Opioid κ receptors correlate with the development of conditioned suppression of motility in mice

Toshitaka Nabeshima, Hiroyuki Kamei, Tsutomu Kameyama

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalEuropean Journal of Pharmacology
Volume152
Issue number1-2
DOIs
Publication statusPublished - 26-07-1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Pharmacology

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