchi, S, Tamakoshi, K, Tamakoshi, A, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Kurosawa, M, Hoshiyama, Y, Tanabe, N, Hashimoto, S, Wada, Y, Kawamura, T, Watanabe, Y, Ozasa, K, Miki, T, Date, C, Sakata, K, Kurozawa, Y, Shibata, A, Okamoto, N & Shio, H 2013, 'Obesity/weight gain and breast cancer risk: Findings from the Japan collaborative cohort study for the evaluation of cancer risk', Journal of epidemiology, vol. 23, no. 2, pp. 139-145. https://doi.org/10.2188/jea.JE20120102

Obesity/weight gain and breast cancer risk : Findings from the Japan collaborative cohort study for the evaluation of cancer risk. / Suzuki, Sadao; Kojima, Masayo; Tokudome, Shinkan; Mori, Mitsuru; Sakauchi, Fumio; Wakai, Kenji; Fujino, Yoshihisa; Lin, Yingsong; Kikuchi, Shogo; Tamakoshi, Koji; Tamakoshi, Akiko; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Kurosawa, Michiko; Hoshiyama, Yoshiharu; Tanabe, Naohito; Hashimoto, Shuji; Wada, Yasuhiko; Kawamura, Takashi; Watanabe, Yoshiyuki; Ozasa, Kotaro; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Kurozawa, Yoichi; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo.

In: Journal of epidemiology, Vol. 23, No. 2, 01.01.2013, p. 139-145.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Obesity/weight gain and breast cancer risk

T2 - Findings from the Japan collaborative cohort study for the evaluation of cancer risk

AU - Suzuki, Sadao

AU - Kojima, Masayo

AU - Tokudome, Shinkan

AU - Mori, Mitsuru

AU - Sakauchi, Fumio

AU - Wakai, Kenji

AU - Fujino, Yoshihisa

AU - Lin, Yingsong

AU - Kikuchi, Shogo

AU - Tamakoshi, Koji

AU - Tamakoshi, Akiko

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Kurosawa, Michiko

AU - Hoshiyama, Yoshiharu

AU - Tanabe, Naohito

AU - Hashimoto, Shuji

AU - Wada, Yasuhiko

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Ozasa, Kotaro

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Kurozawa, Yoichi

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Background: We analyzed data from the Japan Collaborative Cohort Study (36 164 women aged 40-79 years at baseline in 1988-1990 with no previous diagnosis of breast cancer and available information on weight and height) to examine the association between baseline body mass index (BMI)/weight gain from age 20 years and breast cancer risk in a non-Western population. Methods: The participants were followed prospectively from enrollment until 1999-2003 (median follow-up: 12.3 years). During follow-up, breast cancer incidence was mainly confirmed through record linkage to population-based cancer registries. A Cox proportional hazards model was used to calculate hazard ratios (HRs) and 95% CIs for the association between breast cancer risk and body size. Results: In 397 644.1 person-years of follow-up, we identified 234 breast cancer cases. Among postmenopausal women, the adjusted HR increased with BMI, with a significant linear trend (P < 0.0001). Risk was significantly increased among women with a BMI of 24 or higher (HR: 1.50, 95% CI: 1.09-2.08 for BMI of 24-28.9, and 2.13, 1.09-4.16 for BMI ≥ 29) as compared with women with a BMI of 20 to 23.9. Weight gain after age 20 years and consequent overweight/obesity were combined risk factors for postmenopausal breast cancer risk. This combined effect was stronger among women aged 60 years or older. However, the HRs were not significant in premenopausal women. Conclusions: Our findings support the hypothesis that weight gain and consequent overweight/obesity are combined risk factors for breast cancer among postmenopausal women, particularly those aged 60 years or older

AB - Background: We analyzed data from the Japan Collaborative Cohort Study (36 164 women aged 40-79 years at baseline in 1988-1990 with no previous diagnosis of breast cancer and available information on weight and height) to examine the association between baseline body mass index (BMI)/weight gain from age 20 years and breast cancer risk in a non-Western population. Methods: The participants were followed prospectively from enrollment until 1999-2003 (median follow-up: 12.3 years). During follow-up, breast cancer incidence was mainly confirmed through record linkage to population-based cancer registries. A Cox proportional hazards model was used to calculate hazard ratios (HRs) and 95% CIs for the association between breast cancer risk and body size. Results: In 397 644.1 person-years of follow-up, we identified 234 breast cancer cases. Among postmenopausal women, the adjusted HR increased with BMI, with a significant linear trend (P < 0.0001). Risk was significantly increased among women with a BMI of 24 or higher (HR: 1.50, 95% CI: 1.09-2.08 for BMI of 24-28.9, and 2.13, 1.09-4.16 for BMI ≥ 29) as compared with women with a BMI of 20 to 23.9. Weight gain after age 20 years and consequent overweight/obesity were combined risk factors for postmenopausal breast cancer risk. This combined effect was stronger among women aged 60 years or older. However, the HRs were not significant in premenopausal women. Conclusions: Our findings support the hypothesis that weight gain and consequent overweight/obesity are combined risk factors for breast cancer among postmenopausal women, particularly those aged 60 years or older

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