Occlusion of Experimental Aneurysms with Heparin-loaded, Microporous Stent Grafts

Shogo Nishi, Yasuhide Nakayama, Hatsue Ishibashi-Ueda, Takehisa Matsuda, David Fiorella, Felipe C. Albuquerque, Mark R. Harrigan, L. Nelson Hopkins, Sean Cullen, Randall T. Higashida, Akiyo Sadato, Nobuo Hashimoto

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

OBJECTIVE: An embolization technique using a stent graft has been developed to replace the conventional type of direct surgery or neurointervention with platinum coils and/or bare stents. The utility of a commercially available metal stent wrapped with a microporous elastomeric film coated with a thin, heparin-loaded, photocured gelatinous layer for the treatment of experimental carotid artery sidewall aneurysms in dogs was evaluated. METHODS: The stent graft was used for embolization of experimental carotid artery aneurysms in dogs. The aneurysms were prepared bilaterally in canine carotid arteries with branching of an external jugular vein patch. RESULTS: The entries into all of the aneurysms were occluded immediately after placement of the stent grafts, and the aneurysms were embolized by thrombus formation even 1 week after deployment. All of the parent carotid arteries in which stent grafts were placed were patent, without severe stenosis, immediately (n = 2), 1 week (n = 4), 1 month (n = 3), and 3 months (n = 4) after placement. Scanning electron microscopy demonstrated that the luminal surfaces of the stent grafts were entirely endothelialized as soon as 1 week after placement, via transmural tissue ingrowth through the micropores formed in the covering film. CONCLUSION: The stent graft we have developed seems to be highly promising for the treatment of aneurysms, especially with respect to immediate termination of blood inflow for aneurysm occlusion and rapid endothelialization in the aneurysm neck.

Original languageEnglish
Pages (from-to)1397-1405
Number of pages9
JournalNeurosurgery
Volume53
Issue number6
DOIs
Publication statusPublished - 12-2003

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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