TY - JOUR
T1 - Ovarian cancer-associated mesothelial cells
T2 - Transdifferentiation to minions of cancer and orchestrate developing peritoneal dissemination
AU - Mogi, Kazumasa
AU - Yoshihara, Masato
AU - Iyoshi, Shohei
AU - Kitami, Kazuhisa
AU - Uno, Kaname
AU - Tano, Sho
AU - Koya, Yoshihiro
AU - Sugiyama, Mai
AU - Yamakita, Yoshihiko
AU - Nawa, Akihiro
AU - Tomita, Hiroyuki
AU - Kajiyama, Hiroaki
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/3/2
Y1 - 2021/3/2
N2 - Ovarian cancer has one of the poorest prognoses among carcinomas. Advanced ovarian cancer often develops ascites and peritoneal dissemination, which is one of the poor prognostic factors. From the perspective of the “seed and soil” hypothesis, the intra-abdominal environment is like the soil for the growth of ovarian cancer (OvCa) and mesothelial cells (MCs) line the top layer of this soil. In recent years, various functions of MCs have been reported, including supporting cancer in the OvCa microenvironment. We refer to OvCa-associated MCs (OCAMs) as MCs that are stimulated by OvCa and contribute to its progression. OCAMs promote OvCa cell adhesion to the peritoneum, invasion, and metastasis. Elucidation of these functions may lead to the identification of novel therapeutic targets that can delay OvCa progression, which is difficult to cure.
AB - Ovarian cancer has one of the poorest prognoses among carcinomas. Advanced ovarian cancer often develops ascites and peritoneal dissemination, which is one of the poor prognostic factors. From the perspective of the “seed and soil” hypothesis, the intra-abdominal environment is like the soil for the growth of ovarian cancer (OvCa) and mesothelial cells (MCs) line the top layer of this soil. In recent years, various functions of MCs have been reported, including supporting cancer in the OvCa microenvironment. We refer to OvCa-associated MCs (OCAMs) as MCs that are stimulated by OvCa and contribute to its progression. OCAMs promote OvCa cell adhesion to the peritoneum, invasion, and metastasis. Elucidation of these functions may lead to the identification of novel therapeutic targets that can delay OvCa progression, which is difficult to cure.
KW - Epithelial mesenchymal transition
KW - Mesothelial cells
KW - Ovarian cancer
KW - Peritoneal dissemination
KW - Tumor microenvironment
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U2 - 10.3390/cancers13061352
DO - 10.3390/cancers13061352
M3 - Review article
AN - SCOPUS:85102565976
SN - 2072-6694
VL - 13
SP - 1
EP - 13
JO - Cancers
JF - Cancers
IS - 6
M1 - 1352
ER -