Abstract
Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.
| Original language | English |
|---|---|
| Pages (from-to) | 129-133 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 152 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 26-07-1988 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Cellular and Molecular Neuroscience
- Pharmacology
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Nabeshima, T., Kamei, H., & Kameyama, T. (1988). Opioid κ receptors correlate with the development of conditioned suppression of motility in mice. European Journal of Pharmacology, 152(1-2), 129-133. https://doi.org/10.1016/0014-2999(88)90843-6