Opioid κ receptors correlate with the development of conditioned suppression of motility in mice

Toshitaka Nabeshima, Hiroyuki Kamei, Tsutomu Kameyama

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalEuropean Journal of Pharmacology
Volume152
Issue number1-2
DOIs
Publication statusPublished - 26-07-1988
Externally publishedYes

Fingerprint

Opioid Receptors
MR 2266

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

@article{1719d3707dc941b1afbd4ca6fb963bac,
title = "Opioid κ receptors correlate with the development of conditioned suppression of motility in mice",
abstract = "Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.",
author = "Toshitaka Nabeshima and Hiroyuki Kamei and Tsutomu Kameyama",
year = "1988",
month = "7",
day = "26",
doi = "10.1016/0014-2999(88)90843-6",
language = "English",
volume = "152",
pages = "129--133",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "1-2",

}

Opioid κ receptors correlate with the development of conditioned suppression of motility in mice. / Nabeshima, Toshitaka; Kamei, Hiroyuki; Kameyama, Tsutomu.

In: European Journal of Pharmacology, Vol. 152, No. 1-2, 26.07.1988, p. 129-133.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Opioid κ receptors correlate with the development of conditioned suppression of motility in mice

AU - Nabeshima, Toshitaka

AU - Kamei, Hiroyuki

AU - Kameyama, Tsutomu

PY - 1988/7/26

Y1 - 1988/7/26

N2 - Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.

AB - Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.

UR - http://www.scopus.com/inward/record.url?scp=0023749851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023749851&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(88)90843-6

DO - 10.1016/0014-2999(88)90843-6

M3 - Article

C2 - 2850197

AN - SCOPUS:0023749851

VL - 152

SP - 129

EP - 133

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1-2

ER -