Off-hours presentation does not affect in-hospital mortality of Japanese patients with acute myocardial infarction: J-MINUET substudy

on behalf of J-MINUET Investigators

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background The association between patients with acute myocardial infarction (AMI) who present during off-hours and clinical outcomes has not been fully elucidated. Methods We investigated 3283 consecutive patients with AMI who were selected from a prospective, nationwide, multicenter registry (J-MINUET) database comprising 28 institutions in Japan between July 2012 and March 2014 to determine the current impact of off-hours presentation on in-hospital mortality among Japanese patients with AMI. Results Among the patients, 52% presented in off-hours. Baseline characteristics were comparable, although those who presented during off-hours were younger and had a higher incidence of ST-elevation myocardial infarction and advanced Killip Class. The time from symptom onset to presentation time was shorter in off-hour patients (120 min, interquartile range 60 to 256 vs. 215 min, interquartile range 90 to 610, p < 0.0001). In contrast, 85% of patients underwent primary percutaneous coronary intervention (PCI) and door to balloon time was comparable between the groups (74 min, interquartile range 52 to 113 vs. 75 min, interquartile range 52 to 126, p = 0.34). The rates of in-hospital mortality were comparable (6.2% vs 6.8%, p = 0.39). Multivariate logistic regression analysis revealed that off-hours presentation was not significantly associated with in-hospital mortality [odds ratio (OR) 0.94; 95% CI, 0.68–1.30, p = 0.70]. Conclusion The clinical impact of presenting during off-hours or regular hours on AMI patients in Japan is comparable in contemporary practice. Trial registration UMIN Unique trial Number: UMIN000010037.

Original languageEnglish
Pages (from-to)553-558
Number of pages6
JournalJournal of cardiology
Volume70
Issue number6
DOIs
Publication statusPublished - 01-12-2017

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Hospital Mortality
Myocardial Infarction
Japan
Percutaneous Coronary Intervention
Registries
Logistic Models
Odds Ratio
Regression Analysis
Databases
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{0983ba0ed70f45c6aeb126b7cd82ce36,
title = "Off-hours presentation does not affect in-hospital mortality of Japanese patients with acute myocardial infarction: J-MINUET substudy",
abstract = "Background The association between patients with acute myocardial infarction (AMI) who present during off-hours and clinical outcomes has not been fully elucidated. Methods We investigated 3283 consecutive patients with AMI who were selected from a prospective, nationwide, multicenter registry (J-MINUET) database comprising 28 institutions in Japan between July 2012 and March 2014 to determine the current impact of off-hours presentation on in-hospital mortality among Japanese patients with AMI. Results Among the patients, 52{\%} presented in off-hours. Baseline characteristics were comparable, although those who presented during off-hours were younger and had a higher incidence of ST-elevation myocardial infarction and advanced Killip Class. The time from symptom onset to presentation time was shorter in off-hour patients (120 min, interquartile range 60 to 256 vs. 215 min, interquartile range 90 to 610, p < 0.0001). In contrast, 85{\%} of patients underwent primary percutaneous coronary intervention (PCI) and door to balloon time was comparable between the groups (74 min, interquartile range 52 to 113 vs. 75 min, interquartile range 52 to 126, p = 0.34). The rates of in-hospital mortality were comparable (6.2{\%} vs 6.8{\%}, p = 0.39). Multivariate logistic regression analysis revealed that off-hours presentation was not significantly associated with in-hospital mortality [odds ratio (OR) 0.94; 95{\%} CI, 0.68–1.30, p = 0.70]. Conclusion The clinical impact of presenting during off-hours or regular hours on AMI patients in Japan is comparable in contemporary practice. Trial registration UMIN Unique trial Number: UMIN000010037.",
author = "{on behalf of J-MINUET Investigators} and Manabu Ogita and Satoru Suwa and Hideki Ebina and Koichi Nakao and Yukio Ozaki and Yukio Ozaki and Junya Ako and Teruo Noguchi and Satoshi Yasuda and Kazuteru Fujimoto and Yasuharu Nakama and Takashi Morita and Wataru Shimizu and Yoshihiko Saito and Atsushi Hirohata and Yasuhiro Morita and Teruo Inoue and Atsunori Okamura and Masaaki Uematsu and Kazuhito Hirata and Kengo Tanabe and Yoshisato Shibata and Mafumi Owa and Seiji Hokimoto and Hiroshi Funayama and Nobuaki Kokubu and Ken Kozuma and Shiro Uemura and Tetsuya Toubaru and Keijiro Saku and Shigeru Oshima and Kunihiro Nishimura and Yoshihiro Miyamoto and Masaharu Ishihara",
year = "2017",
month = "12",
day = "1",
doi = "10.1016/j.jjcc.2017.05.006",
language = "English",
volume = "70",
pages = "553--558",
journal = "Journal of Cardiology",
issn = "0914-5087",
publisher = "Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai)",
number = "6",

}

Off-hours presentation does not affect in-hospital mortality of Japanese patients with acute myocardial infarction : J-MINUET substudy. / on behalf of J-MINUET Investigators.

