Ovarian metastases from renal cell carcinoma: A report of two cases

Renal cell carcinoma is a malignant tumor that is prone to distant metastasis, primarily developing in the lungs, bones, lymph nodes, liver, and brain. Conversely, ovarian metastasis is rare, and its clinical characteristics and optimal treatment strategies remain unestablished. We report two cases with renal cell carcinoma and concomitant ovarian metastasis. Case 1 was of a 52-year-old woman with a metastatic tumor in the left ovary detected 9 years after radical nephrectomy for left-sided clear cell renal cell carcinoma. Case 2 was of a 56-year-old woman with a metastatic tumor in the right ovary detected 15 years after radical nephrectomy for right-sided clear cell renal cell carcinoma. In both cases, preoperative imaging revealed a pelvic tumor with a strong contrast effect. Surgery was performed for diagnosis and treatment of suspected ovarian metastasis from the renal cell carcinoma. Rapid intraoperative diagnosis was performed to determine the surgical approach, and the diagnosis of ovarian metastasis from renal cell carcinoma was made. Subsequently, bilateral adnexectomy was performed, and following pathological examination led to the definite diagnosis of ovarian metastasis from clear cell renal cell carcinoma. Long after radical nephrectomy, ovarian metastasis from the renal cell carcinoma can occur. Therefore, continuous follow-up is important. Complete resection of ovarian metastases from renal cell carcinoma may contribute to improved prognosis; however, more case studies are needed to establish standard treatment.