Outcomes of advanced gastric cancer patients treated with chemoradiation therapy

Sumiya Ishigami, Takaaki Arigami, Yoshikazu Uenosono, Hiroshi Okumura, Yasuto Uchikado, Tetsuhiro Owaki, Yuko Kijima, Akihiro Nakajo, Kousei Maemura, Shinichi Ueno, Shuichi Hokita, Yoshikazu Hiraki, Masataka Nakajo, Shoji Natsugoe

Research output: Contribution to journalArticle

Abstract

We retrospectively analyzed 20 patients with advanced gastric cancer treated with chemoradiation (CRT). The patients consisted of 16 males and 4 females, 17 (85%) of whom received intensive chemotherapy prior to CRT. Radiation was administered concurrently at 40 to 55 Gy according to the purpose of treatment. Sixteen patients received low dose CDDP and S-1. Of 8 patients who had measurable disease, one obtained CR and 3 obtained PR by the CRT. Fifteen percent of the distinct adverse effects of CRT were grade 3 leucopenia and 30% of them were grade 3 nausea. The 2-year-survival of patients who received CRT with curative intent was 91%, significantly higher than the percentage of those with palliative intent. Four patients who received R0 surgery following CRT are postoperatively healthy without symptoms of relapse. In conclusion, even though, 75% of the patients were already given chemotherapy prior to CRT, good outcomes were achieved unexpectedly. The combination of CRT and surgery may be a useful tool for chemo-resistant, locally advanced gastric cancer.

Original languageEnglish
Pages (from-to)727-731
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume40
Issue number6
Publication statusPublished - 06-2013

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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  • Cite this

    Ishigami, S., Arigami, T., Uenosono, Y., Okumura, H., Uchikado, Y., Owaki, T., Kijima, Y., Nakajo, A., Maemura, K., Ueno, S., Hokita, S., Hiraki, Y., Nakajo, M., & Natsugoe, S. (2013). Outcomes of advanced gastric cancer patients treated with chemoradiation therapy. Japanese Journal of Cancer and Chemotherapy, 40(6), 727-731.