Olfactory neuroblastoma; A report of two cases

Ichiro Tateya, Morimasa Kitamura, Masahiko Hayashi, Masao Matsumoto, Isao Matsumoto

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Olfactory neuroblastoma is an uncommon malignant tumor arising from the olfactory epithelium. In Japan, about seventy cases have been reported, and their prognosis is generally poor. We recently treated two cases of olfactory neuroblastoma. The first case is a 71-year-old male who complained of recurrent right epistaxis and headache. Intracranial extension of the tumor was demonstrated by computed tomography. We performed radiotherapy and chemotherapy after the skull base surgery, a right modified Denker-Watsuji operation and a left intranasal ethmoid surgery. There has been no evidence of local recurrence or metastasis for more than 8 years after the surgery. The second case is a 51-year-old female who complained of recurrent left epistaxis. After a left modified Caldwell-Luc operation, she received radiotherapy and chemotherapy. The patient is still alive 4 years later, with no evidence of recurrence or metastasis. In both cases, immunohistochemical examination was useful for the diagnosis, and a combination therapy was effective.

Original languageEnglish
Pages (from-to)561-566
Number of pages6
JournalPractica Otologica
Issue number5
Publication statusPublished - 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology


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