Olfactory neuroblastoma is an uncommon malignant tumor arising from the olfactory epithelium. In Japan, about seventy cases have been reported, and their prognosis is generally poor. We recently treated two cases of olfactory neuroblastoma. The first case is a 71-year-old male who complained of recurrent right epistaxis and headache. Intracranial extension of the tumor was demonstrated by computed tomography. We performed radiotherapy and chemotherapy after the skull base surgery, a right modified Denker-Watsuji operation and a left intranasal ethmoid surgery. There has been no evidence of local recurrence or metastasis for more than 8 years after the surgery. The second case is a 51-year-old female who complained of recurrent left epistaxis. After a left modified Caldwell-Luc operation, she received radiotherapy and chemotherapy. The patient is still alive 4 years later, with no evidence of recurrence or metastasis. In both cases, immunohistochemical examination was useful for the diagnosis, and a combination therapy was effective.
All Science Journal Classification (ASJC) codes