Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae

Dóra Szabó, Fernanda Silveira, Andrea M. Hujer, Robert A. Bonomo, Kristine M. Hujer, Jane W. Marsh, Christopher R. Bethel, Yohei Doi, Kathleen Deeley, David L. Paterson

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Abstract

We investigated ertapenem-susceptible and -resistant extended-spectrum β-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant strain, suggesting a potential role of efflux pumps in ertapenem resistance.

Original languageEnglish
Pages (from-to)2833-2835
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume50
Issue number8
DOIs
Publication statusPublished - 01-08-2006

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Szabó, D., Silveira, F., Hujer, A. M., Bonomo, R. A., Hujer, K. M., Marsh, J. W., Bethel, C. R., Doi, Y., Deeley, K., & Paterson, D. L. (2006). Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae. Antimicrobial agents and chemotherapy, 50(8), 2833-2835. https://doi.org/10.1128/AAC.01591-05