Abstract
Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.
Original language | English |
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Pages (from-to) | 129-133 |
Number of pages | 5 |
Journal | European Journal of Pharmacology |
Volume | 152 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 26-07-1988 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Cellular and Molecular Neuroscience
- Pharmacology