Outcomes of hemodiafiltration based on Japanese dialysis patient registry

Shigeru Nakai, Kunitoshi Iseki, Kaoru Tabei, Kazuo Kubo, Ikuto Masakane, Kiyohide Fushimi, Kenjiro Kikuchi, Toru Shinzato, Tsutomu Sanaka, Takashi Akiba

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)


Effectiveness of various therapeutic modalities was analyzed among 1, 196 patients entered in the registry of the Japanese Society for Dialysis Therapy who were on hemopurification therapy as of the end of 1998 and developed dialysis-related amyloidosis during 1999. In the investigation, the effectiveness of various hemopurification modalities on the dialysis-related amyloidosis was ranked as exacerbation, unchanged, or alleviation, so as to analyze the possible relationship between the hemopurification modality and its effectiveness. The analysis was performed using a logistic regression approach, and the results were shown as "the risk of a worse therapeutic ranking" among the hemopurification modalities. The smaller "the risk of a worse therapeutic effect" was, the more effective the treatment modality. When the risk of a worse therapeutic effect for the hemodialysis patients treated by a regular membrane was put at 1.0, the risk for hemodialysis patients using high-flux membrane was 0.489, the off-line hemodiafiltration risk was 0.117, the on-line hemodiafiltration risk was 0.013, and the risk of push/pull hemodiafiltration was 0.017. For hemodialysis with a β2-microglobulin adsorption column, a low risk of 0.054 was found. The results indicated that hemodiafiltration therapy and simultaneous hemodialysis with β2-microglobulin adsorption therapy were more effective treatment for dialysis-related amyloidosis.

Original languageEnglish
Pages (from-to)S212-S216
JournalAmerican Journal of Kidney Diseases
Issue number4
Publication statusPublished - 10-2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Nephrology


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