Oral mucosal adhesive film containing local anesthetics

In vitro and clinical evaluation

Keiko Yamamura, Saori Ohta, Kohji Yano, Toshihisa Yotsuyanagi, Tomomitsu Okamura, Toshitaka Nabeshima

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In vitro and in vivo studies were conducted to gauge the effectiveness of a novel oral mucosa adhesive, moderately water-soluble, pliant polymer artificial dentifrice (AD) film containing dibucaine (DC) for relief of pain due to oral erosion. The film was prepared from a hydroxypropyl cellulose-M (HPC-M) ethanol solution containing varying amounts of DC, as well as polyethylene glycol. In the in vitro experiments, the disintegration of HPC- M showed a lag time of about 50 min, a much lower rate than that of drug release, which more or less leveled off after 50 min. Twenty-five percent of the DC was released from the film (0.113 and 0.225 mg/cm2) after the initial 5 min, which then reached about 80% after 50 min, the time at which the polymer began to break up. In the in vivo study, the local anesthetic effect of the film was evaluated in 23 patients (10 males, 13 females) suffering from the adverse effects of chemotherapy. When applied to the wet surface of the mucosa, the AD film absorbed moisture and showed excellent adhesion. Pain relief in patients lasted 2.2 ± 0.21 and 4.3 ± 0.25 h at DC doses of 0.113 and 0.225 mg/cm2, respectively. These results suggest that the AD film may cover mucositis sites of oral mucosa long enough to allow DC release and bring relief from pain arising from chemotherapy and/or radiotherapy.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalJournal of Biomedical Materials Research
Volume43
Issue number3
DOIs
Publication statusPublished - 01-09-1998
Externally publishedYes

Fingerprint

Anesthetics
Dibucaine
Local Anesthetics
Adhesives
Dentifrices
Chemotherapy
Polymers
Disintegration
Radiotherapy
Polyethylene glycols
Gages
Erosion
Cellulose
Ethanol
Moisture
Adhesion
Water
Pharmaceutical Preparations
Mucous Membrane

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Yamamura, Keiko ; Ohta, Saori ; Yano, Kohji ; Yotsuyanagi, Toshihisa ; Okamura, Tomomitsu ; Nabeshima, Toshitaka. / Oral mucosal adhesive film containing local anesthetics : In vitro and clinical evaluation. In: Journal of Biomedical Materials Research. 1998 ; Vol. 43, No. 3. pp. 313-317.
@article{c8ecd7440c6d40a9972f33f0ce71118e,
title = "Oral mucosal adhesive film containing local anesthetics: In vitro and clinical evaluation",
abstract = "In vitro and in vivo studies were conducted to gauge the effectiveness of a novel oral mucosa adhesive, moderately water-soluble, pliant polymer artificial dentifrice (AD) film containing dibucaine (DC) for relief of pain due to oral erosion. The film was prepared from a hydroxypropyl cellulose-M (HPC-M) ethanol solution containing varying amounts of DC, as well as polyethylene glycol. In the in vitro experiments, the disintegration of HPC- M showed a lag time of about 50 min, a much lower rate than that of drug release, which more or less leveled off after 50 min. Twenty-five percent of the DC was released from the film (0.113 and 0.225 mg/cm2) after the initial 5 min, which then reached about 80{\%} after 50 min, the time at which the polymer began to break up. In the in vivo study, the local anesthetic effect of the film was evaluated in 23 patients (10 males, 13 females) suffering from the adverse effects of chemotherapy. When applied to the wet surface of the mucosa, the AD film absorbed moisture and showed excellent adhesion. Pain relief in patients lasted 2.2 ± 0.21 and 4.3 ± 0.25 h at DC doses of 0.113 and 0.225 mg/cm2, respectively. These results suggest that the AD film may cover mucositis sites of oral mucosa long enough to allow DC release and bring relief from pain arising from chemotherapy and/or radiotherapy.",
author = "Keiko Yamamura and Saori Ohta and Kohji Yano and Toshihisa Yotsuyanagi and Tomomitsu Okamura and Toshitaka Nabeshima",
year = "1998",
month = "9",
day = "1",
doi = "10.1002/(SICI)1097-4636(199823)43:3<313::AID-JBM12>3.0.CO;2-G",
language = "English",
volume = "43",
pages = "313--317",
journal = "Journal of Biomedical Materials Research",
issn = "0021-9304",
publisher = "Heterocorporation",
number = "3",

}

Oral mucosal adhesive film containing local anesthetics : In vitro and clinical evaluation. / Yamamura, Keiko; Ohta, Saori; Yano, Kohji; Yotsuyanagi, Toshihisa; Okamura, Tomomitsu; Nabeshima, Toshitaka.

