Osteopontin is involved in Th1-mediated immunity against Plasmodium falciparum infection in a holoendemic malaria region in Vietnam

Yoshimasa Maeno; Shusuke Nakazawa; Le Duc Dao; Nguyen Van Tuan; Nguyen Duc Giang; Truong Van Hanh; Koki Taniguchi

doi:10.1016/j.actatropica.2006.05.001

Osteopontin is involved in Th1-mediated immunity against Plasmodium falciparum infection in a holoendemic malaria region in Vietnam

Yoshimasa Maeno, Shusuke Nakazawa, Le Duc Dao, Nguyen Van Tuan, Nguyen Duc Giang, Truong Van Hanh, Koki Taniguchi

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

We examined the role of osteopontin (OPN) in immunity against Plasmodium falciparum infection. We measured the mRNA levels for OPN and several cytokines in RNA preparations extracted from dried blood on filter paper obtained from falciparum malaria patients in Vietnam. Expression of OPN mRNA was detected in 134 of 161 patients. The expression of both interleukin-12 p40 and interferon-γ mRNAs in the group positive for OPN mRNA was significantly higher than that in the group negative for OPN mRNA. The level of parasitemia in the OPN mRNA-positive group was much lower than that in the negative one. These results suggest that OPN might suppress multiplication of the parasites through T helper 1 cells-mediated immune responses.

Original language	English
Pages (from-to)	305-310
Number of pages	6
Journal	Acta Tropica
Volume	98
Issue number	3
DOIs	https://doi.org/10.1016/j.actatropica.2006.05.001
Publication status	Published - 07-2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Infectious Diseases
Parasitology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.actatropica.2006.05.001

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title = "Osteopontin is involved in Th1-mediated immunity against Plasmodium falciparum infection in a holoendemic malaria region in Vietnam",

abstract = "We examined the role of osteopontin (OPN) in immunity against Plasmodium falciparum infection. We measured the mRNA levels for OPN and several cytokines in RNA preparations extracted from dried blood on filter paper obtained from falciparum malaria patients in Vietnam. Expression of OPN mRNA was detected in 134 of 161 patients. The expression of both interleukin-12 p40 and interferon-γ mRNAs in the group positive for OPN mRNA was significantly higher than that in the group negative for OPN mRNA. The level of parasitemia in the OPN mRNA-positive group was much lower than that in the negative one. These results suggest that OPN might suppress multiplication of the parasites through T helper 1 cells-mediated immune responses.",

author = "Yoshimasa Maeno and Shusuke Nakazawa and Dao, {Le Duc} and {Van Tuan}, Nguyen and Giang, {Nguyen Duc} and {Van Hanh}, Truong and Koki Taniguchi",

note = "Funding Information: This work was partially supported by a Grant-in-Aid for Japan-Vietnam Collaborative Research Program from the Japan Society for the Promotion of Science, a Grant-in-Aid for Scientific Research (14570225) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and a Grant-in-Aid for Scientific Research from Fujita Health University.",

year = "2006",

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doi = "10.1016/j.actatropica.2006.05.001",

language = "English",

volume = "98",

pages = "305--310",

journal = "Acta Tropica",

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T1 - Osteopontin is involved in Th1-mediated immunity against Plasmodium falciparum infection in a holoendemic malaria region in Vietnam

AU - Maeno, Yoshimasa

AU - Nakazawa, Shusuke

AU - Dao, Le Duc

AU - Van Tuan, Nguyen

AU - Giang, Nguyen Duc

AU - Van Hanh, Truong

AU - Taniguchi, Koki

N1 - Funding Information: This work was partially supported by a Grant-in-Aid for Japan-Vietnam Collaborative Research Program from the Japan Society for the Promotion of Science, a Grant-in-Aid for Scientific Research (14570225) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and a Grant-in-Aid for Scientific Research from Fujita Health University.

PY - 2006/7

Y1 - 2006/7

N2 - We examined the role of osteopontin (OPN) in immunity against Plasmodium falciparum infection. We measured the mRNA levels for OPN and several cytokines in RNA preparations extracted from dried blood on filter paper obtained from falciparum malaria patients in Vietnam. Expression of OPN mRNA was detected in 134 of 161 patients. The expression of both interleukin-12 p40 and interferon-γ mRNAs in the group positive for OPN mRNA was significantly higher than that in the group negative for OPN mRNA. The level of parasitemia in the OPN mRNA-positive group was much lower than that in the negative one. These results suggest that OPN might suppress multiplication of the parasites through T helper 1 cells-mediated immune responses.

AB - We examined the role of osteopontin (OPN) in immunity against Plasmodium falciparum infection. We measured the mRNA levels for OPN and several cytokines in RNA preparations extracted from dried blood on filter paper obtained from falciparum malaria patients in Vietnam. Expression of OPN mRNA was detected in 134 of 161 patients. The expression of both interleukin-12 p40 and interferon-γ mRNAs in the group positive for OPN mRNA was significantly higher than that in the group negative for OPN mRNA. The level of parasitemia in the OPN mRNA-positive group was much lower than that in the negative one. These results suggest that OPN might suppress multiplication of the parasites through T helper 1 cells-mediated immune responses.

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Osteopontin is involved in Th1-mediated immunity against Plasmodium falciparum infection in a holoendemic malaria region in Vietnam

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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