Ovarian cancer-associated mesothelial cells: Transdifferentiation to minions of cancer and orchestrate developing peritoneal dissemination

Kazumasa Mogi, Masato Yoshihara, Shohei Iyoshi, Kazuhisa Kitami, Kaname Uno, Sho Tano, Yoshihiro Koya, Mai Sugiyama, Yoshihiko Yamakita, Akihiro Nawa, Hiroyuki Tomita, Hiroaki Kajiyama

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)

Abstract

Ovarian cancer has one of the poorest prognoses among carcinomas. Advanced ovarian cancer often develops ascites and peritoneal dissemination, which is one of the poor prognostic factors. From the perspective of the “seed and soil” hypothesis, the intra-abdominal environment is like the soil for the growth of ovarian cancer (OvCa) and mesothelial cells (MCs) line the top layer of this soil. In recent years, various functions of MCs have been reported, including supporting cancer in the OvCa microenvironment. We refer to OvCa-associated MCs (OCAMs) as MCs that are stimulated by OvCa and contribute to its progression. OCAMs promote OvCa cell adhesion to the peritoneum, invasion, and metastasis. Elucidation of these functions may lead to the identification of novel therapeutic targets that can delay OvCa progression, which is difficult to cure.

Original languageEnglish
Article number1352
Pages (from-to)1-13
Number of pages13
JournalCancers
Volume13
Issue number6
DOIs
Publication statusPublished - 02-03-2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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