Oropharyngeal shedding of Epstein-Barr virus in the absence of circulating B cells

Susan E. Hoover; Junichi Kawada; Wyndham Wilson; Jeffrey I. Cohen

doi:10.1086/589714

Oropharyngeal shedding of Epstein-Barr virus in the absence of circulating B cells

Susan E. Hoover, Junichi Kawada, Wyndham Wilson, Jeffrey I. Cohen

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Infection with Epstein-Barr virus (EBV) results in lifelong infection of B cells in the peripheral blood and in episodic shedding of virus from the oropharynx. We monitored patients treated with rituximab (anti-CD20 monoclonal antibody) and found that several had both no detectable B cells and no EBV in the blood but shed EBV from the throat. Although some models postulate that EBV traffics from the B cells in the blood to the throat, where it is subsequently shed, our findings indicate that circulating EBV in B cells is not necessary for the virus to persist in, and to be shed from, the oropharynx.

Original language	English
Pages (from-to)	318-323
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	198
Issue number	3
DOIs	https://doi.org/10.1086/589714
Publication status	Published - 01-08-2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1086/589714

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abstract = "Infection with Epstein-Barr virus (EBV) results in lifelong infection of B cells in the peripheral blood and in episodic shedding of virus from the oropharynx. We monitored patients treated with rituximab (anti-CD20 monoclonal antibody) and found that several had both no detectable B cells and no EBV in the blood but shed EBV from the throat. Although some models postulate that EBV traffics from the B cells in the blood to the throat, where it is subsequently shed, our findings indicate that circulating EBV in B cells is not necessary for the virus to persist in, and to be shed from, the oropharynx.",

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AU - Kawada, Junichi

AU - Wilson, Wyndham

AU - Cohen, Jeffrey I.

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AB - Infection with Epstein-Barr virus (EBV) results in lifelong infection of B cells in the peripheral blood and in episodic shedding of virus from the oropharynx. We monitored patients treated with rituximab (anti-CD20 monoclonal antibody) and found that several had both no detectable B cells and no EBV in the blood but shed EBV from the throat. Although some models postulate that EBV traffics from the B cells in the blood to the throat, where it is subsequently shed, our findings indicate that circulating EBV in B cells is not necessary for the virus to persist in, and to be shed from, the oropharynx.

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Oropharyngeal shedding of Epstein-Barr virus in the absence of circulating B cells

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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