Oncogenicity of the ret transforming gene in MMTV/ret transgenic mice

Takashi Iwamoto, Masahide Takahashi, Masafumi Ito, Michinari Hamaguchi, Ken Ichi Isobe, Nobuaki Misawa, Jun Pei Asai, Tomoaki Yoshida, Izumi Nakashima

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


We have successfully produced transgenic mice that carry the ret oncogene driven by a mouse mammary tumor virus promoter/enhancer. Mammary and salivary gland adenocarcinomas were developed in a stochastic fashion in these mice. Moreover, premalignant tumors with hyperplastic and dysplastic lesions of Harderian glands and male reproductive tracts frequently occurred at young ages. High expression of the transgene was closely associated with the development of these tumors although the levels of the transgene expression were variable among individuals. In addition, large amounts of phosphotyrosine-containing proteins were detected in cell lysales from mammary and salivary adenocarcinomas by immunoblotting with the anti-phosphotyrosine antibody.

Original languageEnglish
Pages (from-to)535-542
Number of pages8
Issue number4
Publication statusPublished - 04-1990

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research


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