TY - JOUR
T1 - OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY of the FOVEAL AVASCULAR ZONE in CHILDREN with A HISTORY of TREATMENT-REQUIRING RETINOPATHY of PREMATURITY
AU - Nonobe, Norie
AU - Kaneko, Hiroki
AU - Ito, Yasuki
AU - Takayama, Kei
AU - Kataoka, Keiko
AU - Tsunekawa, Taichi
AU - Matsuura, Toshiyuki
AU - Suzumura, Ayana
AU - Shimizu, Hideyuki
AU - Terasaki, Hiroko
N1 - Publisher Copyright:
© 2019 Lippincott Williams and Wilkins. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Purpose:To examine the characteristics of the foveal vascular structure of patients with retinopathy of prematurity (ROP) by optical coherence tomography angiography.Methods:Ten patients with a history of laser photocoagulation or cryopexy treatment for Stage 3 (Zone ≥ II) ROP and 10 normal subjects (controls) were included. Foveal avascular zone, vessel density, vessel length, and vascular diameter index were measured by optical coherence tomography angiography using the 3 × 3-mm Early Treatment Diabetic Retinopathy Study (ETDRS) sectors.Results:The median foveal avascular zone values of the patients with ROP and controls were 0.103 mm2 and 0.260 mm2, respectively (P = 0.0025). The medians of the vessel density, vessel length, and vascular diameter index of the patients with ROP were 0.218 mm2/mm2, 11.75 mm/mm2, and 18.00 m, respectively, in ETDRS Sector 1 and did not significantly differ from those of the controls (P = 0.940, 0.733, and 0.705, respectively). For the average of ETDRS Sectors 2 to 5, the medians of the vessel density, vessel length, and vascular diameter index for the patients with ROP were 0.347 mm2/mm2, 18.95 mm/mm2, and 18.28 m, respectively; vessel density and vessel length were significantly smaller than those of the controls (P = 0.002 and 0.003, respectively), but there was no significant difference in vascular diameter index (P = 0.286).Conclusion:Optical coherence tomography angiography-guided foveal avascular zone was significantly smaller in patients with ROP than in controls. Our results indicate that foveal vascular development may be altered in patients with a history of treatment-requiring ROP.
AB - Purpose:To examine the characteristics of the foveal vascular structure of patients with retinopathy of prematurity (ROP) by optical coherence tomography angiography.Methods:Ten patients with a history of laser photocoagulation or cryopexy treatment for Stage 3 (Zone ≥ II) ROP and 10 normal subjects (controls) were included. Foveal avascular zone, vessel density, vessel length, and vascular diameter index were measured by optical coherence tomography angiography using the 3 × 3-mm Early Treatment Diabetic Retinopathy Study (ETDRS) sectors.Results:The median foveal avascular zone values of the patients with ROP and controls were 0.103 mm2 and 0.260 mm2, respectively (P = 0.0025). The medians of the vessel density, vessel length, and vascular diameter index of the patients with ROP were 0.218 mm2/mm2, 11.75 mm/mm2, and 18.00 m, respectively, in ETDRS Sector 1 and did not significantly differ from those of the controls (P = 0.940, 0.733, and 0.705, respectively). For the average of ETDRS Sectors 2 to 5, the medians of the vessel density, vessel length, and vascular diameter index for the patients with ROP were 0.347 mm2/mm2, 18.95 mm/mm2, and 18.28 m, respectively; vessel density and vessel length were significantly smaller than those of the controls (P = 0.002 and 0.003, respectively), but there was no significant difference in vascular diameter index (P = 0.286).Conclusion:Optical coherence tomography angiography-guided foveal avascular zone was significantly smaller in patients with ROP than in controls. Our results indicate that foveal vascular development may be altered in patients with a history of treatment-requiring ROP.
KW - foveal avascular zone
KW - optical coherence tomographic angiography
KW - retinopathy of prematurity
KW - vascular diameter index
KW - vessel density
KW - vessel length
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U2 - 10.1097/IAE.0000000000001937
DO - 10.1097/IAE.0000000000001937
M3 - Article
C2 - 29190231
AN - SCOPUS:85055925483
SN - 0275-004X
VL - 39
SP - 111
EP - 117
JO - Retina
JF - Retina
IS - 1
ER -