Objective evaluation of the correction by non-rigid registration of abdominal organ motion in low-dose 4D dynamic contrast-enhanced CT

Jim Piper, Yoshihiro Ikeda, Yasuko Fujisawa, Yoshiharu Ohno, Takeshi Yoshikawa, Alison Oneil, Ian Poole

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

We objectively evaluate a straightforward registration method for correcting respiration-induced movement of abdominal organs in CT perfusion studies by measuring the distributions of alignment errors between corresponding landmark pairs. We introduce the concept and describe the advantages of using the surface-normal component of distance between pairs of corresponding landmarks selected so that their surface normal is in one of the three coordinate axis directions, and show that such landmarks can be precisely placed with respect to the surface normal. Using a large population of landmark pairs on a substantial quantity of 4D dynamic contrast-enhanced CT volume data, we quantify the average alignment errors of abdominal organs that remain uncorrected by registration.

Original languageEnglish
Pages (from-to)1701-1715
Number of pages15
JournalPhysics in Medicine and Biology
Volume57
Issue number6
DOIs
Publication statusPublished - 21-03-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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