Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice

Yoshimasa Maeno, Shusuke Nakazawa, Naoki Yamamoto, Masanori Shinzato, Shigeo Nagashima, Kumiko Tanaka, Jun Sasaki, Susan R. Rittling, David T. Denhardt, Toshimitsu Uede, Koki Taniguchi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.

Original languageEnglish
Pages (from-to)2423-2427
Number of pages5
JournalInfection and Immunity
Volume74
Issue number4
DOIs
Publication statusPublished - 01-04-2006

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Plasmodium chabaudi
Osteopontin
Malaria
Parasites
Infection
Interleukin-12
Knockout Mice
Interferon-gamma
Immunity

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Maeno, Yoshimasa ; Nakazawa, Shusuke ; Yamamoto, Naoki ; Shinzato, Masanori ; Nagashima, Shigeo ; Tanaka, Kumiko ; Sasaki, Jun ; Rittling, Susan R. ; Denhardt, David T. ; Uede, Toshimitsu ; Taniguchi, Koki. / Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice. In: Infection and Immunity. 2006 ; Vol. 74, No. 4. pp. 2423-2427.
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Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice. / Maeno, Yoshimasa; Nakazawa, Shusuke; Yamamoto, Naoki; Shinzato, Masanori; Nagashima, Shigeo; Tanaka, Kumiko; Sasaki, Jun; Rittling, Susan R.; Denhardt, David T.; Uede, Toshimitsu; Taniguchi, Koki.

In: Infection and Immunity, Vol. 74, No. 4, 01.04.2006, p. 2423-2427.

Research output: Contribution to journalArticle

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