Abstract
Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.
| Original language | English |
|---|---|
| Pages (from-to) | 129-133 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 152 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 26-07-1988 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Cellular and Molecular Neuroscience
- Pharmacology
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Opioid κ receptors correlate with the development of conditioned suppression of motility in mice. / Nabeshima, Toshitaka; Kamei, Hiroyuki; Kameyama, Tsutomu.
In: European Journal of Pharmacology, Vol. 152, No. 1-2, 26.07.1988, p. 129-133.Research output: Contribution to journal › Article
TY - JOUR
T1 - Opioid κ receptors correlate with the development of conditioned suppression of motility in mice
AU - Nabeshima, Toshitaka
AU - Kamei, Hiroyuki
AU - Kameyama, Tsutomu
PY - 1988/7/26
Y1 - 1988/7/26
N2 - Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.
AB - Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.
UR - http://www.scopus.com/inward/record.url?scp=0023749851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023749851&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(88)90843-6
DO - 10.1016/0014-2999(88)90843-6
M3 - Article
C2 - 2850197
AN - SCOPUS:0023749851
VL - 152
SP - 129
EP - 133
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1-2
ER -