TY - JOUR
T1 - Oral administration of idebenone, a stimulator of NGF synthesis, recovers reduced NGF content in aged rat brain
AU - Nitta, Atsumi
AU - Hasegawa, Takaaki
AU - Nabeshima, Toshitaka
N1 - Funding Information:
The authors are grateful to Dr. Y. Furukawa and Dr. S. Furukawa, of Gifu Pharmaceutical University, for their useful advice on the NGF assay, and to Takeda Chemical Industries, Ltd. (Osaka, Japan) for the supply ofidebenone. This work was partly supported by an SRF Grant for Biomedical Research, and Grants-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan (No. 05454148), and for Gerontological Science Research from the Ministry of Health and Welfare of Japan (No. 91A-2406), and grants from the Sandoz Foundation for Gerontological Research and the Japan Research Foundation for Clinical Pharmacology.
PY - 1993/12/12
Y1 - 1993/12/12
N2 - The relationship between nerve growth factor (NGF) and senile dementia of the Alzheimer type is of interest. We demonstrate here that the oral administration of idebenone, a stimulator of NGF synthesis in vitro, produced recovery of reduced NGF content in aged rat brain. Twenty-one-day successive administration of idebenone produced significant recovery of reduced NGF content in the frontal cortex and parietal cortex of aged rats. These results suggest that NGF content in the brain is low in aged rats and that oral administration of idebenone leads to a recovery of this reduction.
AB - The relationship between nerve growth factor (NGF) and senile dementia of the Alzheimer type is of interest. We demonstrate here that the oral administration of idebenone, a stimulator of NGF synthesis in vitro, produced recovery of reduced NGF content in aged rat brain. Twenty-one-day successive administration of idebenone produced significant recovery of reduced NGF content in the frontal cortex and parietal cortex of aged rats. These results suggest that NGF content in the brain is low in aged rats and that oral administration of idebenone leads to a recovery of this reduction.
UR - http://www.scopus.com/inward/record.url?scp=0027135449&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027135449&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(93)90387-Z
DO - 10.1016/0304-3940(93)90387-Z
M3 - Article
C2 - 8309637
AN - SCOPUS:0027135449
SN - 0304-3940
VL - 163
SP - 219
EP - 222
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -