Oral administration of propentofylline, a stimulator of nerve growth factor (NGF) synthesis, recovers cholinergic neuronal dysfunction induced by the infusion of anti-NGF antibody into the rat septum

Atsumi Nitta, Yoshiko Ogihara, Joji Onishi, Takaaki Hasegawa, Shoei Furukawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We have reported that the continuous infusion of anti-nerve growth factor (NGF) monoclonal antibody into the septum of rats produces an impairment of memory and a decrease in choline acetyltransferase (ChAT) and cholinesterase (ChE) activities in the hippocampus. Propentofylline, an xanthine derivative, has potent stimulatory effects on NGF synthesis/secretion in mouse astrocytes in vitro. To investigate the pharmacological effects of propentofylline in vivo, we induced amnesia in rats by infusing anti-NGF antibody into the septum for 16 days. One group of rats was given no further treatment, while the other group was treated with propentofylline orally once a day for 19 days, commencing 3 days before the implantation of the mini-osmotic pump, and continuing throughout the period during which the animals performed the behavioral tasks. In the treated amnesic rats, learning and memory in the 3 tasks and ChAT and ChE activity were reduced compared to values in control rats. The administration of propentofylline recovered the decreased learning capacity and the deficit in cholinergic marker enzyme activity. These results suggest that the use of NGF stimulators may provide a new approach to the treatment of dementia.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalBehavioural Brain Research
Volume83
Issue number1-2
DOIs
Publication statusPublished - 01-01-1997
Externally publishedYes

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Nerve Growth Factor
Cholinergic Agents
Oral Administration
Antibodies
Choline O-Acetyltransferase
Cholinesterases
Learning
Xanthine
Amnesia
Astrocytes
Dementia
Hippocampus
Monoclonal Antibodies
propentofylline
Pharmacology
Enzymes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

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title = "Oral administration of propentofylline, a stimulator of nerve growth factor (NGF) synthesis, recovers cholinergic neuronal dysfunction induced by the infusion of anti-NGF antibody into the rat septum",
abstract = "We have reported that the continuous infusion of anti-nerve growth factor (NGF) monoclonal antibody into the septum of rats produces an impairment of memory and a decrease in choline acetyltransferase (ChAT) and cholinesterase (ChE) activities in the hippocampus. Propentofylline, an xanthine derivative, has potent stimulatory effects on NGF synthesis/secretion in mouse astrocytes in vitro. To investigate the pharmacological effects of propentofylline in vivo, we induced amnesia in rats by infusing anti-NGF antibody into the septum for 16 days. One group of rats was given no further treatment, while the other group was treated with propentofylline orally once a day for 19 days, commencing 3 days before the implantation of the mini-osmotic pump, and continuing throughout the period during which the animals performed the behavioral tasks. In the treated amnesic rats, learning and memory in the 3 tasks and ChAT and ChE activity were reduced compared to values in control rats. The administration of propentofylline recovered the decreased learning capacity and the deficit in cholinergic marker enzyme activity. These results suggest that the use of NGF stimulators may provide a new approach to the treatment of dementia.",
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Oral administration of propentofylline, a stimulator of nerve growth factor (NGF) synthesis, recovers cholinergic neuronal dysfunction induced by the infusion of anti-NGF antibody into the rat septum. / Nitta, Atsumi; Ogihara, Yoshiko; Onishi, Joji; Hasegawa, Takaaki; Furukawa, Shoei; Nabeshima, Toshitaka.

In: Behavioural Brain Research, Vol. 83, No. 1-2, 01.01.1997, p. 201-204.

Research output: Contribution to journalArticle

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