Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae

Dóra Szabó; Fernanda Silveira; Andrea M. Hujer; Robert A. Bonomo; Kristine M. Hujer; Jane W. Marsh; Christopher R. Bethel; Yohei Doi; Kathleen Deeley; David L. Paterson

doi:10.1128/AAC.01591-05

Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae

Dóra Szabó
, Fernanda Silveira
, Andrea M. Hujer
, Robert A. Bonomo
, Kristine M. Hujer
, Jane W. Marsh
, Christopher R. Bethel
, Yohei Doi
, Kathleen Deeley
, David L. Paterson

Research output: Contribution to journal › Article › peer-review

85 Citations (Scopus)

Abstract

We investigated ertapenem-susceptible and -resistant extended-spectrum β-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant strain, suggesting a potential role of efflux pumps in ertapenem resistance.

Original language	English
Pages (from-to)	2833-2835
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	50
Issue number	8
DOIs	https://doi.org/10.1128/AAC.01591-05
Publication status	Published - 08-2006
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.01591-05

Cite this

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title = "Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae",

abstract = "We investigated ertapenem-susceptible and -resistant extended-spectrum β-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant strain, suggesting a potential role of efflux pumps in ertapenem resistance.",

author = "D{\'o}ra Szab{\'o} and Fernanda Silveira and Hujer, \{Andrea M.\} and Bonomo, \{Robert A.\} and Hujer, \{Kristine M.\} and Marsh, \{Jane W.\} and Bethel, \{Christopher R.\} and Yohei Doi and Kathleen Deeley and Paterson, \{David L.\}",

year = "2006",

month = aug,

doi = "10.1128/AAC.01591-05",

language = "English",

volume = "50",

pages = "2833--2835",

journal = "Antimicrobial agents and chemotherapy",

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T1 - Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae

AU - Szabó, Dóra

AU - Silveira, Fernanda

AU - Hujer, Andrea M.

AU - Bonomo, Robert A.

AU - Hujer, Kristine M.

AU - Marsh, Jane W.

AU - Bethel, Christopher R.

AU - Doi, Yohei

AU - Deeley, Kathleen

AU - Paterson, David L.

PY - 2006/8

Y1 - 2006/8

N2 - We investigated ertapenem-susceptible and -resistant extended-spectrum β-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant strain, suggesting a potential role of efflux pumps in ertapenem resistance.

AB - We investigated ertapenem-susceptible and -resistant extended-spectrum β-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant strain, suggesting a potential role of efflux pumps in ertapenem resistance.

UR - https://www.scopus.com/pages/publications/33746928431

UR - https://www.scopus.com/pages/publications/33746928431#tab=citedBy

U2 - 10.1128/AAC.01591-05

DO - 10.1128/AAC.01591-05

M3 - Article

C2 - 16870780

AN - SCOPUS:33746928431

SN - 0066-4804

VL - 50

SP - 2833

EP - 2835

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 8

ER -

Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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