Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice

Yoshimasa Maeno; Shusuke Nakazawa; Naoki Yamamoto; Masanori Shinzato; Shigeo Nagashima; Kumiko Tanaka; Jun Sasaki; Susan R. Rittling; David T. Denhardt; Toshimitsu Uede; Koki Taniguchi

doi:10.1128/IAI.74.4.2423-2427.2006

Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice

Yoshimasa Maeno
, Shusuke Nakazawa
, Naoki Yamamoto
, Masanori Shinzato
, Shigeo Nagashima
, Kumiko Tanaka
, Jun Sasaki
, Susan R. Rittling
, David T. Denhardt
, Toshimitsu Uede
, Koki Taniguchi

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.

Original language	English
Pages (from-to)	2423-2427
Number of pages	5
Journal	Infection and Immunity
Volume	74
Issue number	4
DOIs	https://doi.org/10.1128/IAI.74.4.2423-2427.2006
Publication status	Published - 04-2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.74.4.2423-2427.2006

Cite this

Maeno, Y., Nakazawa, S., Yamamoto, N., Shinzato, M., Nagashima, S., Tanaka, K., Sasaki, J., Rittling, S. R., Denhardt, D. T., Uede, T., & Taniguchi, K. (2006). Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice. Infection and Immunity, 74(4), 2423-2427. https://doi.org/10.1128/IAI.74.4.2423-2427.2006

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title = "Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice",

abstract = "Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.",

author = "Yoshimasa Maeno and Shusuke Nakazawa and Naoki Yamamoto and Masanori Shinzato and Shigeo Nagashima and Kumiko Tanaka and Jun Sasaki and Rittling, \{Susan R.\} and Denhardt, \{David T.\} and Toshimitsu Uede and Koki Taniguchi",

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doi = "10.1128/IAI.74.4.2423-2427.2006",

language = "English",

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}

Maeno, Y, Nakazawa, S, Yamamoto, N, Shinzato, M, Nagashima, S, Tanaka, K, Sasaki, J, Rittling, SR, Denhardt, DT, Uede, T & Taniguchi, K 2006, 'Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice', Infection and Immunity, vol. 74, no. 4, pp. 2423-2427. https://doi.org/10.1128/IAI.74.4.2423-2427.2006

TY - JOUR

T1 - Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice

AU - Maeno, Yoshimasa

AU - Nakazawa, Shusuke

AU - Yamamoto, Naoki

AU - Shinzato, Masanori

AU - Nagashima, Shigeo

AU - Tanaka, Kumiko

AU - Sasaki, Jun

AU - Rittling, Susan R.

AU - Denhardt, David T.

AU - Uede, Toshimitsu

AU - Taniguchi, Koki

PY - 2006/4

Y1 - 2006/4

N2 - Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.

AB - Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.

UR - https://www.scopus.com/pages/publications/33645529154

UR - https://www.scopus.com/pages/publications/33645529154#tab=citedBy

U2 - 10.1128/IAI.74.4.2423-2427.2006

DO - 10.1128/IAI.74.4.2423-2427.2006

M3 - Article

C2 - 16552072

AN - SCOPUS:33645529154

SN - 0019-9567

VL - 74

SP - 2423

EP - 2427

JO - Infection and Immunity

JF - Infection and Immunity

IS - 4

ER -

Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice

Abstract

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All Science Journal Classification (ASJC) codes

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