Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice

Yoshimasa Maeno; Shusuke Nakazawa; Naoki Yamamoto; Masanori Shinzato; Shigeo Nagashima; Kumiko Tanaka; Jun Sasaki; Susan R. Rittling; David T. Denhardt; Toshimitsu Uede; Koki Taniguchi

doi:10.1128/IAI.74.4.2423-2427.2006

Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice

Yoshimasa Maeno
, Shusuke Nakazawa
, Naoki Yamamoto
, Masanori Shinzato
, Shigeo Nagashima
, Kumiko Tanaka
, Jun Sasaki
, Susan R. Rittling
, David T. Denhardt
, Toshimitsu Uede
, Koki Taniguchi

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.

Original language	English
Pages (from-to)	2423-2427
Number of pages	5
Journal	Infection and Immunity
Volume	74
Issue number	4
DOIs	https://doi.org/10.1128/IAI.74.4.2423-2427.2006
Publication status	Published - 04-2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Parasitology
Microbiology
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/IAI.74.4.2423-2427.2006

Cite this

Maeno, Y., Nakazawa, S., Yamamoto, N., Shinzato, M., Nagashima, S., Tanaka, K., Sasaki, J., Rittling, S. R., Denhardt, D. T., Uede, T., & Taniguchi, K. (2006). Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice. Infection and Immunity, 74(4), 2423-2427. https://doi.org/10.1128/IAI.74.4.2423-2427.2006

@article{0be01178ac2d4308828eb6cfdbf9f1c4,

title = "Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice",

abstract = "Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.",

author = "Yoshimasa Maeno and Shusuke Nakazawa and Naoki Yamamoto and Masanori Shinzato and Shigeo Nagashima and Kumiko Tanaka and Jun Sasaki and Rittling, \{Susan R.\} and Denhardt, \{David T.\} and Toshimitsu Uede and Koki Taniguchi",

year = "2006",

month = apr,

doi = "10.1128/IAI.74.4.2423-2427.2006",

language = "English",

volume = "74",

pages = "2423--2427",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "4",

}

Maeno, Y, Nakazawa, S, Yamamoto, N, Shinzato, M, Nagashima, S, Tanaka, K, Sasaki, J, Rittling, SR, Denhardt, DT, Uede, T & Taniguchi, K 2006, 'Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice', Infection and Immunity, vol. 74, no. 4, pp. 2423-2427. https://doi.org/10.1128/IAI.74.4.2423-2427.2006

TY - JOUR

T1 - Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice

AU - Maeno, Yoshimasa

AU - Nakazawa, Shusuke

AU - Yamamoto, Naoki

AU - Shinzato, Masanori

AU - Nagashima, Shigeo

AU - Tanaka, Kumiko

AU - Sasaki, Jun

AU - Rittling, Susan R.

AU - Denhardt, David T.

AU - Uede, Toshimitsu

AU - Taniguchi, Koki

PY - 2006/4

Y1 - 2006/4

N2 - Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.

AB - Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.

UR - https://www.scopus.com/pages/publications/33645529154

UR - https://www.scopus.com/pages/publications/33645529154#tab=citedBy

U2 - 10.1128/IAI.74.4.2423-2427.2006

DO - 10.1128/IAI.74.4.2423-2427.2006

M3 - Article

C2 - 16552072

AN - SCOPUS:33645529154

SN - 0019-9567

VL - 74

SP - 2423

EP - 2427

JO - Infection and Immunity

JF - Infection and Immunity

IS - 4

ER -

Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this