In: Journal of cardiology, Vol. 70, No. 6, 01.12.2017, p. 553-558.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Off-hours presentation does not affect in-hospital mortality of Japanese patients with acute myocardial infarction

T2 - J-MINUET substudy

AU - on behalf of J-MINUET Investigators

AU - Ogita, Manabu

AU - Suwa, Satoru

AU - Ebina, Hideki

AU - Nakao, Koichi

AU - Ozaki, Yukio

AU - Ozaki, Yukio

AU - Ako, Junya

AU - Noguchi, Teruo

AU - Yasuda, Satoshi

AU - Fujimoto, Kazuteru

AU - Nakama, Yasuharu

AU - Morita, Takashi

AU - Shimizu, Wataru

AU - Saito, Yoshihiko

AU - Hirohata, Atsushi

AU - Morita, Yasuhiro

AU - Inoue, Teruo

AU - Okamura, Atsunori

AU - Uematsu, Masaaki

AU - Hirata, Kazuhito

AU - Tanabe, Kengo

AU - Shibata, Yoshisato

AU - Owa, Mafumi

AU - Hokimoto, Seiji

AU - Funayama, Hiroshi

AU - Kokubu, Nobuaki

AU - Kozuma, Ken

AU - Uemura, Shiro

AU - Toubaru, Tetsuya

AU - Saku, Keijiro

AU - Oshima, Shigeru

AU - Nishimura, Kunihiro

AU - Miyamoto, Yoshihiro

AU - Ishihara, Masaharu

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Background The association between patients with acute myocardial infarction (AMI) who present during off-hours and clinical outcomes has not been fully elucidated. Methods We investigated 3283 consecutive patients with AMI who were selected from a prospective, nationwide, multicenter registry (J-MINUET) database comprising 28 institutions in Japan between July 2012 and March 2014 to determine the current impact of off-hours presentation on in-hospital mortality among Japanese patients with AMI. Results Among the patients, 52% presented in off-hours. Baseline characteristics were comparable, although those who presented during off-hours were younger and had a higher incidence of ST-elevation myocardial infarction and advanced Killip Class. The time from symptom onset to presentation time was shorter in off-hour patients (120 min, interquartile range 60 to 256 vs. 215 min, interquartile range 90 to 610, p < 0.0001). In contrast, 85% of patients underwent primary percutaneous coronary intervention (PCI) and door to balloon time was comparable between the groups (74 min, interquartile range 52 to 113 vs. 75 min, interquartile range 52 to 126, p = 0.34). The rates of in-hospital mortality were comparable (6.2% vs 6.8%, p = 0.39). Multivariate logistic regression analysis revealed that off-hours presentation was not significantly associated with in-hospital mortality [odds ratio (OR) 0.94; 95% CI, 0.68–1.30, p = 0.70]. Conclusion The clinical impact of presenting during off-hours or regular hours on AMI patients in Japan is comparable in contemporary practice. Trial registration UMIN Unique trial Number: UMIN000010037.

AB - Background The association between patients with acute myocardial infarction (AMI) who present during off-hours and clinical outcomes has not been fully elucidated. Methods We investigated 3283 consecutive patients with AMI who were selected from a prospective, nationwide, multicenter registry (J-MINUET) database comprising 28 institutions in Japan between July 2012 and March 2014 to determine the current impact of off-hours presentation on in-hospital mortality among Japanese patients with AMI. Results Among the patients, 52% presented in off-hours. Baseline characteristics were comparable, although those who presented during off-hours were younger and had a higher incidence of ST-elevation myocardial infarction and advanced Killip Class. The time from symptom onset to presentation time was shorter in off-hour patients (120 min, interquartile range 60 to 256 vs. 215 min, interquartile range 90 to 610, p < 0.0001). In contrast, 85% of patients underwent primary percutaneous coronary intervention (PCI) and door to balloon time was comparable between the groups (74 min, interquartile range 52 to 113 vs. 75 min, interquartile range 52 to 126, p = 0.34). The rates of in-hospital mortality were comparable (6.2% vs 6.8%, p = 0.39). Multivariate logistic regression analysis revealed that off-hours presentation was not significantly associated with in-hospital mortality [odds ratio (OR) 0.94; 95% CI, 0.68–1.30, p = 0.70]. Conclusion The clinical impact of presenting during off-hours or regular hours on AMI patients in Japan is comparable in contemporary practice. Trial registration UMIN Unique trial Number: UMIN000010037.

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U2 - 10.1016/j.jjcc.2017.05.006

DO - 10.1016/j.jjcc.2017.05.006

M3 - Article

C2 - 28684209

AN - SCOPUS:85023748855

VL - 70

SP - 553

EP - 558

JO - Journal of Cardiology

JF - Journal of Cardiology

SN - 0914-5087

IS - 6

ER -