TY - JOUR
T1 - Outcomes of advanced gastric cancer patients treated with chemoradiation therapy
AU - Ishigami, Sumiya
AU - Arigami, Takaaki
AU - Uenosono, Yoshikazu
AU - Okumura, Hiroshi
AU - Uchikado, Yasuto
AU - Owaki, Tetsuhiro
AU - Kijima, Yuko
AU - Nakajo, Akihiro
AU - Maemura, Kousei
AU - Ueno, Shinichi
AU - Hokita, Shuichi
AU - Hiraki, Yoshikazu
AU - Nakajo, Masataka
AU - Natsugoe, Shoji
PY - 2013/6
Y1 - 2013/6
N2 - We retrospectively analyzed 20 patients with advanced gastric cancer treated with chemoradiation (CRT). The patients consisted of 16 males and 4 females, 17 (85%) of whom received intensive chemotherapy prior to CRT. Radiation was administered concurrently at 40 to 55 Gy according to the purpose of treatment. Sixteen patients received low dose CDDP and S-1. Of 8 patients who had measurable disease, one obtained CR and 3 obtained PR by the CRT. Fifteen percent of the distinct adverse effects of CRT were grade 3 leucopenia and 30% of them were grade 3 nausea. The 2-year-survival of patients who received CRT with curative intent was 91%, significantly higher than the percentage of those with palliative intent. Four patients who received R0 surgery following CRT are postoperatively healthy without symptoms of relapse. In conclusion, even though, 75% of the patients were already given chemotherapy prior to CRT, good outcomes were achieved unexpectedly. The combination of CRT and surgery may be a useful tool for chemo-resistant, locally advanced gastric cancer.
AB - We retrospectively analyzed 20 patients with advanced gastric cancer treated with chemoradiation (CRT). The patients consisted of 16 males and 4 females, 17 (85%) of whom received intensive chemotherapy prior to CRT. Radiation was administered concurrently at 40 to 55 Gy according to the purpose of treatment. Sixteen patients received low dose CDDP and S-1. Of 8 patients who had measurable disease, one obtained CR and 3 obtained PR by the CRT. Fifteen percent of the distinct adverse effects of CRT were grade 3 leucopenia and 30% of them were grade 3 nausea. The 2-year-survival of patients who received CRT with curative intent was 91%, significantly higher than the percentage of those with palliative intent. Four patients who received R0 surgery following CRT are postoperatively healthy without symptoms of relapse. In conclusion, even though, 75% of the patients were already given chemotherapy prior to CRT, good outcomes were achieved unexpectedly. The combination of CRT and surgery may be a useful tool for chemo-resistant, locally advanced gastric cancer.
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M3 - Article
C2 - 23863647
AN - SCOPUS:84882740449
SN - 0385-0684
VL - 40
SP - 727
EP - 731
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
IS - 6
ER -