Ocular complications

Alicia Rovó, André Tichelli, Yoshihiro Inamoto

Research output: Chapter in Book/Report/Conference proceedingChapter


The eye is one of the targets of complications after allogeneic hematopoietic stem cell transplantation (HSCT). Most of the ocular complications after HSCT have been recognized for a long time and are well described. Dry eye syndrome after allogeneic HSCT is closely related to chronic graft-versus-host disease (cGVHD). Ocular graft-versus-host disease (GVHD) has at least three important biologic processes: lacrimal gland dysfunction, meibomian gland dysfunction, and corneoconjunctival inflammation. Ocular GVHD develops in 40-60% of patients after allogeneic HSCT. Risk factors associated with the onset of ocular GVHD included prior acute GVHD, use of mobilized blood progenitor cells, and HSCT from a female donor to a male recipient. Topical treatment plays a major role, and includes primarily lubricants and anti-inflammatory agents. Cataracts were one of the first late effects reported in patients after allogeneic HSCT. Ocular GVHD can cause prolonged morbidity affecting ADL and QOL.

Original languageEnglish
Title of host publicationBlood and Marrow Transplantation Long Term Management
Subtitle of host publicationSurvivorship after Transplant: Second Edition
Number of pages10
ISBN (Electronic)9781119612780
ISBN (Print)9781119612698
Publication statusPublished - 01-01-2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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