TY - JOUR
T1 - Opioid needs of terminally ill patients with gynecologic malignancies
AU - Utsumi, Fumi
AU - Kajiyama, Hiroaki
AU - Sakata, Jun
AU - Higashi, Makiko
AU - Niimi, Kaoru
AU - Sekiya, Ryuichiro
AU - Mitsui, Hiroko
AU - Suzuki, Shiro
AU - Umezu, Tomokazu
AU - Mizuno, Mika
AU - Yamamoto, Eiko
AU - Shibata, Kiyosumi
AU - Kikkawa, Fumitaka
N1 - Publisher Copyright:
© 2014, Japan Society of Clinical Oncology.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Background: Little is known about patterns and predictive factors regarding opioid use for terminally ill patients with gynecologic malignancies. The aim of this study was to elucidate predictors affecting opioid requirements of end-of-life patients with gynecologic malignancies. Methods: A retrospective study was carried out on patients with gynecological malignancies admitted to our institute and died during the years 2002 to 2012. The association between maximum opioid dose and factors affecting opioid requirements were examined. Data extracted from medical records included age, site of primary cancer, maximum total dose of opioids prescribed over 24 h, the site of recurrence and metastasis, procedures performed during the hospital stay, total number of chemotherapy courses and overall survival. Results: The study identified 189 patients. Most patients had ovarian cancer (42.3 %) followed by cervical cancer (28.0 %) and then corpus malignancy (27.0 %). Opioid requirements decreased with increasing age, especially from the 50s onward. This was particularly marked in cervical cancer patients. In addition, pelvic metastasis was associated with the maximum dose of opioids and the average opioid use was highest in patients with cervical cancer. Conclusion: Young age and pelvic invasion were significant predictive factors regarding opioid requirements. Additionally, cervical cancer patients may require more opioids among those with gynecologic malignancies.
AB - Background: Little is known about patterns and predictive factors regarding opioid use for terminally ill patients with gynecologic malignancies. The aim of this study was to elucidate predictors affecting opioid requirements of end-of-life patients with gynecologic malignancies. Methods: A retrospective study was carried out on patients with gynecological malignancies admitted to our institute and died during the years 2002 to 2012. The association between maximum opioid dose and factors affecting opioid requirements were examined. Data extracted from medical records included age, site of primary cancer, maximum total dose of opioids prescribed over 24 h, the site of recurrence and metastasis, procedures performed during the hospital stay, total number of chemotherapy courses and overall survival. Results: The study identified 189 patients. Most patients had ovarian cancer (42.3 %) followed by cervical cancer (28.0 %) and then corpus malignancy (27.0 %). Opioid requirements decreased with increasing age, especially from the 50s onward. This was particularly marked in cervical cancer patients. In addition, pelvic metastasis was associated with the maximum dose of opioids and the average opioid use was highest in patients with cervical cancer. Conclusion: Young age and pelvic invasion were significant predictive factors regarding opioid requirements. Additionally, cervical cancer patients may require more opioids among those with gynecologic malignancies.
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U2 - 10.1007/s10147-014-0708-0
DO - 10.1007/s10147-014-0708-0
M3 - Article
C2 - 24906849
AN - SCOPUS:84939874480
SN - 1341-9625
VL - 20
SP - 405
EP - 410
JO - International Journal of Clinical Oncology
JF - International Journal of Clinical Oncology
IS - 2
ER -
