TY - JOUR
T1 - Opioid κ receptors correlate with the development of conditioned suppression of motility in mice
AU - Nabeshima, Toshitaka
AU - Kamei, Hiroyuki
AU - Kameyama, Tsutomu
PY - 1988/7/26
Y1 - 1988/7/26
N2 - Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.
AB - Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.
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U2 - 10.1016/0014-2999(88)90843-6
DO - 10.1016/0014-2999(88)90843-6
M3 - Article
C2 - 2850197
AN - SCOPUS:0023749851
SN - 0014-2999
VL - 152
SP - 129
EP - 133
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-2
ER -