In: Journal of Biomedical Materials Research, Vol. 43, No. 3, 01.09.1998, p. 313-317.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Oral mucosal adhesive film containing local anesthetics

T2 - In vitro and clinical evaluation

AU - Yamamura, Keiko

AU - Ohta, Saori

AU - Yano, Kohji

AU - Yotsuyanagi, Toshihisa

AU - Okamura, Tomomitsu

AU - Nabeshima, Toshitaka

PY - 1998/9/1

Y1 - 1998/9/1

N2 - In vitro and in vivo studies were conducted to gauge the effectiveness of a novel oral mucosa adhesive, moderately water-soluble, pliant polymer artificial dentifrice (AD) film containing dibucaine (DC) for relief of pain due to oral erosion. The film was prepared from a hydroxypropyl cellulose-M (HPC-M) ethanol solution containing varying amounts of DC, as well as polyethylene glycol. In the in vitro experiments, the disintegration of HPC- M showed a lag time of about 50 min, a much lower rate than that of drug release, which more or less leveled off after 50 min. Twenty-five percent of the DC was released from the film (0.113 and 0.225 mg/cm2) after the initial 5 min, which then reached about 80% after 50 min, the time at which the polymer began to break up. In the in vivo study, the local anesthetic effect of the film was evaluated in 23 patients (10 males, 13 females) suffering from the adverse effects of chemotherapy. When applied to the wet surface of the mucosa, the AD film absorbed moisture and showed excellent adhesion. Pain relief in patients lasted 2.2 ± 0.21 and 4.3 ± 0.25 h at DC doses of 0.113 and 0.225 mg/cm2, respectively. These results suggest that the AD film may cover mucositis sites of oral mucosa long enough to allow DC release and bring relief from pain arising from chemotherapy and/or radiotherapy.

AB - In vitro and in vivo studies were conducted to gauge the effectiveness of a novel oral mucosa adhesive, moderately water-soluble, pliant polymer artificial dentifrice (AD) film containing dibucaine (DC) for relief of pain due to oral erosion. The film was prepared from a hydroxypropyl cellulose-M (HPC-M) ethanol solution containing varying amounts of DC, as well as polyethylene glycol. In the in vitro experiments, the disintegration of HPC- M showed a lag time of about 50 min, a much lower rate than that of drug release, which more or less leveled off after 50 min. Twenty-five percent of the DC was released from the film (0.113 and 0.225 mg/cm2) after the initial 5 min, which then reached about 80% after 50 min, the time at which the polymer began to break up. In the in vivo study, the local anesthetic effect of the film was evaluated in 23 patients (10 males, 13 females) suffering from the adverse effects of chemotherapy. When applied to the wet surface of the mucosa, the AD film absorbed moisture and showed excellent adhesion. Pain relief in patients lasted 2.2 ± 0.21 and 4.3 ± 0.25 h at DC doses of 0.113 and 0.225 mg/cm2, respectively. These results suggest that the AD film may cover mucositis sites of oral mucosa long enough to allow DC release and bring relief from pain arising from chemotherapy and/or radiotherapy.

UR - http://www.scopus.com/inward/record.url?scp=0032171229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032171229&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-4636(199823)43:3<313::AID-JBM12>3.0.CO;2-G

DO - 10.1002/(SICI)1097-4636(199823)43:3<313::AID-JBM12>3.0.CO;2-G

M3 - Article

VL - 43

SP - 313

EP - 317

JO - Journal of Biomedical Materials Research

JF - Journal of Biomedical Materials Research

SN - 0021-9304

IS - 3

ER -