Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice

Yoshimasa Maeno, Shusuke Nakazawa, Naoki Yamamoto, Masanori Shinzato, Shigeo Nagashima, Kumiko Tanaka, Jun Sasaki, Susan R. Rittling, David T. Denhardt, Toshimitsu Uede, Koki Taniguchi

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Abstract

Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.

Original languageEnglish
Pages (from-to)2423-2427
Number of pages5
JournalInfection and Immunity
Volume74
Issue number4
DOIs
Publication statusPublished - 01-04-2006

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All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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