Opioid κ receptors correlate with the development of conditioned suppression of motility in mice

Toshitaka Nabeshima; Hiroyuki Kamei; Tsutomu Kameyama

doi:10.1016/0014-2999(88)90843-6

Opioid κ receptors correlate with the development of conditioned suppression of motility in mice

Toshitaka Nabeshima, Hiroyuki Kamei, Tsutomu Kameyama

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.

Original language	English
Pages (from-to)	129-133
Number of pages	5
Journal	European Journal of Pharmacology
Volume	152
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-2999(88)90843-6
Publication status	Published - 26-07-1988
Externally published	Yes

All Science Journal Classification (ASJC) codes

Cellular and Molecular Neuroscience
Pharmacology

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10.1016/0014-2999(88)90843-6

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title = "Opioid κ receptors correlate with the development of conditioned suppression of motility in mice",

abstract = "Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.",

author = "Toshitaka Nabeshima and Hiroyuki Kamei and Tsutomu Kameyama",

year = "1988",

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T1 - Opioid κ receptors correlate with the development of conditioned suppression of motility in mice

AU - Nabeshima, Toshitaka

AU - Kamei, Hiroyuki

AU - Kameyama, Tsutomu

PY - 1988/7/26

Y1 - 1988/7/26

N2 - Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.

AB - Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.

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